Serena Susan Spudich, MD, MA
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Division Chief, Neurological Infections & Global Neurology
Co-Director, Yale Center for Brain & Mind Health
Affiliated Faculty, Yale Institute for Global Health
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Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Division Chief, Neurological Infections & Global Neurology
Co-Director, Yale Center for Brain & Mind Health
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Division Chief, Neurological Infections & Global Neurology
Co-Director, Yale Center for Brain & Mind Health
Affiliated Faculty, Yale Institute for Global Health
Contact Info
About
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Titles
Gilbert H. Glaser Professor of Neurology
Division Chief, Neurological Infections & Global Neurology; Co-Director, Yale Center for Brain & Mind Health; Affiliated Faculty, Yale Institute for Global Health
Appointments
Neurology
ProfessorPrimary
Other Departments & Organizations
- AIDS Care Program
- Brain Infections
- Center for Brain & Mind Health
- Center for Neuroepidemiology and Clinical Neurological Research
- COVID Mind Study at Yale
- Human and Translational Immunology Program
- MR Core
- Neurological Infections and Global Neurology
- Neurology
- Spudich Lab
- Yale Institute for Global Health
- Yale Medicine
- Yale New Haven Health System
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Fellow
- University of California at San Francisco (2004)
- Fellow
- Harvard Medical School (2003)
- Resident
- Harvard Medical School (2002)
- Resident
- University of Washington School of Medicine (1999)
- Intern
- University of Washington School of Medicine (1998)
- MD
- University of California at San Francisco (1997)
- MA
- Stanford University, Philosophy of Science (1992)
- BA
- Stanford University, Human Biology/Humanities (1991)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-6032-3950- View Lab Website
Spudich Lab
Research at a Glance
Publications Timeline
Research Interests
Biomarkers
Cerebrospinal Fluid
COVID-19
HIV
Neurology
Neuroinflammatory Diseases
Publications
2026
Central Nervous System HIV Persistence and Clinical Consequences During Suppressive ART
Holroyd K, Spudich S, Winston A, Nightingale S. Central Nervous System HIV Persistence and Clinical Consequences During Suppressive ART. Current HIV/AIDS Reports 2026, 23: 17. PMID: 42223553, DOI: 10.1007/s11904-026-00786-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVascular inflammation in neuropsychiatric long COVID
McAlpine L, Shorer E, Chiarella J, Nelson A, Veenhuis R, Azola A, Lee A, Pierce R, Farhadian S, Rubin L, Spudich S, Mind F, Groups I. Vascular inflammation in neuropsychiatric long COVID. Brain Behavior & Immunity - Health 2026, 54: 101247. PMID: 42099668, PMCID: PMC13147379, DOI: 10.1016/j.bbih.2026.101247.Peer-Reviewed Original ResearchAltmetricA novel measure of antiretroviral activity in cerebrospinal fluid and association with HIV persistence and cognitive function
