Brian Feldman, MD, PhD
C.N.H. Long Professor of Pediatrics (Endocrinology)Cards
About
Titles
C.N.H. Long Professor of Pediatrics (Endocrinology)
Section Chief, Pediatric Endocrinology & Diabetes
Biography
Dr. Brian J. Feldman received his combined MD and PhD from Stanford University. He completed a residency in Pediatrics at Children’s Hospital Boston/ Harvard University followed by subspecialty training in Pediatric Endocrinology at the University of California, San Francisco (UCSF). Dr. Feldman then launched his independent research laboratory at Stanford University. He moved to UCSF in 2018 to become the inaugural Walter L. Miller Endowed Chair and Distinguished Professorship in Pediatric Endocrinology. Dr. Feldman has established a widely recognized international reputation for high-impact and cutting-edge research that is particularly relevant for human health. His current work broadly concerns the role of steroid hormones in determining cell fate, initially focusing on glucocorticoid-induced circadian alterations in carbohydrate metabolism, and more recently on the genesis of brown fat. His work has direct bearing on obesity, Type 2 diabetes and the determination of cell fate, and identified novel druggable targets. The impact of these discoveries has been repeatedly recognized with prestigious awards throughout his career. These include being awarded the coveted Clinical Scholars Award from the Pediatric Endocrine Society. He received the celebrated Young Investigator Award from the Society for Pediatric Research. He also received the Early Investigator Award from the Endocrine Society. He was awarded the NIH Director’s New Innovator Award. For his contributions as a physician-scientist, he was elected to membership into The American Association for Clinical Investigation (ASCI). Dr. Feldman is also dedicated to foster the career development of physician-scientists. He continuously volunteers his time to this mission.
Appointments
Pediatric Endocrinology & Diabetes
Section ChiefDualPediatric Endocrinology & Diabetes
ProfessorPrimary
Other Departments & Organizations
Education & Training
- Pediatric Endocrinology Fellowship
- University of California, San Francisco (UCSF)
- Resident
- Harvard University/ Boston Children's Hospital
- MD
- Stanford University
- PhD
- Stanford University
Board Certifications
Pediatric Endocrinology
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 2007
Research
Publications
2025
Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue
Li L, Feldman B. Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue. Stem Cell Reports 2025, 20: 102509. PMID: 40409261, PMCID: PMC12181967, DOI: 10.1016/j.stemcr.2025.102509.Peer-Reviewed Original ResearchConceptsInguinal white adipose tissueBrown adipose tissueSupraclavicular brown adipose tissuePreclinical modelsAdipose tissueActivation of beige adipocytesBeige adipose tissueAdipose tissue developmentWhite adipose tissueRobust preclinical modelsBeige fatDevelopmental originsMolecular markersSuccess of therapyTissue developmentThermogenic activityAdipose tissue depotsLineage tracingCell originLineagesAdipose depotsTherapeutic benefitMetabolic disordersTissue depotsMice
2024
White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models
Li L, Feldman B. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models. Journal Of Clinical Investigation 2024, 134: e172360. PMID: 38949025, PMCID: PMC11213504, DOI: 10.1172/jci172360.Peer-Reviewed Original ResearchConceptsWhite adipose tissueSubcutaneous white adipose tissueBrown adipose tissueDeletion of KLF15Transcription factor KLF15Visceral white adipose tissueHuman adipose cellsWhite adipocytesAdipose tissueMolecular mechanismsKLF15Adipose cellsDepot-specificAdipocytesNormal physiologySubcutaneous fat depotsCell-specific propertiesAdipose tissue depotsHealthy adipose tissueDirectional regulationMetabolic diseasesDevelopment of therapiesPathwayCellsMouse modelRepurposing mebendazole against triple-negative breast cancer CNS metastasis
Rodrigues A, Chernikova S, Wang Y, Trinh T, Solow-Cordero D, Alexandrova L, Casey K, Alli E, Aggarwal A, Quill T, Koegel A, Feldman B, Ford J, Hayden-Gephart M. Repurposing mebendazole against triple-negative breast cancer CNS metastasis. Journal Of Neuro-Oncology 2024, 168: 125-138. PMID: 38563850, PMCID: PMC11093727, DOI: 10.1007/s11060-024-04654-x.Peer-Reviewed Original ResearchConceptsMDA-MB-231-BRCentral nervous systemLeptomeningeal diseaseBreast cancer subtypesCNS metastasesLeptomeningeal spreadCancer subtypesCentral nervous system metastasesInternal carotid artery injectionPurposeTriple-negative breast cancerTNBC cell line MDA-MB-231Brain metastasis modelEffective oral agentBALB/c athymic nude miceLimited treatment optionsCell line MDA-MB-231In vitro migration assayAthymic nude miceCentral nervous system pathologyMigration assaySpread of cancerMDA-MB-231Oral agentsTreatment optionsEffect of mebendazole
