Jonadab Dos Santos Silva, MD
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Biography
Jonadab dos Santos Silva is a physician and researcher with a background in neurology and neuroimaging. He graduated with a degree in medicine from the Fluminense Federal University in Brazil. He also attended UCLA during medical school. He was a postdoctoral research fellow at the Icahn School of Medicine, where he worked on the clinical and cognitive manifestations of multiple sclerosis using ultra-high-field MRI to study the mechanisms of cortical lesion formation and repair, as well as how these processes are related to brain remodeling and disease progression. He has worked with various modalities in clinical studies, such as structural and functional MRI, EEG source localization, and tractography. His primary interests are the interplay between brain lesions and their clinical and cognitive manifestations, and his work aims to translate cutting-edge research into clinical practice, enhancing diagnostic and therapeutic strategies for patients with neurological conditions.
Departments & Organizations
Education & Training
- Postdoctoral Research Fellow
- Icahn School of Medicine at Mount Sinai (2024)
- MD
- Universidade Federal Fluminense, Medicine (2022)
- MD
- University of California, Los Angeles, Medicine, Exchange Program (2016)
Research
Overview
Medical Research Interests
Cognition; Diffusion Tensor Imaging; Epilepsy; Functional Neuroimaging; Magnetic Resonance Imaging; Multiparametric Magnetic Resonance Imaging; Multiple Sclerosis; Neuroimaging; Neurology; Neuropsychology
ORCID
0000-0002-4216-333X
Research at a Glance
Publications Timeline
A big-picture view of Jonadab Dos Santos Silva's research output by year.
12Publications
Publications
Featured Publications
Contribution of new and chronic cortical lesions to disability accrual in multiple sclerosis.
Beck ES, Mullins WA, Dos Santos Silva J, Filippini S, Parvathaneni P, Maranzano J, Morrison M, Suto DJ, Donnay C, Dieckhaus H, Luciano NJ, Sharma K, Gaitán MI, Liu J, de Zwart JA, van Gelderen P, Cortese I, Narayanan S, Duyn JH, Nair G, Sati P, Reich DS. Contribution of new and chronic cortical lesions to disability accrual in multiple sclerosis. Brain Commun 2024, 6: fcae158. PMID: 38818331, DOI: 10.1093/braincomms/fcae158.Peer-Reviewed Original Research
2024
BrainAgeNeXt: Advancing Brain Age Modeling for Individuals with Multiple Sclerosis.
La Rosa F, Dos Santos Silva J, Dereskewicz E, Invernizzi A, Cahan N, Galasso J, Garcia N, Graney R, Levy S, Verma G, Balchandani P, Reich DS, Horton M, Greenspan H, Sumowski J, Cuadra MB, Beck ES. BrainAgeNeXt: Advancing Brain Age Modeling for Individuals with Multiple Sclerosis. MedRxiv 2024 PMID: 39148818, DOI: 10.1101/2024.08.10.24311686.Peer-Reviewed Original ResearchThe global patient-reported outcomes for multiple sclerosis initiative: bridging the gap between clinical research and care - updates at the 2023 plenary event.
Zaratin P, Samadzadeh S, Seferoğlu M, Ricigliano V, Dos Santos Silva J, Tunc A, Brichetto G, Coetzee T, Helme A, Khan U, McBurney R, Peryer G, Weiland H, Baneke P, Battaglia MA, Block V, Capezzuto L, Carment L, Cortesi PA, Cutter G, Leocani L, Hartung HP, Hillert J, Hobart J, Immonen K, Kamudoni P, Middleton R, Moghames P, Montalban X, Peeters L, Sormani MP, van Tonder S, White A, Comi G, Vermersch P. The global patient-reported outcomes for multiple sclerosis initiative: bridging the gap between clinical research and care - updates at the 2023 plenary event. Front Neurol 2024, 15: 1407257. PMID: 38974689, DOI: 10.3389/fneur.2024.1407257.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Cortical lesions uniquely predict motor disability accrual and form rarely in the absence of new white matter lesions in multiple sclerosis.
Beck ES, Mullins WA, Dos Santos Silva J, Filippini S, Parvathaneni P, Maranzano J, Morrison M, Suto DJ, Donnay C, Dieckhaus H, Luciano NJ, Sharma K, Gaitán MI, Liu J, de Zwart JA, van Gelderen P, Cortese I, Narayanan S, Duyn JH, Nair G, Sati P, Reich DS. Cortical lesions uniquely predict motor disability accrual and form rarely in the absence of new white matter lesions in multiple sclerosis. MedRxiv 2023 PMID: 37886541, DOI: 10.1101/2023.09.22.23295974.Peer-Reviewed Original ResearchPredictive factors for successful vagus nerve stimulation in patients with refractory epilepsy: real-life insights from a multicenter study.