AVEDISSIAN S, McCARTHY C, BOSCH R, SPUDICH S, GANDHI R, McMAHON D, ERON J, FLETCHER C. A novel measure of antiretroviral activity in cerebrospinal fluid and association with HIV persistence and cognitive function. AIDS 2026, 40: 763-770. PMID: 41587440, PMCID: PMC12866972, DOI: 10.1097/qad.0000000000004453.Peer-Reviewed Original Research
2025
A psychometric assessment of the Patient Health Questionnaire-9 for people living with acutely-treated HIV in Thailand
Hamby T, Pinyakorn S, Frndak S, Chomchey N, Kanaprach R, Chan P, Schluck G, Kroon E, Suttichom D, Poonpitak L, Sriplienchan S, Spudich S, Phanuphak N, Trautmann L, Paul R, Sacdalan C, Crowell T, Group T. A psychometric assessment of the Patient Health Questionnaire-9 for people living with acutely-treated HIV in Thailand. Psychiatry Research Communications 2025, 6: 100242. PMID: 42369326, PMCID: PMC13308563, DOI: 10.1016/j.psycom.2025.100242.Peer-Reviewed Original ResearchCitationsNeuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy
Chan P, Sacdalan C, Pinyakorn S, Kroon E, Colby D, Promsena P, Sriplienchan S, Phanuphak N, Vasan S, Valcour V, Paul R, Gisslén M, Zetterberg H, Trautmann L, Spudich S. Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy. Journal Of Infectious Diseases 2025, 233: e913-e922. PMID: 41254882, PMCID: PMC13127774, DOI: 10.1093/infdis/jiaf583.Peer-Reviewed Original ResearchAltmetricGreater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolzenius J. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 105: e214445. PMID: 41172230, PMCID: PMC12817266, DOI: 10.1212/wnl.0000000000214445.Commentaries, Editorials and LettersNeurosymptomatic Cerebrospinal Fluid Escape Is a Central Nervous System–Focused Form of Antiretroviral Therapy Treatment Failure
Kincer L, Dravid A, Zhou S, Vercesi R, Spudich S, Gisslén M, Price R, Cinque P, Joseph S. Neurosymptomatic Cerebrospinal Fluid Escape Is a Central Nervous System–Focused Form of Antiretroviral Therapy Treatment Failure. Open Forum Infectious Diseases 2025, 13: ofaf659. PMID: 41488692, PMCID: PMC12760783, DOI: 10.1093/ofid/ofaf659.Peer-Reviewed Original ResearchCitationsAltmetricAntiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2–LTR Circles Over 12 Weeks
Reed J, Hall L, McKhann A, Kwak G, Goecker E, Coombs R, Chen H, Roa J, Vecchio A, Daar E, Hunt P, Marra C, Campbell T, Ma Q, Swaminathan S, Macatangay B, Morse G, Miller T, Rusin D, Ha B, Alston-Smith B, Paul R, Letendre S, Spudich S, Greninger A. Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2–LTR Circles Over 12 Weeks. Open Forum Infectious Diseases 2025, 12: ofaf594. PMID: 41141451, PMCID: PMC12548372, DOI: 10.1093/ofid/ofaf594.Peer-Reviewed Original ResearchAltmetricCerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID
Orlinick B, Mehta S, McAlpine L, Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J, Das B, Patel V, Filippidis P, Corley M, Spudich S, Farhadian S. Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID. Journal Of Infectious Diseases 2025, 233: e109-e117. PMID: 40920586, PMCID: PMC12811860, DOI: 10.1093/infdis/jiaf468.Peer-Reviewed Original ResearchCitationsAltmetricOlfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort
Horwitz L, Becker J, Huang W, Akintonwa T, Hornig-Rohan M, Maranga G, Adams D, Albers M, Ayache M, Berry J, Brim H, Bryan T, Charney A, Clark R, Cortez M, D’Anza B, Davis H, Donohue S, Erdmann N, Flaherman V, Fong T, Frontera J, Goldberg M, Goldman J, Harkins M, Hodder S, Jacoby V, Jagannathan P, Jia X, Kelly J, Krishnan J, Kumar A, Laiyemo A, Levitan E, Martin J, McCaffrey K, McComsey G, Metz T, Murthy G, Nguyen H, Okumura M, Parry S, Parthasarathy S, Patterson T, Peluso M, Sorochinsky C, Walker T, Wiegand S, Wiley Z, Wisnivesky J, Ashktorab H, Foulkes A, Lee-Iannotti J, Han J, Marconi V, Ofotokun I, Patzer R, Walker T, Abraham R, Aguilar F, Ahmadi-Izad G, Ahmed D, Alvarez A, Anderson B, Asencios W, Beaty C, Bedi B, Berry J, Boone D, Bower M, Bremner J, Brent C, Brown-Smith K, Bull R, Capo G, Carl-Igwe K, Chitadze C, Chukwumerije N, Clyburn E, Collins S, Costello J, Couture G, Craft A, Cui X, del Rio C, Detelich J, Dixon C, Dow J, Doyle D, Elchommali J, Elsey I, Franks N, Gallini J, Gutter E, Harding J, Hernandez L, Holloway C, Ifejika C, Jasarevic R, Javia V, Jeter M, Joseph Y, Juarez M, Kirkpatrick C, Koumanelis A, Krishnan S, Leon J, Lew V, Maier C, Makkaoui N, Maroney M, Martin C, Mbogo L, McCaslin A, McIntyre J, Moanna A, Montoya M, Morales E, Moran C, Murray C, Nelson R, Nguyen T, Ojoawo B, Osinski E, Oviedo S, Paredes-Gaitan Y, Prude M, Ramakrishnan G, Rebolledo P, Roberts M, Robinson K, Rogers C, Rouphael N, Searles C, Segall M, Shah A, Silva R, Simpson C, Simpson-Derrell K, Sirajud-Deen T, Stroud J, Suthar M, Sylber C, Sylvera A, Teunis L, Thomas K, Titanji K, Toy C, Truong A, Vaccarino V, Varney K, Vyas K, Vyas K, Walkow M, Wesley T, Winston J, Winter T, Wongtrakool C, Cribbs S, Collins O, Fournier C, Francis A, Hang T, Ingram K, Lainez J, Rubinsztain L, Yeung H, Wiley Z, Ager A, Gray N, Grimes A, Gromer D, Hewitt L, Huerta C, Johnson B, Kelley C, Khalil L, Kleinhenz D, Koumanelis A, Kozoman R, Lee M, Lewis K, Litvack M, Maramba T, Mehta C, Panganiban B, Rahman K, Smith V, Stringer A, Tolbert M, Traenkner J, Unterberger K, Wang H, Wimberly E, Yang Q, Ryerson A, Hjortsberg R, Hudgins A, Martinez M, Neuman R, Thompson S, Agu C, Pemu P, Afani A, Ariri C, Dandy A, Harper K, Ibeawuchi C, Lawrence B, Morgan-Billingslea J, Ojemakinde E, Smith K, Levy B, Aikawa M, Baden L, Baslet G, Bennett L, Bhattacharyya S, Buring J, Cagnina R, Chen L, Clark C, Cohen P, Czeisler C, Estill P, Gay E, Hong J, Lamas D, Lay S, Levy-Carrick N, Manson J, Monafrared T, Redline S, Remis E, Schilkrut D, Sesso H, Solomon S, Sparks J, Spencer L, Systrom D, Thu P, Walt D, Washko G, Whittelsey M, Wiener R, Bassett I, Alba G, Aung T, Fitch K, Ginns L, Haas J, Hu Y, Juelg B, Kanjilal D, Kim A, Klerman E, Lewis G, Musa A, Ojikutu B, Perlis R, Rosand J, Wallace Z, Xerras D, Zionts D, Mullington J, Collier A, Fong T, Haack M, Hauser K, Maley J, Quintana Y, Shaughnessy L, Stephenson K, Thomas R, Torres R, Marathe J, Duffy