Andrew Solomon, PhD
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Research
Publications
2025
Lipoic Acid for Treatment of Progressive Multiple Sclerosis
Spain R, Paz Soldán M, Freedman M, Repovic P, Solomon A, Rinker J, Wallin M, Haselkorn J, Stuve O, Gross R, Waslo C, Hildebrand A, Morris C, Mitchell J, Turner A, Schwartz D, Metz J, Rooney W. Lipoic Acid for Treatment of Progressive Multiple Sclerosis. Neurology 2025, 106: e214454. PMID: 41397213, PMCID: PMC12714125, DOI: 10.1212/wnl.0000000000214454.Peer-Reviewed Original ResearchConceptsLA participantsDisease-modifying therapiesSecondary progressive MSExpanded Disability Status ScaleProgressive MSProgressive multiple sclerosisWalking speedAdverse eventsBrain atrophyGray matter volumeMultiple sclerosisLA groupT2-weighted lesion volumeWhole-brain volumePlacebo-controlled clinical trialTreatment of progressive multiple sclerosisDeep gray matter volumesTimed 25-Foot WalkIntention-to-treat analysisPatient-reported disabilityVeterans Affairs Medical CenterWhole-brain atrophyClass II evidenceMedian EDSS scoreMatter volumeThe revised 2024 McDonald criteria can solve the misdiagnosis problem in multiple sclerosis: YES.
Ramanathan S, Solomon A. The revised 2024 McDonald criteria can solve the misdiagnosis problem in multiple sclerosis: YES. Multiple Sclerosis Journal 2025, 13524585251396284. PMID: 41388897, DOI: 10.1177/13524585251396284.Peer-Reviewed Original ResearchDiagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria
Montalban X, Lebrun-Frénay C, Oh J, Arrambide G, Moccia M, Pia Amato M, Amezcua L, Banwell B, Bar-Or A, Barkhof F, Butzkueven H, Ciccarelli O, Chataway J, Cohen J, Comi G, Correale J, Deisenhammer F, Filippi M, Fiol J, Freedman M, Fujihara K, Granziera C, Green A, Hartung H, Hellwig K, Kappos L, Kimbrough D, Killestein J, Lublin F, Marignier R, Ann Marrie R, Miller A, Otero-Romero S, Ontaneda D, Ramanathan S, Reich D, Rocca M, Rovira À, Saidha S, Salter A, Sastre-Garriga J, Saylor D, Solomon A, Sormani M, Stankoff B, Tintore M, Tremlett H, Van der Walt A, Viswanathan S, Wiendl H, Wildemann B, Yamout B, Zaratin P, Calabresi P, Coetzee T, Thompson A. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. The Lancet Neurology 2025, 24: 850-865. PMID: 40975101, DOI: 10.1016/s1474-4422(25)00270-4.Peer-Reviewed Original ResearchConceptsDiagnosis of multiple sclerosisMultiple sclerosisMcDonald criteriaFree light chain concentrationsRadiologically isolated syndromeMcDonald diagnostic criteriaCentral vein signParamagnetic rim lesionsProgression of disabilityMultiple sclerosis diagnosisOptic nerveNeurological symptomsProgressive courseRim lesionsAnatomical locationDiagnostic criteriaDiagnosisRevision criteriaSclerosisOlder individualsSupportive evidenceThe 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis
Solomon A, Brodersen J. The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis. Nature Reviews Neurology 2025, 21: 659-660. PMID: 40962996, DOI: 10.1038/s41582-025-01140-4.Peer-Reviewed Original ResearchQuantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine
Levit E, Horwath E, Schwartz D, Silbert L, Shinohara R, Solomon A. Quantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine. Annals Of Clinical And Translational Neurology 2025, 12: 2569-2574. PMID: 40954941, PMCID: PMC12698934, DOI: 10.1002/acn3.70193.Peer-Reviewed Original ResearchCerebrovascular diseaseMS diagnosisAssociated with MS diagnosisMultiple sclerosisPerivascular spacesPerivascular spaces numberMRI white matter abnormalitiesT2 hyperintense lesionsDiagnosis of MSLongitudinal cohortWhite matter abnormalitiesLogistic regressionPrimary outcomeMisdiagnosis of MSVascular comorbiditiesHyperintense lesionsFLAIR sequencesROC analysisT MRIT1-weightedBrain perivascular spacesMigraineParticipantsDiagnosisCohortA Novel Convolutional Neural Network for Automated Multiple Sclerosis Brain Lesion Segmentation
