Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsMary Jane Minkin, MD, FACOG
Clinical ProfessorAbout
Research
Publications
2026
Neurokinin pathway botanical antagonist for menopausal vasomotor symptoms: A randomized, double-blind, placebo-controlled study
Lederman S, Minkin M, Doyle A, Rubio J, Recker S, Lin L, VanDusseldorp T. Neurokinin pathway botanical antagonist for menopausal vasomotor symptoms: A randomized, double-blind, placebo-controlled study. Maturitas 2026, 211: 109023. PMID: 42284819, DOI: 10.1016/j.maturitas.2026.109023.Peer-Reviewed Original ResearchHot Flash Related Daily Interference ScaleMenopause-specific quality of lifeVasomotor symptomsDouble-blindSustained reliefPittsburgh Sleep Quality IndexMenopausal womenHot flashesRelief of vasomotor symptomsPlacebo-controlled studyPlacebo-controlled trialLiver function abnormalitiesReceptor signaling in vivoManifestations of menopauseSubgroup of patientsMenopausal vasomotor symptomsSevere hot flashesNonpharmacologic treatment optionsVasomotor symptom frequencyPatient-reported outcome measuresSerum estradiolPrimary endpointSecondary endpointsNo significant differenceSerum estrogenReport of the FDA's expert panel on hormone therapy.
Pinkerton J, Simon J, Hodis H, Minkin M, Manson J, Levy B. Report of the FDA's expert panel on hormone therapy. Menopause The Journal Of The North American Menopause Society 2026 PMID: 42084927, DOI: 10.1097/gme.0000000000002768.Peer-Reviewed Original ResearchLocal vaginal estrogenVaginal estrogenHormone therapyBox warningRisks of menopausal hormone therapyMenopausal hormone therapyExpert panelRoute of administrationAdverse effectsEstrogen therapyMultidisciplinary groupMenopausal women's health.Menopause SocietyTiming of initiationEstrogenTherapyRisk profileFDAWomen's healthRiskProgestogenMenopauseDoseHormoneMenopause in Cancer Survivors
Minkin M, Larkin L, Lustberg M. Menopause in Cancer Survivors. Obstetrics And Gynecology Clinics Of North America 2026 DOI: 10.1016/j.ogc.2026.04.004.Peer-Reviewed Original Research
2025
“I did not recognize myself”: a mixed methods study to better understand the experiences of menopause in a US workplace
Mallen S, Coppola J, Shaffer N, Minkin M, Ward A, Snow S. “I did not recognize myself”: a mixed methods study to better understand the experiences of menopause in a US workplace. Menopause The Journal Of The North American Menopause Society 2025, 32: 920-929. PMID: 40591541, PMCID: PMC12502938, DOI: 10.1097/gme.0000000000002575.Peer-Reviewed Original ResearchThe Effects of a Non-Hormonal NK3R Antagonist Nutritional Supplement on Joint Discomfort and Quality of Life Parameters in Peri- and Postmenopausal Females
Alesi M, Mason L, Carbonneau S, Lederman S, Minkin M, Kviatkovsky S, Dweck A, VanDusseldorp T, Komorowski J. The Effects of a Non-Hormonal NK3R Antagonist Nutritional Supplement on Joint Discomfort and Quality of Life Parameters in Peri- and Postmenopausal Females. Current Developments In Nutrition 2025, 9: 106024. DOI: 10.1016/j.cdnut.2025.106024.Peer-Reviewed Original Research
2021
Weight gain in menopause: systematic review of adverse events in women treated with black cohosh
Naser B, Castelo-Branco C, Meden H, Minkin M, Rachoń D, Beer A, Pickartz S. Weight gain in menopause: systematic review of adverse events in women treated with black cohosh. Climacteric 2021, 25: 220-227. PMID: 34608830, DOI: 10.1080/13697137.2021.1973993.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdverse eventsWeight gainSpontaneous adverse eventsBody fat compositionScientific evidencePopular treatment optionPostmenopausal womenMenopausal womenMenopausal symptomsTreatment optionsCase reportTreatment groupsSystematic reviewBlack cohoshFat compositionWeight changeWomenSignificant differencesFrequent problemPerimenopausalMenopauseReviewGroupSymptomsCases