Pires do Prado HJ, Pinto LF, Bezerra DF, de Paola L, Arruda F, de Oliveira AJ, Romão TT, Lessa VCC, Silva JDS, D'Andrea-Meira I. Predictive factors for successful vagus nerve stimulation in patients with refractory epilepsy: real-life insights from a multicenter study. Front Neurosci 2023, 17: 1210221. PMID: 37575303, DOI: 10.3389/fnins.2023.1210221.Peer-Reviewed Original ResearchUse of diffusion tensor imaging as a prognostic biomarker after decompression surgery for carpal tunnel syndrome.
Pinto da Silva FH, Dos Santos Silva J, Pereira de Barros LF, Souza RF, Landeiro JA, Rueda Lopes FC, da Silva MB, Fonseca GVS, Acioly MA. Use of diffusion tensor imaging as a prognostic biomarker after decompression surgery for carpal tunnel syndrome. Acta Radiol 2023, 64: 1109-1115. PMID: 35876308, DOI: 10.1177/02841851221113518.Peer-Reviewed Original ResearchVolumetric measurement of intracranial meningiomas: a comparison between linear, planimetric, and machine learning with multiparametric voxel-based morphometry methods.
Dos Santos Silva J, Schreiner CA, de Lima L, Brigido CEPL, Wilson CD, McVeigh L, Acchiardo J, Landeiro JA, Acioly MA, Cohen-Gadol A. Volumetric measurement of intracranial meningiomas: a comparison between linear, planimetric, and machine learning with multiparametric voxel-based morphometry methods. J Neurooncol 2023, 161: 235-243. PMID: 36058985, DOI: 10.1007/s11060-022-04127-z.Peer-Reviewed Original Research
2022
Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin-1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation.
Leis Ayres E, Dos Santos Silva J, Eberlin S, Facchini G, Vasconcellos C, Da Costa A. Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin-1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation. J Cosmet Dermatol 2022, 21: 1234-1242. PMID: 33960120, DOI: 10.1111/jocd.14202.Peer-Reviewed Original Research"Million dollar nerve" magnetic resonance neurography: first normal and pathological findings.
Dos Santos Silva J, de Barros LFP, de Freitas Souza R, Mendonça SM, Costa FM, Landeiro JA, Lopes FCR, Acioly MA. "Million dollar nerve" magnetic resonance neurography: first normal and pathological findings. Eur Radiol 2022, 32: 1154-1162. PMID: 34363135, DOI: 10.1007/s00330-021-08213-0.Peer-Reviewed Original Research
2018
Management of Early Intraoperative Superficial Temporal Artery to Middle Cerebral Artery Bypass Occlusion in a Moyamoya Patient: 3-Dimensional Operative Video.
da Cunha PR, Silva JDS, Benet A, Burkhardt JK, Tabani H, Lawton MT. Management of Early Intraoperative Superficial Temporal Artery to Middle Cerebral Artery Bypass Occlusion in a Moyamoya Patient: 3-Dimensional Operative Video. Oper Neurosurg (Hagerstown) 2018, 14: 459-460. PMID: 28973480, DOI: 10.1093/ons/opx156.Peer-Reviewed Case Reports and Technical Notes
Academic Achievements & Community Involvement
Activities
activity European Charcot Foundation
2022 - PresentProfessional OrganizationsFellowactivity Acta Neurologica Scandinavica
2025 - PresentJournal ServiceRevieweractivity Annals of Neuroscience
2025 - PresentJournal ServiceRevieweractivity Brain Imaging and Behavior
2025 - PresentJournal ServiceRevieweractivity Cerebrovascular Diseases
2025 - PresentJournal ServiceReviewer
Honors
honor Best poster, Neuroimaging at the BMEII Symposium
04/21/2023Other AwardBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount SinaiDetailsUnited Stateshonor ACTRIMS Educational Grant Award
02/12/2023National AwardAmericas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS)DetailsUnited Stateshonor NAIMS Educational Grant Award
02/11/2023National AwardNorth American Imaging in MS CooperativeDetailsUnited Stateshonor CTRIMS-ECF Young Investigator Award & Best oral presentation
06/18/2022International AwardEuropean Charcot FoundationDetailsBrazilhonor Best abstract presentation, 20th Brazilian and International Congress of Neuropsychology
10/09/2021National AwardBrazilian Society of NeuropsychologyDetailsBrazil
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