E, Hamburg N, O'Connor G, Zhang H, John J, Ticotsky A, Ward H, Blazey-Martin D, Ghamloush M, Jordan M, Kogelman L, Marryshow T, Erdmann N, Levitan E, Tita A, Armstrong D, Binkley S, Blackwell K, Causey A, Cook F, Domingo J, Donahue C, Eady M, Edberg J, Forehand K, Frazier P, Garcia-McClaney N, Garner M, Gray B, Hall W, Hart C, Hebson C, Hidalgo B, Higgins B, Holtzapfel K, Horton G, Jinright A, Judd S, Kennedy T, Kirkwood L, Maier M, McCormack P, Mitchell K, Montgomery A, Nieters D, Peralta-Carcelen M, Pilco J, Powell L, Royster J, Shevin R, Skipworth S, Spurgeon L, Steele C, Vines J, Ware G, Wilson R, Woodruff D, Young B, Gillespie M, Daniel C, Hansel J, Wu J, Carton T, Miele L, Brown T, Sutherland E, Fuloria J, Datri P, Hagensee M, Leggio C, Perkins A, Trauth A, Trotter S, Van Deerlin A, Weiser S, Young M, Ashktorab H, Brim H, Laiyemo A, Sherif Z, Durrani S, Nezamloo A, Ngwa J, Njoku N, Gentil M, Mehari A, Solemani A, Chang L, Thuluvath P, Alemu M, Anderson J, Chauhan M, Cho S, Goodman K, Lanke G, Lebron R, Maheshwari A, Ok J, To C, Hodder S, Bardes J, Dominique-Villanueva D, Juskowich J, Reece R, Sarwari A, Shellito J, Greenway F, Kirwan J, Rodemann G, Rosen C, Arruda A, Brunet T, Emery I, Roelke T, Berger P, Black L, Hoover S, Tjarks B, Fonseca V, Gupta S, Longo M, Yang M, Shikuma C, Chow D, MarGangcuangco L, Castro M, Bengtson C, Howard T, Koontz B, Spikes L, Simmons C, Whiteheart S, Garvy B, Wood J, Marshall G, Garla V, Kuebler J, Nandi U, Vasey A, Warren D, Dickinson J, VanWagoner T, Bogie A, Heyanka D, James J, Scott J, Sukhera F, Luciano Roman C, Perez Frontera S, Santana Bagur J, Klein J, Krishnan J, Lin J, Muramatsu N, Prabhakar B, Prendergast H, Vanden Hoek T, Adams D, Baker A, Barbera S, Basu S, Bleasdale S, Boyd A, Breiter T, Buhimschi I, Carrithers M, Chalamalla R, Chestek D, Cook J, Darbar D, Dasgupta R, Davis Blakley F, DeLisa J, Diviak K, Donlon M, Dworkin M, Ellison A, Flanigan C, Freedman M, Gerald L, Giles W, Gordon H, Hammad B, Hasek S, Hasse W, Hryniewicka M, Illendula S, Ismail N, Jain A, Jennette K, Kadubek G, Kent D, Kent D, Kim K, Kotini-Shah P, Large L, Lash J, Lu J, Mahamed A, Malchenko S, Martinez M, Mauntel-Medici C, McCauley M, Menchaca M, Mermelstein R, Moreno D, Morrissy L, Musick H, Norwick L, Novak R, Ortiz M, Patel K, Perez N, Pliskin N, Pope S, Prasad B, Predki B, Quigley J, Ramchandran R, Ramirez A, Rappe S, Rehman J, Rowley M, Rudraraju G, Rutherfoord M, Sculley J, Smith-Mack J, Sun J, Tartt N, Villanueva L, Warfield Kelly S, Yazici C, Certa M, Chessier E, Everett E, Kindred E, Harris P, Sudhindra P, Olds L, Aponte-Soto L, Del Rios M, Diaz M, Ibanez A, Rolon C, Cranford S, Brown D, Dixon J, Gale L, Hammerl S, Hartwig K, Madineni A, Swearingen P, Hendrickson M, Noland S, Terlinde T, Hobbs B, Stewart de Ramirez S, Bolliger D, Boyineni J, Chebrolu P, Curry H, Donohue S, Edmonds S, Kelly S, Maholovich P, Sader S, Thompson T, Welter H, Woolley B, Hafner J, Hanson K, Hutton R, Charney A, Kovatch P, Merad M, Nadkarni G, Wisnivesky J, Aberg J, Ascolillo S, Bagiella E, Bartram