2020
Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence
Castelo-Branco C, Gambacciani M, Cano A, Minkin M, Rachoń D, Ruan X, Beer A, Schnitker J, Henneicke-von Zepelin H, Pickartz S. Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence. Climacteric 2020, 24: 109-119. PMID: 33021111, DOI: 10.1080/13697137.2020.1820477.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClimacteric symptomsMenopausal symptomsBetter benefit-risk profileLow-dose transdermal estradiolICR/Evidence-based treatment optionsEstrogen-sensitive organsEstrogen-sensitive tissuesPsychological menopausal symptomsMinor adverse eventsBenefit-risk profileEvidence of hepatotoxicityGood safety profileStandardized mean differenceHormone-dependent diseasesSystematic literature searchTransdermal estradiolAdverse eventsGood tolerabilitySafety profileTreatment optionsSt. John's wortHerbal therapyHormone levelsClinical dataEffects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial
Black D, Minkin M, Graham S, Bernick B, Mirkin S. Effects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial. Menopause The Journal Of The North American Menopause Society 2020, 28: 32-39. PMID: 32932401, PMCID: PMC7769186, DOI: 10.1097/gme.0000000000001659.Peer-Reviewed Original ResearchConceptsE2/P4Diastolic blood pressureSystolic blood pressureBlood pressurePostmenopausal womenREPLENISH trialMonth 12Treatment-emergent adverse eventsWeight gainTwelve-month useHealthy postmenopausal womenSevere vasomotor symptomsBody mass indexAdverse eventsVasomotor symptomsMass indexEfficacy profileWomenBaselineHypertensionPlaceboUterusTrialsImportant changesPrevious findings
2019
The International Society for the Study of Women's Sexual Health Process of Care for the Identification of Sexual Concerns and Problems in Women
Parish S, Hahn S, Goldstein S, Giraldi A, Kingsberg S, Larkin L, Minkin M, Brown V, Christiansen K, Hartzell-Cushanick R, Kelly-Jones A, Rullo J, Sadovsky R, Faubion S. The International Society for the Study of Women's Sexual Health Process of Care for the Identification of Sexual Concerns and Problems in Women. Mayo Clinic Proceedings 2019, 94: 842-856. PMID: 30954288, DOI: 10.1016/j.mayocp.2019.01.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProcess of careFemale sexual dysfunctionSexual problemsSexual concernsSexual healthWomen's sexual healthPatient-centered communication skillsCaregivers of womenCommon sexual problemInternational expert panelInternational SocietySexual dysfunctionCommon disorderDistressing problemSexual painClinician expertiseSexual medicine specialistsMedicine specialistsClinical practicePatient needsClinical settingSexual medicineWomenExpert panelClinicians
2017
Sexuality, Sexual Dysfunction, and Menopause
Minkin M. Sexuality, Sexual Dysfunction, and Menopause. 2017, 165-171. DOI: 10.1007/978-3-319-42451-4_9.Peer-Reviewed Original ResearchVasomotor symptomsVulvovaginal atrophyLast menstrual periodPostmenopausal womenVaginal pHPhysical examinationMenstrual periodNew medicationsSexual dysfunctionLast examSexual healthSexual disinterestSexual activityMenopauseFemale ViagraSymptomsWomenSignificant changesYearsMedicationsPallorAtrophyDysfunctionTestosteroneVagina
Academic Achievements & Community Involvement
News
News
- June 30, 2026
Women’s Health Research at Yale and SWHR’s Symposium Highlights the Power of Collaboration to Advance Women’s Health Research
- June 25, 2026Source: Oprah Daily Online (with Mary Jane Minkin, MD)
Avoiding Hormone Therapy? You Could Be Missing a Major Bone Health Benefit
- May 13, 2026Source: Health Central
Dark Nipples: What Are the Causes?
- April 09, 2026Source: AARP (with Dr. Mary Jane Minkin)
8 Ways to Beat Menopausal Brain Fog