Abhishek Kumar, MBBS, FASN, MD, FAST
Associate Professor (Nephrology)Cards
About
Research
Publications
2025
Osimertinib activates a TGFβ2-dependent secretory program that drives lung adenocarcinoma progression
Ghosh M, Wu C, Kumar A, Nilsson M, Heymach J, Zhao W, Yu J, Liu X, Ding N, Wang S, Xiao G, Chen A, Grimley K, Russell W, Creighton C, Tan X, Kurie J. Osimertinib activates a TGFβ2-dependent secretory program that drives lung adenocarcinoma progression. Journal Of Clinical Investigation 2025, 136: e198418. PMID: 41364502, PMCID: PMC12867136, DOI: 10.1172/jci198418.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionLung adenocarcinomaDrug-naiveLung adenocarcinoma progressionProtumorigenic activityDN cellsParacrine mechanismsEmergence of drug toleranceEGFR-mutant lung adenocarcinomaMetastatic propertiesCocultured in vitroAnterograde traffickingTranscription factor ZEB1Trafficking of secretory vesiclesClinical outcomesDrug toleranceLUAD cell linesORS cellsAdenocarcinoma progressionParacrine signalingSecretory stateCongenic pairsSecretory programCell featuresTGF-b2StayRose: A photostable StayGold derivative redshifted by genetic code expansion
Scott W, Ivorra-Molla E, Akhuli D, Massam-Wu T, Lysyganicz P, Walsh R, Parent M, Cook J, Song L, Kumar A, Schneider F, Mishima M, Crow A, Balasubramanian M. StayRose: A photostable StayGold derivative redshifted by genetic code expansion. Journal Of Biological Chemistry 2025, 301: 110832. PMID: 41109344, PMCID: PMC12661434, DOI: 10.1016/j.jbc.2025.110832.Peer-Reviewed Original ResearchGenetic code expansionCode expansionFluorescent proteinHigh-resolution crystal structuresRed fluorescent proteinSuperfolder GFPEscherichia coliSequence engineeringAcquisition of high-quality imagesWavelength maximumZebrafish embryosExcitation wavelength maximumGFPProteinEmission wavelength maximumCrystal structureRedshiftAminoChromophoreSequenceZebrafishDerivativesMultiple targetsExcitationFoldingFocal adhesion-derived liquid-liquid phase separations regulate mRNA translation
Kumar A, Tanaka K, Schwartz M. Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation. ELife 2025, 13: rp96157. PMID: 40568958, PMCID: PMC12201949, DOI: 10.7554/elife.96157.Peer-Reviewed Original ResearchConceptsFocal adhesionsLiquid-liquid phase separationMRNA translationFocal adhesion protein p130CasIntegrin-mediated focal adhesionsFocal adhesion proteinsRNA-binding proteinsMessage translationAdhesion dynamicsP130CasAdhesion proteinsBinding proteinRegulatory mechanismsConcentrations of fibronectinCell behaviorPlate cellsSenescent cellsMRNAPhoto-inductionProteinCytoplasmCellsQuiescent stateMultiple componentsTranslationFocal adhesion-derived liquid-liquid phase separations regulate mRNA translation
Kumar A, Tanaka K, Schwartz M. Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation. ELife 2025, 13 DOI: 10.7554/elife.96157.2.Peer-Reviewed Original ResearchFocal adhesionsLiquid-liquid phase separationMRNA translationFocal adhesion protein p130CasIntegrin-mediated focal adhesionsFocal adhesion proteinsRNA-binding proteinsMessage translationAdhesion dynamicsP130CasAdhesion proteinsBinding proteinRegulatory mechanismsConcentrations of fibronectinCell behaviorPlate cellsSenescent cellsMRNAPhoto-inductionProteinCytoplasmCellsQuiescent stateMultiple componentsTranslationEarly Pre-Emptive Kidney Transplant Does Not Offer Any Mortality Benefits: A Study of Trends in Pre-Emptive Kidney Transplantation Over the Last Two Decades.
Kumar A, Bonnell L, Kuppachi S. Early Pre-Emptive Kidney Transplant Does Not Offer Any Mortality Benefits: A Study of Trends in Pre-Emptive Kidney Transplantation Over the Last Two Decades. Transplant Proc 2025 PMID: 40140312, DOI: 10.1016/j.transproceed.2025.02.032.Peer-Reviewed Original Research
2024
Pushing the Boundaries of Living Donation Through Kidney Paired Donation.