L, Becker J, Beckmann N, Bendl A, Chen B, Civil A, Crawford G, Dhar K, Evo-Ortega L, Fierer D, Gallagher E, Garcia-Sastre A, Gnjatic S, Gray I, Guliyeva S, Harvey-Ingram L, Herrera-Moreno J, Hill M, Horowitz C, Jackson R, Kastrat D, Lala-Trindade A, Lin J, Macaluso N, Marcon K, Meyer D, Morinigo J, Natelson B, Nussenzweig M, Padua T, Putrino D, Richardson L, Russo S, Seifert A, Serri A, Walker J, Yee M, Bateman L, Hess R, Truong D, Alekhina N, Barlocker J, Brown J, Cortez M, Donohue D, Facelli J, Gouripeddi R, Hermansen J, Johnny J, Lindsay A, Lloyd J, Lu Y, Medina J, Morimoto S, Pace L, Rius D, Scholand M, Shah K, Sharareh N, Spivak A, Stringham C, Trinity J, Velinder M, Weaver L, West J, Vernon S, Deakyne Davies S, Gardner E, Buck K, Gonzalez Rivas E, Hawkins K, Oakes J, Sanchez Vazquez W, Horne B, Knowlton K, Woller S, Aguirre B, Anderson J, Bair T, Bosh L, Evans L, Garrett C, Harris D, Herrera K, Iverson L, Jensen M, Juan J, Knight S, Leither L, Maestas H, May H, Zubal S, Erlandson K, Sokol R, Brightman M, Davis D, Feuerriegel E, Fudge H, Garg L, Higgins J, Jolley S, Lockie T, McCandless S, Pitch C, Reusch J, Thurman B, Tran H, West S, Friedman N, Ludwig K, Decker L, Raissy H, Adolphi N, Archuleta D, Bradfute S, Brito R, Elifritz J, Garcia-Soberanez N, Gentry F, Harkins M, Martinez N, Montoya L, Parada A, Quinn D, Ramos A, Sheehan E, Treacher I, McComsey G, Adams C, Andrefsky J, Atieh O, Baissary J, Boldt N, Chemali K, Ciborek E, Conrad A, D’Anza B, Daher J, DiFrancesco K, Foster (Rodgers) T, Gallagher M, Gupta A, Harrill J, Harris P, Jacono F, Kelly J, Koberssy Z, Kumar R, Labbato D, Lim J, Pettinato K, Rodgers M, Rosolia B, Roy A, Sattiraju S, Scott S, Smith B, Tejani V, Tribout M, Yendewa G, Singer N, Ayache M, Barnboym E, Brown A, Chesnick H, Edminston M, Greenwood C, Haghiac M, Kaufman E, Lengu K, Lowenthal R, Malakooti S, Oleson C, Pearman A, Rizea A, Smith C, Washington M, Weinberger E, Heath J, Brennan C, Edmark R, Gutierrez V, Hadlock J, Li S, Magis A, McDonald C, Murray K, Rowen L, Yuan D, Chen P, Banitaba A, Caudill A, Chopra T, Dahlke L, Diaz M, Gudipudi L, Jackman S, Mattison B, Modes M, Nelson C, Nwafor C, Parimon T, Pascual E, Salinas N, Torbati S, Watson S, Tuttle K, Alicic R, Baxter J, Emerson S, Hood S, Kuykendall K, White S, Wilcox L, Goldman J, Algren H, Del Alcazar J, Duven A, Kaneko J, Kim C, Manner P, Mason C, Okada A, Poussier R, Satira R, Wallick J, Chu H, Elias-Warren A, Harteloo A, Logue J, McCaffrey K, Nguyen H, Nambiar A, Patterson T, Potter J, Salehi M, Sharma K, Verduzco-Gutierrez M, Anderson R, Arellanes A, Barajas R, Chauhan S, Clarke G, Farner C, Fischer M, Goldberg M, Hastings G, Heard P, Hernandez J, Herrera I, Infante E, Johnson H, Jones J, Kellogg D, Kraig E, Longoria L, Okafor E, Patterson J, Pinones A, Reeves W, Scholler I, Seshadri S, Shah P, Shah D, Smith M, Soileau B, Solis P, Stoebner C, Sullivan M, Taylor B, Tragus R, Tsevat J, Hasbani K, Saade G, Hernandez Martinez G, Recabarren C, Sharma K, Paredes C, Alvarado S, Kumar A, Maldonado Y, Utz P, Blish C, Go