Dereskewicz E, La Rosa F, Dos Santos Silva J, Sizer E, Kohli A, Wynen M, Mullins W, Maggi P, Levy S, Onyemeh K, Ayci B, Solomon A, Assländer J, Al‐Louzi O, Reich D, Sumowski J, Beck E. A Novel Convolutional Neural Network for Automated Multiple Sclerosis Brain Lesion Segmentation. Journal Of Neuroimaging 2025, 35: e70085. PMID: 40937688, PMCID: PMC12426979, DOI: 10.1111/jon.70085.Peer-Reviewed Original ResearchFrequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic
Renner B, Verter E, Absinta M, Daboul L, Raza P, Martin M, Cao Q, O'Donnell C, Rodrigues P, Ramos M, Prchkovska V, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Ontaneda D, Sati P. Frequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic. Neurology 2025, 105: e213912. PMID: 40893055, PMCID: PMC12596004, DOI: 10.1212/wnl.0000000000213912.Peer-Reviewed Original ResearchConceptsParamagnetic rim lesionsDiagnosis of MSClinically established diagnosisRadiological suspicionMultiple sclerosisClinical presentationMcDonald criteriaDiagnostic performanceRim lesionsSymptom onsetDiagnostic valueImaging biomarkersDiagnostic implicationsActive multiple sclerosisMultiple Sclerosis ClinicChronic active multiple sclerosisAlternative diagnosesClinical symptomsAssociated with higher probabilityBrain MRIObservational studyDiagnostic thresholdMS centersGold standardDiagnosisRotational Power: A New Accelerometer-Derived Metric to Assess Functional Impairment in Multiple Sclerosis
Mascia G, Meyer B, Cherian J, Kairamkonda D, Fanning J, Rice P, Sosnoff J, Solomon A, McGinnis E, McGinnis R. Rotational Power: A New Accelerometer-Derived Metric to Assess Functional Impairment in Multiple Sclerosis. IEEE Transactions On Neural Systems And Rehabilitation Engineering 2025, 33: 3096-3104. PMID: 40742863, PMCID: PMC12406280, DOI: 10.1109/tnsre.2025.3594540.Peer-Reviewed Original ResearchConceptsSit-to-standStand-to-sitAcute fatigueActivities Specific Balance Confidence ScaleModified Fatigue Impact ScaleBalance Confidence ScaleChair stand testPeak mechanical powerFree-Living SettingsFatigue Impact ScaleRotational powerMotion capture systemMuscular strengthMultiple sclerosisConfidence ScaleImpact ScaleImpaired mobilityLower limbsFunctional performanceMechanical powerFunctional assessmentClinical measuresSignificant associationFunctional impairmentBody-massShared decision-making for multiple sclerosis using the MS-SUPPORT tool: a plain language summary
Col N, Solomon A, Alvarez E, Pbert L, Ionete C, Morales I, Chester J, Kutz C, Iwuchukwu C, Livingston T, Springmann V, Col H, Ngo L. Shared decision-making for multiple sclerosis using the MS-SUPPORT tool: a plain language summary. Neurodegenerative Disease Management 2025, 15: 97-106. PMID: 40329687, PMCID: PMC12118401, DOI: 10.1080/17582024.2025.2493028.Peer-Reviewed Original ResearchQuality of lifeMental healthDays of poor mental healthPoor mental healthMultiple sclerosisHealthcare professionalsHealthcare providersTreatment journeyPrescribed treatment planImprove communicationMS symptomsDisease-modifying therapiesTreatment planningHealthcareTreatment decisionsHealthDoctorsPlain Language SummaryCliniciansPeopleSummaryDecision-makingLanguage SummaryProvidersProfessionalsDiagnostic delay and misdiagnosis of symptoms reported by patients with multiple sclerosis participating in a research registry
Solomon A, Weinstein S, Shinohara R, Aoun S, Schmidt H, Solari A. Diagnostic delay and misdiagnosis of symptoms reported by patients with multiple sclerosis participating in a research registry. Multiple Sclerosis Journal - Experimental Translational And Clinical 2025, 11: 20552173251333390. PMID: 40292040, PMCID: PMC12033781, DOI: 10.1177/20552173251333390.Peer-Reviewed Original ResearchInitial symptom of MSDiagnostic delayMisdiagnosis of symptomsMultiple sclerosisSymptoms of MSAssociated with longer diagnostic delayLong diagnostic delayDiagnostic journey of patientsMS diagnostic criteriaJourney of patientsPatient RegistryDiagnostic criteriaPreventable causeMisdiagnosisDiagnostic journeyResearch RegistrySymptomsCohort dataPatientsCriteria revisionMedianRegistrySclerosisSurvey studyParticipants
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