Liang Li
Associate Research ScientistDownloadHi-Res Photo
About
Copy Link
Titles
Associate Research Scientist
Departments & Organizations
Education & Training
- Postdoctoral fellow
- University of California, San Francisco (2024)
- PhD
- Peking Union Medical College, Biochemistry& Molecular Biology (2018)
Research
Copy Link
Overview
Adipose tissue has important implications for metabolism and general health. Enhancing energy utilization by increasing the number and activity of beige adipocytes, an inducible form of thermogenic fat cells, can be of therapeutic benefit for a broad range of metabolic disorders.
My research focuses on understanding how thermogenic fat cells are created in vivo and what determines their metabolic phenotypes under physiological and pathological conditions. I'm also interested in exploring the application and utility of adipose tissue preclinical model in anti-obesity drug discovery.
In the long term, the goal is to use our understanding of the thermogenic fat cells development to guide strategies for expanding metabolically beneficial adipocyte phenotypes for the treatment of obesity and metabolic disease.
ORCID
0009-0002-1543-1818
Research at a Glance
Yale Co-Authors
Frequent collaborators of Liang Li's published research.
Publications Timeline
A big-picture view of Liang Li's research output by year.
Brian Feldman, MD, PhD
10Publications
119Citations
Publications
2025
Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue
Li L, Feldman B. Characterization and lineage tracing of a mouse adipose depot reveal properties conserved with human supraclavicular brown adipose tissue. Stem Cell Reports 2025, 20: 102509. PMID: 40409261, PMCID: PMC12181967, DOI: 10.1016/j.stemcr.2025.102509.Peer-Reviewed Original ResearchCitationsAltmetric
2024
White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models
Li L, Feldman B. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models. Journal Of Clinical Investigation 2024, 134: e172360. PMID: 38949025, PMCID: PMC11213504, DOI: 10.1172/jci172360.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown
Li L, Gunewardena A, Nyima T, Feldman B. Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown. STAR Protocols 2023, 4: 102607. PMID: 37742183, PMCID: PMC10751552, DOI: 10.1016/j.xpro.2023.102607.Peer-Reviewed Original ResearchAltmetricIdentification of an adipose tissue-resident pro-preadipocyte population
Chen M, Kim S, Li L, Chattopadhyay S, Rando T, Feldman B. Identification of an adipose tissue-resident pro-preadipocyte population. Cell Reports 2023, 42: 112440. PMID: 37119138, PMCID: PMC10370484, DOI: 10.1016/j.celrep.2023.112440.Peer-Reviewed Original ResearchCitationsAltmetric
2022
The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30
Ma M, Zhou J, Ma Z, Chen H, Li L, Hou L, Yin B, Qiang B, Shu P, Peng X. The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30. Cells 2022, 11: 1450. PMID: 35563756, PMCID: PMC9103646, DOI: 10.3390/cells11091450.Peer-Reviewed Original ResearchCitations
2021
MYH9 facilitates autoregulation of adipose tissue depot development
Cheung S, Sayeed M, Nakuluri K, Li L, Feldman B. MYH9 facilitates autoregulation of adipose tissue depot development. JCI Insight 2021, 6: e136233. PMID: 33986190, PMCID: PMC8262332, DOI: 10.1172/jci.insight.136233.Peer-Reviewed Original ResearchCitationsAltmetric
2019
The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling
Li L, Ruan X, Wen C, Chen P, Liu W, Zhu L, Xiang P, Zhang X, Wei Q, Hou L, Yin B, Yuan J, Qiang B, Shu P, Peng X. The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Reports 2019, 28: 698-711.e5. PMID: 31315048, DOI: 10.1016/j.celrep.2019.06.055.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsbeta CateninCell ProliferationChromatin Immunoprecipitation SequencingDNA-Binding ProteinsGene Expression Regulation, DevelopmentalGene OntologyHistonesMethylationMiceNeocortexNeural Stem CellsNeurogenesisNeuronsRNA-SeqS Phase Cell Cycle CheckpointsTelencephalonTranscription FactorsTranscriptional ActivationUp-RegulationWnt Signaling PathwayPTB-AS, a Novel Natural Antisense Transcript, Promotes Glioma Progression by Improving PTBP1 mRNA Stability with SND1
Zhu L, Wei Q, Qi Y, Ruan X, Wu F, Li L, Zhou J, Liu W, Jiang T, Zhang J, Yin B, Yuan J, Qiang B, Han W, Peng X. PTB-AS, a Novel Natural Antisense Transcript, Promotes Glioma Progression by Improving PTBP1 mRNA Stability with SND1. Molecular Therapy 2019, 27: 1621-1637. PMID: 31253583, PMCID: PMC6731175, DOI: 10.1016/j.ymthe.2019.05.023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords3' Untranslated RegionsCell Line, TumorCell MovementCell ProliferationEndonucleasesGene Expression Regulation, NeoplasticGliomaHeterogeneous-Nuclear RibonucleoproteinsHumansMicroRNAsPolypyrimidine Tract-Binding ProteinRNA InterferenceRNA StabilityRNA-Binding ProteinsRNA, AntisenseRNA, Long NoncodingRNA, Messenger
2018
Generating a reporter mouse line marking medium spiny neurons in the developing striatum driven by Arpp21 cis-regulatory elements
Chen P, Ruan X, Chen Y, Chu S, Mo K, Wu C, Liu W, Yin B, Zhou J, Li L, Hou L, Yuan J, Qiang B, Chen J, Shu P, Peng X. Generating a reporter mouse line marking medium spiny neurons in the developing striatum driven by Arpp21 cis-regulatory elements. Journal Of Genetics And Genomics 2018, 45: 673-676. PMID: 30595471, DOI: 10.1016/j.jgg.2018.09.007.Commentaries, Editorials and LettersCitations
2017
Mutation of the cellular adhesion molecule NECL2 is associated with neuromyelitis optica spectrum disorder
Xu Y, Li L, Ren H, Yin B, Yuan J, Peng X, Qiang B, Cui L. Mutation of the cellular adhesion molecule NECL2 is associated with neuromyelitis optica spectrum disorder. Journal Of The Neurological Sciences 2017, 388: 133-138. PMID: 29627007, DOI: 10.1016/j.jns.2017.10.023.Peer-Reviewed Original ResearchCitationsAltmetric
Get In Touch
Copy Link