M, Jagannathan P, Singh U, Ahuja N, Blomkalns A, Bonilla H, Brotherton R, Clinton K, Dingankar V, Geng L, Haddad F, Jamero C, Jee K, Jia X, Khurana N, Miglis M, O'Conor E, Olszewski K, Pathak D, Quintero O, Saperia C, Scott J, Urdaneta A, Varkey M, Nikolich J, Parthasarathy S, Ernst K, Esquivel D, Harris D, Harris S, Hernandez M, Hsu H, James M, Karnafel M, Knox K, Koleski A, LaFleur B, Lambert B, LaRue S, Lutrick K, Merchant N, Morton C, Mosier J, Olorunnisola T, Peralta J, Pilling W, Pogreba-Brown K, Rischard F, Ryan L, Smith T, Snyder M, Subbian V, Suhr K, Reiman E, Lee-Iannotti J, Autry L, Beydoun H, Borwege S, Copeland J, DiLise-Russo M, Fadden S, Gomez I, Grischo G, Hartley W, Hillier L, Ismail H, Iusim S, Kala M, Kim D, Murthy G, Unzek S, Vadovicky S, Veres S, Bime C, Hansen L, Hughes T, Khalid S, Lieberman D, Soto F, Wilson C, Zapien A, Deeks S, Kelly J, Martin J, Peluso M, Anderson G, Anglin K, Argueta U, Asare K, Buitrago M, Chang Song C, Clark A, Conway E, Del Castillo N, Deswal M, Durstenfeld M, Eilkhani E, Eun A, Fehrman E, Figueroa T, Flores D, Grebe H, Henrich T, Hoh R, Hsue P, Huang B, Ibrahim R, Kerbleski M, Kirtikar R, Lew M, Lombardo J, Lopez M, Luna M, Marquez C, Munter S, Ngo L, Pineda-Ramirez J, Prather A, Rhoads K, Rodriguez A, Romero J, Ryder D, So M, Somsouk M, Tai V, Tran B, Uy J, Valdivieso D, Verma D, Williams M, Zamora A, Flaherman V, Jacoby V, Araya N, Arellano-Mechor C, Basi Y, Chang A, Christopher L, De La Torre I, Gade S, Guerreros E, Laleau V, Martin Herz S, Monzon V, Oceguera Barragan Y, Rait M, Salem M, Tolentino M, Metz T, Lamb D, Mcfarland E, Nelsen A, Phillips K, Schlater S, Sharma J, Sowles A, Valencia Vazquez J, Zaldivar M, Rouse D, Allard D, Beati L, DeMartino A, Lefebvre H, Milano J, Miller E, Hoffman M, Kitto C, Vanneman A, Reddy U, Bousleiman S, Eccheveri S, Gutierrez Y, Loffredo M, Perez A, Ravi R, Zork N, Hughes B, Ferrara J, Longo M, Mitchell M, Esplin M, Palatnik A, Karasti M, Peterson Z, Saffian E, Wiegand S, Fennig K, Snow E, Skupski D, Pao R, Patel R, Zaw H, Plunkett B, Anglemire K, Kapogiannis C, Kearns K, Suresh S, Yee L, Brinson M, Jones^ D, Kominiarek M, Mallett G, Reynolds T, Williams E, Palomares K, Beche I, Graziano-Carrete D, Perez C, Clifton R, Barrett K, Mullowney C, Sandoval G, Weiner S, Gibson K, Dalton W, Desantis B, Gill-Jones P, Pierse A, Polito L, Rosolowski B, Sweet E, Costantine M, Bartholomew A, Cackovic B, Dembroski C, Grobman W, Klopfenstein B, Mast D, McDaniel K, Paglione M, Rigsby C, Hackney^ D, Tita A, Armstrong D, Burrell N, Casey B, Dunn D, Mann M, Hoffman M, Docter O, Fischer L, Phipers J, Thorp J, Clark K, Leatherland M, Timlin S, Parry S, Filipczak A, Long E, McCabe M, Pizzi C, Simhan H, Bauer E, Boyce J, Facco F, Hankle S, Hines R, Hohn M, Muthukrishnan A, Sciurba F, Vargo J, Pacheco L, Cornwell J, DeVolder J, Nounes A, Salazar A, Thibodeaux L, Mendez-Figueroa H, Ortiz F, Rugerio J, Treadway J, Beamon C, Dufresne I, Grinnan C, Phillips H, Pettker C, Perley L, Rink L, Newman L, Abella J, Barnette Q, Bevc C, Beverly J, Ceger