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Helen Pushkarskaya, PhD

Assistant Professor in Psychiatry
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Assistant Professor in Psychiatry

Biography

Helen Pushkarskaya is an Associate Research Scientist in the Department of Psychiatry, Yale School of Medicine and an Instructor (Introduction into Data Analysis and Econometrics) in the Department of Economics, Yale University. She has completed training in mathematics and physics (undergraduate training, Moscow Physics and Technology Institute), economics (graduate training, Ohio State University), psychology (postdoctoral training, Ohio State University), imaging and cognitive neurobiology (T32 fellowship, Yale School of Medicine), and clinical sciences (NIH K01 Career Development Award, Yale School of Medicine). Her research in multi-disciplinary and relies on complementary cross-sectional and longitudinal data using behavioral and fMRI experiments, online and paper-based surveys, semi-structured interviews, and clinical assessments. She is one of the organizers of the series MAPs: Methods And Primers for Computational Psychiatry and Neuroeconomics.

Research focus: A prominent view on the marked divergence in developmental paths is that individuals vary in their susceptibility to both negative (risk-promoting) and positive (development-enhancing) environmental conditions; this has been termed the differential susceptibility model, or DSM). The DSM has some risk of promoting a deterministic view and a stance of ‘blaming and changing’ the susceptible person to induce better coping with adverse environments. To avoid this trap, proponents of the DSM have argued for a more dynamic approach, suggesting that developmental vulnerability may vary across developmental stages and socio-economics environments, and that interventions need to mitigate vulnerabilities by promoting resilience instead of changing personality traits. Helen Pushkarskaya's research advocates for this approach. It aims to answer the following inter-related questions:

  • What are the differences between normal and abnormal variations in basic psychological, social, behavioral, and neurobiological processes, such as information processing and decision formation?
  • What differentiates and triggers adaptive and maladaptive developmental trajectories?
  • How do adaptive variations in information processing and decision-making fit in a broader socio-economics dynamic?
  • What are the social and clinical modifiers of healthy maturational and illness trajectories, and what are the risk and resilience factors?

The ultimate goal of this line of research is to identify how adaptive variations can be supported and maladaptive variations can be mitigated in order to influence social policies and early clinical interventions.

Last Updated on May 15, 2026.

Appointments

Other Departments & Organizations

Education & Training

PhD
Ohio State University (2003)

Research

Research at a Glance

Yale Co-Authors

Frequent collaborators of Helen Pushkarskaya's published research.

Publications

2026

  • Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
    Cardoso Saraiva L, Sato J, Sebenius I, Dzinalija N, del Río-Torné C, Godinho F, Lopes A, Fernandez T, Lima M, Ramos V, Iglesio R, Abe Y, Alonso P, Ameis S, Anticevic A, Araújo A, Arnold P, Balachander S, Banaj N, Batistuzzo M, Benedetti F, Bollettini I, Bravi B, Brennan B, Buitelaar J, Castelo-Branco M, Choi S, Costa A, Dallaspezia S, Denys D, Duarte I, Echevarria M, Eng G, Fernandes A, Feusner J, Figee M, Fitzsimmons S, Fontenelle L, Grazioplene R, Ha M, Hinojosa A, Hoexter M, Huijser C, Hu H, James A, Kim M, Kwon J, Lazaro L, Lochner C, Machado-Sousa M, van Marle H, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Minuzzi L, Morgado P, Muñoz-Moreno E, Nakao T, Narayanaswamy J, Nurmi E, O’Neill J, Park I, Phillips M, Piacentini J, Picó-Pérez M, Piras F, Piras F, Postma T, Li C, Reddy J, van Rooij D, Sakai Y, de Salles Andrade J, Scheffler F, Shivakumar V, Soreni N, Stern E, van der Straten A, Thomopoulos S, Tomiyama H, Tovar-Moll F, Vecchio D, Veltman D, Venkatasubramanian G, Vriend C, Wang Z, van der Werf Y, van Wingen G, Zhao Q, Charney A, Cho Y, Shavitt R, Pushkarskaya H, Soriano-Mas C, Romero-Garcia R, Thompson P, Stein D, van den Heuvel O, Winkler A, Miguel Filho E, Pittenger C, Cappi C. Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder. Nature Communications 2026 PMID: 42343090, DOI: 10.1038/s41467-026-74153-2.
    Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
  • COVID Diaries, State Response to COVID Vaccination Program, December 2020 to September 2021
    Moore A, Vitu B, Fraizer-Bisner F, Williams P, van der Merwe L, Gouda A, Kirilova D, Pittenger C, Pushkarskaya H. COVID Diaries, State Response to COVID Vaccination Program, December 2020 to September 2021. Scientific Data 2026, 13: 775. PMID: 41862527, PMCID: PMC13199395, DOI: 10.1038/s41597-026-06975-0.
    Peer-Reviewed Original Research
    This study investigates U.S. state responses to COVID-19 vaccination programs, analyzing 5,223 public documents to assess communication strategies' impact on vaccine uptake and public trust.
  • Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale
    Cheng A, Konova A, Powers A, Corlett P, Levy I, Gu X, Huys Q, Pushkarskaya H, Fineberg S, Hauser T, Chase H, Bzdok D, Harpaz-Rotem I, Babuscio T, Nichols L, Zhao Y, Sharma M, Meeker D, Xu H, Rutledge R, Pearlson G, Pittenger C, Yip S. Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2026 PMID: 41763489, DOI: 10.1016/j.bpsc.2026.02.009.
    Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

2025

2024

2022

2020

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Locations

  • Connecticut Mental Health Center

    Academic Office

    34 Park Street, Ste 332

    New Haven, CT 06519