2023
Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo
Babel N, Feldman B. Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo. Steroids 2023, 201: 109336. PMID: 37944652, PMCID: PMC11005958, DOI: 10.1016/j.steroids.2023.109336.Peer-Reviewed Original ResearchQuantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown
Li L, Gunewardena A, Nyima T, Feldman B. Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown. STAR Protocols 2023, 4: 102607. PMID: 37742183, PMCID: PMC10751552, DOI: 10.1016/j.xpro.2023.102607.Peer-Reviewed Original ResearchIdentification of an adipose tissue-resident pro-preadipocyte population
Chen M, Kim S, Li L, Chattopadhyay S, Rando T, Feldman B. Identification of an adipose tissue-resident pro-preadipocyte population. Cell Reports 2023, 42: 112440. PMID: 37119138, PMCID: PMC10370484, DOI: 10.1016/j.celrep.2023.112440.Peer-Reviewed Original ResearchConceptsDeconvolution of cell typesSingle-cell RNA sequencingCell typesScRNA-seqRNA sequencingRegulate adipogenesisPopulation of cellsHeterogeneous population of cellsExpression profilesStromal vascular fractionAdipocyte lineagePreadipocyte populationPathwayProgenitor cellsTherapeutic opportunitiesCellsPhysiological mechanismsAdipose tissueHeterogeneous populationLineagesStem cellsFunctional propertiesPreadipocytesProgenitorsSequence
2021
MYH9 facilitates autoregulation of adipose tissue depot development
Cheung S, Sayeed M, Nakuluri K, Li L, Feldman B. MYH9 facilitates autoregulation of adipose tissue depot development. JCI Insight 2021, 6: e136233. PMID: 33986190, PMCID: PMC8262332, DOI: 10.1172/jci.insight.136233.Peer-Reviewed Original ResearchConceptsMature adipocytesProgenitor cellsModulate systemic metabolismAdipogenesis in vivoPostnatal lifeExtracellular inputsWhite adipose tissueHormone signalingAdipose tissueEarly postnatal lifeDifferentiation of progenitor cellsTissue formation in vivoFormation in vivoEnergy storageSystemic metabolismAdipose depotsAdipocytesMYH9CellsDepot formationTissueAdipose14 The Adrenal Cortex and Its Disorders
Miller W, Flück C, Breault D, Feldman B. 14 The Adrenal Cortex and Its Disorders. 2021, 425-490. DOI: 10.1016/b978-0-323-62520-3.00014-2.Peer-Reviewed Original ResearchAdrenocorticotropic hormoneSteroid measurementsDeficiency statesLong-term glucocorticoid treatmentGenetic disordersEvaluation of adrenal functionHormone productionAssociated with genetic disordersSteroid hormone productionSteroidogenic cellsPrincipal mineralocorticoidAdrenal tumorsAdrenal insufficiencyCushing's syndromeAdrenal disordersSteroid excessConn's syndromeTumor originGlucocorticoid treatmentMineralocorticoid excessAdrenal functionGlucocorticoid excessAddison's diseaseGenetic causeAdrenal cortex
2020
SAT-585 Autoregulation of Adipose Tissue Development
Feldman B, Sayeed M, Nakuluri K. SAT-585 Autoregulation of Adipose Tissue Development. Journal Of The Endocrine Society 2020, 4: sat-585. PMCID: PMC7209260, DOI: 10.1210/jendso/bvaa046.389.Peer-Reviewed Original ResearchWhite adipose tissueABSTRACT White adipose tissueMature adipocytesProgenitor cellsModulate systemic metabolismPostnatal lifeAdipose depotsAdipogenesis in vivoTissue formation in vivoExtracellular inputsAdipose tissueHormone signalingEnergy storageEarly postnatal lifeDifferentiation of progenitor cellsUnrecognized signalFormation in vivoSystemic metabolismAdipocytesHomeostatic levelsAdipogenesisCellsAdiposeDepot formationA Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography
Huang Y, Zhao N, Wang Y, Truillet C, Wei J, Blecha J, VanBrocklin H, Seo Y, Sayeed M, Feldman B, Aggarwal R, Behr S, Shao H, Wilson D, Villanueva-Meyer J, Gestwicki J, Evans M. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS Chemical Biology 2020, 15: 1381-1391. PMID: 32255605, PMCID: PMC8031368, DOI: 10.1021/acschembio.9b01043.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBind GRGlucocorticoid receptorEmission tomographyGR agonist dexamethasoneGlucocorticoid receptor expressionGR modulatorsAdipose tissue of miceGR expression levelsTissues of miceReceptor expressionAgonist dexamethasoneArylboronic acid pinacol estersGR expressionKnockout miceGR signalingNuclear hormone receptorsPharmacological modulationHormone receptorsSevere diseaseAdipose tissueTissue levelsDecay corrected radiochemical yieldMiceHistorical screening
Clinical Care
Board Certifications
Pediatric Endocrinology
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 2007
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