P, Croxford J, Cunningham E, Enger M, Fain K, Farris T, Hanlon S, Hines D, Johnson-Lawrence V, Jordan K, Lefebvre C, Linas B, Luukinen B, Mandal M, McKoy N, Nance S, Oakland A, Pasquarelli D, Quiner C, Sembajwe R, Shaw G, Thornburg V, Tosco K, Wright H, Gross R, Hochman J, Horwitz L, Katz S, Troxel A, Adler L, Akinbo P, Almenana R, Bello O, Bhuiyan S, Blachman N, Branski R, Briscoe J, Brosnahan S, Bueler E, Burgos Y, Caplin N, Chaplin D, Chen Y, Cheng S, Choe P, Choi J, Chung A, Church R, Cobos S, Croft N, Cruz Irving A, Del Boccio P, Díaz I, Doshi V, Ebel S, Faustin A, Febres E, Fine J, Fink S, Frontera J, Gallagher R, Gonzalez-Duarte A, Hasson D, Hill S, Islam S, Johnson S, Kansal N, Kenney R, Kewlani D, Lamendola-Essel M, Laynor G, Leon T, Lewczak Z, Linton J, Logan M, Malik N, Mamistvalova L, Mandel H, Maranga G, Mathews P, Mattoo A, Mei T, Mendelsohn A, Mercier E, Millar Vernetti P, Miller M, Mitchell M, Moreira A, Mudumbi P, Nahin E, Nair N, Nekulak J, Owens K, Parent B, Patibandla N, Petrov P, Postelnicu R, Randall I, Rao P, Rapkiewicz A, Rizzo J, Rosas J, Rose C, Saint-Jean C, Santacatterina M, Shah B, Shaukat A, Simon N, Simsir A, Stinson M, Tang W, Tatapudi V, Thawani S, Thomas M, Thorpe L, Tom M, Treiha E, Truong J, Udosen M, Velazquez-Perez J, Vernetti P, Vidal C, Viswanathan A, Wong C, Wood M, Wuller S, Yin S, Young C, Zaretsky J, Zavlunova S, Foulkes A, Karlson E, Murphy S, Ahirwar S, Ahmed S, Ainsworth L, Atchley-Challenner R, Avilach P, Balan T, Benik N, Benoit B, Bind M, Bonaventura W, Boutin N, Brion B, Cagan A, Cai T, Cao T, Castro V, Cerretani X, Chan J, Cheng D, Chibnik L, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Guan Z, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Krishnamoorthy A, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Morse R, Nazaire M, Neils G, Nguyen A, Norman J, Paik H, Pant D, Park H, Rabideau D, Reeder H, Rossi-Roh K, Santacroce L, Schlepphorst K, Schulte C, Selvaggi C, Shinnick D, Simons W, Simpson L, St. Jean Flanders M, Strasser Z, Thakrar M, Thaweethai T, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang T, Wattanasin N, Weber G, Williams M, Zhang R, Cicek M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Blancero F, Brown H, Carmilani M, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Burns J, Spudich S, Bailey C, Cortez M, Foulkes A, Goff D, Lasky-Su J, Ofotokun I, Stockwell M, Stone J, Taylor B, Utz P, Williams N, Warburton D, Davis H, Erdmann N, Gage Witvliet M, Jain M, Martinez T, McGrath R, Rutter J, Bishof K, Dumitriu D, Goepfert P, Goldman S, Hewitt S, Huentelman M, Karp B, 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Taylor E, Taylor K, Terry D, Wallace A, Warner J, White B, Wilensky R, Williams M, Williams N, Williams-Dawson K, Wylam A. Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort. JAMA Network Open 2025, 8: e2533815. PMID: 40996759, PMCID: PMC12464792, DOI: 10.1001/jamanetworkopen.2025.33815.Peer-Reviewed Original ResearchCitationsAltmetric
Clinical Trials
Current Trials
Are you are currently experiencing brain fog from Long COVID?
