Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsDavid Glahn, PhD
Professor Adjunct of PsychiatryDownloadHi-Res Photo
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Titles
Professor Adjunct of Psychiatry
Professor of Psychology
Biography
Dr. David Glahn joined Yale’s Department of Psychiatry and the Olin Neuropsychiatry Research Center in 2008. He received his doctorate in clinical psychology from the University of Pennsylvania in 2000 and completed a post-doctoral fellowship at the University of California at Los Angeles. From 2002 to 2008, Glahn was faculty at the University of Texas Health Science Center San Antonio, where he created a psychiatric genetics and imaging research program.
The primary aim of Glahn’s laboratory is to discover genes that predispose affective and psychotic disorders like major depression, bipolar disorder and schizophrenia. To achieve this aim, he develops and applies neuroanatomic, functional neuroimaging, and neurocognitive endophenotypes in large-scale family-based studies. Glahn co-direct the Neurocognition, Neurocomputation and Neurogenetics (n3) Division of the Department of Psychiatry at Yale University Medical School, and the Affective Disorders and Psychosis (ADAPTING) laboratory at the Olin Neuropsychiatric Research Center. In this capacity, he supervises an 11-strong research team comprised of junior faculty, postdoctoral fellows and research assistants. Glahn collaborates with investigators locally at Yale/Olin, nationally and internationally in connection to neuroimaging, neurocognition and genomic research.
Last Updated on April 07, 2025.
Departments & Organizations
- Glahn Lab
- Olin Neuropsychiatry Research Center
- Yale Global Mental Health Program
- Yale Ventures
Education & Training
- MA
- Yale University, Privatim (2015)
- Post-Doctoral Fellow
- University of California Los Angeles (2002)
- PhD
- University of Pennsylvania, Psychology (2000)
- MA
- University of Pennsylvania, Psychology (1997)
- BS
- Drexel University, Psychology (1993)
Research
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Overview
Medical Research Interests
Aging; Bipolar Disorder; Child Development; Depressive Disorder, Major; Genetics; Genetics, Behavioral; Neuroimaging; Neuropsychology; Psychiatry and Psychology; Schizophrenia
ORCID
0000-0002-4749-6977
Research at a Glance
Yale Co-Authors
Frequent collaborators of David Glahn's published research.
Publications Timeline
A big-picture view of David Glahn's research output by year.
Research Interests
Research topics David Glahn is interested in exploring.
Godfrey Pearlson, MA, MBBS
John Krystal, MD
John D Murray, PhD
Kevin Sheth, MD
Vince Calhoun, PhD
Alecia Dager, PhD
54Publications
263Citations
Schizophrenia
Neuroimaging
Child Development
Aging
Publications
2025
Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory
Hopkins L, Avgan N, Sutherland H, Fernandez F, Knowles E, Haupt L, Blangero J, Glahn D, Shum D, Lea R, Griffiths L. Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory. Scientific Reports 2025 PMID: 41413636, DOI: 10.1038/s41598-025-32828-8.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCognitive phenotypesVerbal learningAssociation studiesIntronic variantsMultiple cognitive domainsGenetic basisGenome wide significant associationComprehensive test batteryCognitive performance assessmentContribution of genetic variationCorrelating test scoresProspective memoryRetrospective memoryCognitive domainsTest batteryLearned discriminationCadherin pathwaysHuman cognitionSynonymous variantsGenetic variationUTR variantsTest scoresGenetic associationMemoryStructural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium
Lamsma J, Raine A, Kia S, Cahn W, Arold D, Banaj N, Barone A, Brosch K, Brouwer R, Brunetti A, Calhoun V, Chew Q, Choi S, Chung Y, Ciccarelli M, Cobia D, Cocozza S, Dannlowski U, Dazzan P, de Bartolomeis A, Di Forti M, Dumais A, Edmond J, Ehrlich S, Evermann U, Flinkenflügel K, Georgiadis F, Glahn D, Goltermann J, Green M, Grotegerd D, Guerrero-Pedraza A, Ha M, Hong E, Hulshoff Pol H, Iasevoli F, Kaiser S, Kaleda V, Karuk A, Kim M, Kircher T, Kirschner M, Kochunov P, Kwon J, Lebedeva I, Lencer R, Marques T, Meinert S, Murray R, Nenadić I, Nguyen D, Pearlson G, Piras F, Pomarol-Clotet E, Pontillo G, Potvin S, Preda A, Quidé Y, Rodrigue A, Rootes-Murdy K, Salvador R, Sim K, Skoch A, Spalletta G, Spaniel F, Stein F, Thomas-Odenthal F, Tikàsz A, Tomecek D, Tomyshev A, Tranfa M, Tsogt U, Turner J, van Erp T, van Haren N, van Os J, Vecchio D, Wang L, Wroblewski A, Nickl-Jockschat T. Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium. Molecular Psychiatry 2025, 1-10. PMID: 41339704, DOI: 10.1038/s41380-025-03365-7.Peer-Reviewed Original ResearchAltmetricConceptsStructural brain abnormalitiesPositive symptomsBrain abnormalitiesENIGMA Schizophrenia Working GroupInferior parietal lobule volumesDorsolateral prefrontal cortex volumesRegional gray matter volumePrefrontal cortex volumeWhite matter microstructural integrityGray matter volumeAssociated with aggressive behaviorTotal cortical volumeGlobal white matter integrityWhite matter integrityIllness insightConcurrent aggressionNeurobiological basisMatter volumeCortex volumeENIGMA consortiumLobule volumesMediation analysisHealthy control subjectsAggressive behaviorCortical volumeStructural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis
Gray J, Price L, Franklin C, Leonardo C, Chiang F, Choi K, Blangero J, Glahn D, Mayberg H, Fox P. Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis. Brain Organoid And Systems Neuroscience Journal 2025, 3: 96-106. DOI: 10.1016/j.bosn.2025.04.008.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVoxel-based morphometrySubgroup of MDD patientsSubgroups of MDDStructural equation modelingMDD patientsDepressive disorderResting-state functional magnetic resonance imagingAbnormalities of brain structureVoxel-based morphometry analysisFunctional magnetic resonance imagingMagnetic resonance imagingMDD patient groupGray matter densityBiomarkers of MDDNeuroimaging-based biomarkersClinical subgroupsMass-univariate analysesMass-univariate methodsMeta-analytic datasetNeuroimaging effectsNeuroimaging studiesMDDBrain areasBrain structuresMeta-analyticallyCorrigendum to “The burden of early onset psychosis: Diagnostic complexity, high comorbidity, and poor functioning in patients and their relatives” [Schizophr. Res. Volume 285, November 2025, Pages 165-174]
Mollon J, Lanzagorta N, Mathias S, Rodrigue A, Knowles E, Deaso E, Cadavid L, Saavedra J, Brownstein C, D'Angelo E, Gonzalez-Heydrich J, Ramírez P, Sarmiento E, Bustamante C, Walsh C, Almasy L, Nicolini H, Glahn D. Corrigendum to “The burden of early onset psychosis: Diagnostic complexity, high comorbidity, and poor functioning in patients and their relatives” [Schizophr. Res. Volume 285, November 2025, Pages 165-174]. Schizophrenia Research 2025, 285: 379. PMID: 41083323, DOI: 10.1016/j.schres.2025.10.006.Peer-Reviewed Original ResearchThe interplay between genomic copy number variants, sleep, and cognition in the general population
Poulain C, Tesfaye R, Douard E, Martineau J, Saci Z, Labbe A, Glahn D, Almasy L, Elsabbagh M, Huguet G, Jacquemont S. The interplay between genomic copy number variants, sleep, and cognition in the general population. Translational Psychiatry 2025, 15: 351. PMID: 41053002, PMCID: PMC12501278, DOI: 10.1038/s41398-025-03579-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCopy number variantsNeurodevelopmental disordersCognitive abilitiesGenomic copy number variantsMeasures of cognitive abilityEffect of copy number variantsSleep durationPoorer cognitive performanceExecutive functionCognitive phenotypesCognitive performanceRisk of insomniaSleep remainsGenome-wide levelRobust associationsSleep disturbanceCognitionIntolerant genesSleepSleep traitsGeneral populationU-shaped patternPleiotropic effectsUK BiobankInsomniaA Scalable Toolkit for Modeling 3D Surface-Based Brain Geometry