Kumar A, Nishio Lucar AG, Doshi MD. Pushing the Boundaries of Living Donation Through Kidney Paired Donation. Am J Kidney Dis 2024 PMID: 39706246, DOI: 10.1053/j.ajkd.2024.10.007.Peer-Reviewed Original ResearchCellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz U, Bai S, Nottoli T, Goult B, Humphrey J, Schwartz M. Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis. Science Advances 2024, 10: eadi6286. PMID: 39167642, PMCID: PMC11338229, DOI: 10.1126/sciadv.adi6286.Peer-Reviewed Original ResearchConceptsTissue mechanical homeostasisStiffness sensingExtracellular matrixTalin-1Mechanical homeostasisExtracellular matrix mechanicsIncreased cell spreadingCell spreadingTalinMutationsCellular sensingFibrillar collagenReduced axial stiffnessTissue mechanical propertiesMechanical propertiesAxial stiffnessCompliant substratesHomeostasisRupture pressureArp2/3ARPC5LStiffnessHomeostasis hypothesisResident cellsTissue stiffnessCalcium flow at ER-TGN contact sites facilitates secretory cargo export
Ramazanov B, Parchure A, Di Martino R, Kumar A, Chung M, Kim Y, Griesbeck O, Schwartz M, Luini A, von Blume J. Calcium flow at ER-TGN contact sites facilitates secretory cargo export. Molecular Biology Of The Cell 2024, 35: ar50. PMID: 38294859, PMCID: PMC11064664, DOI: 10.1091/mbc.e23-03-0099.Peer-Reviewed Original ResearchKidney after Liver Transplantation for All: Are You Kidneying Me?
Kumar A, Wadei HM. Kidney after Liver Transplantation for All: Are You Kidneying Me? Clin J Am Soc Nephrol 2024 PMID: 38265809, DOI: 10.2215/CJN.0000000000000409.Peer-Reviewed Original Research
2023
A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization
Yi Z, Xi C, Menon M, Cravedi P, Tedla F, Soto A, Sun Z, Liu K, Zhang J, Wei C, Chen M, Wang W, Veremis B, Garcia-Barros M, Kumar A, Haakinson D, Brody R, Azeloglu E, Gallon L, O'Connell P, Naesens M, Shapiro R, Colvin R, Ward S, Salem F, Zhang W. A large-scale retrospective study enabled deep-learning based pathological assessment of frozen procurement kidney biopsies to predict graft loss and guide organ utilization. Kidney International 2023, 105: 281-292. PMID: 37923131, PMCID: PMC10892475, DOI: 10.1016/j.kint.2023.09.031.Peer-Reviewed Original ResearchArterial intimal fibrosisGraft lossOrgan utilizationIntimal fibrosisSclerotic glomeruliLarge-scale retrospective studyGlomerular filtration rateDeceased donor kidneysPathologist scoresTransplant outcomesBiopsy findingsSurvival prediction modelWedge biopsyRisk stratificationRetrospective studyFiltration ratePathological assessmentDonor biopsiesNeedle biopsySimilar survivalHistological scoringUnnecessary organsDiscovery setKidneyLesion scores
Academic Achievements & Community Involvement
Clinical Care
Overview
Abhishek Kumar, MD, is a nephrologist who specializes in the care of patients with complex kidney transplant needs. He focuses on diagnosing and managing conditions related to kidney transplantation and aims to improve patient outcomes through comprehensive care strategies.
Dr. Kumar is dedicated to advancing the understanding of chronic kidney disease in patients who have received non-kidney organ transplants, with the goal of identifying those who might benefit from multi-organ transplants. As an associate professor at Yale School of Medicine, Dr. Kumar is involved in research that seeks to enhance predictive measures for chronic kidney disease in transplant patients.
He received his medical training from Jawaharlal Institute of Postgraduate Medical Education & Research in India. He completed his residency at the University of Illinois, followed by a fellowship in nephrology and transplant nephrology at the University of Iowa.
Clinical Specialties
Nephrology
Fact Sheets
Polycystic Kidney Disease (PKD)
Learn More on Yale MedicineKidney Transplant
Learn More on Yale MedicineAnesthesia for Organ Transplant
Learn More on Yale MedicineLiving Donor Organ Transplantation
Learn More on Yale Medicine
Yale Medicine News
News
News
Get In Touch
Contacts
Appointment Number
Mailing Address
Yale School of Medicine
330 Cedar Street
New Haven, CT 06510
United States
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.