IRB ID2000031278RoleSub InvestigatorPrimary Completion Date09/30/2026Recruiting ParticipantsVolunteers Needed for HIV & Health Study (HARC Plus)
IRB ID1502015318RolePrincipal InvestigatorPrimary Completion Date06/01/2025Recruiting ParticipantsEstablish and Characterize an Acute HIV Infection Cohort in a High Risk Population
IRB ID1111009338RolePrincipal InvestigatorPrimary Completion Date12/10/2021Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
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Activities
activity Investigations in CNS HIV Reservoirs and HIV Cure
01/01/2013 - PresentResearchDetailsBangkok, ThailandAbstract/SynopsisA range of project in collaboration with investigators at SEARCH Thailand as well as from multiple US and international institutions to assess potential reservoirs for HIV in the nervous system as well as the impact of therapeutic interventions aimed to reduce HIV in the brain.
activity Effects of Acute HIV Infection in the Central Nervous System
01/01/2011 - PresentResearchDetailsBangkok, ThailandAbstract/SynopsisClinical and translational research investigating the nervous system during acute HIV infection, and the impact of early antiretroviral therapy.
Clinical Care
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Overview
Serena Spudich, MD, MA, is one of only a few neurologists in the United States with specialized training in infections of the nervous system and a clinical practice focusing on neurological issues in patients with HIV.
She primarily cares for patients with HIV who suffer from such neurological problems as cognitive disturbances, memory loss and infections. “Many of these are directly related to HIV,” she says. In addition, she consults with patients who have such infections of the nervous system as Lyme disease and West Nile virus, and those with general neurological disorders.
A professor of neurology at Yale School of Medicine and division chief of neurological infections and global neurology, Dr. Spudich strongly believes patients can lead longer and healthier lives when HIV is diagnosed and treated early. “The example that one patient has proven to be cured of HIV, which was previously thought to be an ‘incurable’ disease, brings hope to the 37 million people worldwide infected with HIV, and to those with other chronic infections that impact the brain,” she says.
Clinical Specialties
Fact Sheets
Human Immunodeficiency Virus (HIV)
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News
- February 24, 2025
NIMH Grant Advances Research into Long COVID and Related Brain Changes
- July 22, 2024
New Evidence Supports Autoimmunity as One of Long COVID’s Underlying Drivers
- July 10, 2024
Highlighting Yale’s Neuroscience Research
- May 29, 2024Source: Yale Medicine
Long COVID Brain Fog: What It Is and How to Manage It
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Locations
Neuroinfectious Disease Research Program
Lab
135 College Street, Fl 3
New Haven, CT 06510
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.