Im Y, Nabulsi L, Kang M, Thomopoulos S, Zuluaga A, Dale A, Karuk A, Di Giorgio A, Mwangi B, Gutman B, Overs B, Jaramillo C, McDonald C, Stein D, Cannon D, Glahn D, Hidalgo-Mazzei D, Pecheva D, Grotegerd D, Pomarol-Clotet E, Vieta E, Olie E, Chertó E, Sambataro F, Howells F, Scheffler F, Busatto G, Anmella G, Zunta-Soares G, Roberts G, Temmingh H, Gotlib I, Agartz I, Soares J, Karantonis J, Prisciandaro J, Fullerton J, Radua J, Savitz J, Houenou J, Sim K, Harada K, Berger K, Matsuo K, Yatham L, Westlye L, Eyler L, Furlong L, Klahn L, Hermesdorf M, Zanetti M, Kempton M, Sacchet M, Landen M, Wu M, Rosa P, Mitchell P, Parekh P, Salvador R, Kuplicki R, Sarró S, Rossell S, Van Rheenen T, Satterthwaite T, Kircher T, Hajek T, Dannlowski U, Caseras X, Zhao Y, Andreassen O, Thompson P, Ching C, for the ENIGMA Bipolar Disorder Working Group. A Scalable Toolkit for Modeling 3D Surface-Based Brain Geometry. Lecture Notes In Computer Science 2025, 16171: 232-246. DOI: 10.1007/978-3-032-06774-6_18.Peer-Reviewed Original Research58. A RARE, DELETERIOUS COPY NUMBER VARIANT CO-SEGREGATING WITH MAJOR DEPRESSIVE DISORDER IN A MEXICAN-AMERICAN PEDIGREE
Ormond C, Ryan N, Peralta J, Duggirala R, Kumar S, Heron E, Curran J, Glahn D, Blangero J, Corvin A. 58. A RARE, DELETERIOUS COPY NUMBER VARIANT CO-SEGREGATING WITH MAJOR DEPRESSIVE DISORDER IN A MEXICAN-AMERICAN PEDIGREE. European Neuropsychopharmacology 2025, 99: 84. DOI: 10.1016/j.euroneuro.2025.08.163.Peer-Reviewed Original ResearchConceptsCopy number variantsDeleterious copy number variantsMexican American pedigreesCo-segregationShort-read whole-genome sequencing dataWhole-genome sequencing dataRare copy number variantsProtein-coding genesGenome sequence dataVariants co-segregatedCalcium-dependent cell-cell adhesion glycoproteinCadherin gene familyCo-segregation analysisFamily-based studiesHeritable psychiatric disorderCo-segregation patternsDeleteriousness scoresShort readsGenome-wideSequence dataPsychiatric disordersCanonical transcriptsGene familyIntron/exon boundariesCalling methodsM33. PRELIMINARY FINDINGS FROM A CNV LINKAGE ANALYSIS OF A MEXICAN AMERICAN PEDIGREE COHORT
Ryan N, Ormond C, Peralta J, Duggirala R, Kumar S, Heron E, Curran J, Glahn D, Blangero J, Corvin A. M33. PRELIMINARY FINDINGS FROM A CNV LINKAGE ANALYSIS OF A MEXICAN AMERICAN PEDIGREE COHORT. European Neuropsychopharmacology 2025, 99: 125. DOI: 10.1016/j.euroneuro.2025.08.229.Peer-Reviewed Original ResearchConceptsCopy number variantsRare copy number variantsMajor depressive disorderLOD scoreMultiplex pedigreesInvestigations of copy number variantsCopy number variant lociGenetic variantsTwo-point LOD scoreIssues of population stratificationAssociated with psychiatric phenotypesMexican American pedigreesBipolar disorderPsychiatric disordersTwo-point linkageDiagnosis of major depressive disorderGenetics of Brain StructureContext of stressLinkage analysisGut-brain axisAmerican pedigreesPopulation stratificationMental illnessChromosome 1Stop codonThe burden of early onset psychosis: Diagnostic complexity, high comorbidity, and poor functioning in patients and their relatives
Mollon J, Lanzagorta N, Mathias S, Rodrigue A, Knowles E, Deaso E, Cadavid L, Saavedra J, Brownstein C, D'Angelo E, Gonzalez-Heydrich J, Ramírez P, Sarmiento E, Bustamante C, Walsh C, Almasy L, Nicolini H, Glahn D. The burden of early onset psychosis: Diagnostic complexity, high comorbidity, and poor functioning in patients and their relatives. Schizophrenia Research 2025, 285: 165-174. PMID: 41014919, DOI: 10.1016/j.schres.2025.09.022.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsEarly onset psychosisPsychiatric diagnosisPsychiatric comorbidityCognitive deficitsPoor functionGlobal Assessment of Functioning ScaleBrief Psychiatric Rating ScaleChildren's Global Assessment ScalePsychiatric Rating ScaleGeneral cognitive abilityStructured Clinical InterviewMultiple diagnosesGlobal Assessment ScaleAssociated with high comorbidityGlobal assessmentNonpsychotic diagnosesSCID-5DSM-VClinical InterviewCognitive abilitiesCognitive testsDiagnostic groupsRating ScalePsychosisHigher comorbidityAssociation of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program
Sarnowski C, Zhang Y, Ammous F, Shade L, DiCorpo D, Jian X, Arnett D, Austin T, Beiser A, Bis J, Blangero J, Boerwinkle E, Bressler J, Curran J, DeCarli C, Doddapaneni H, Dupuis J, Fardo D, Florez J, Gabriel S, Gibbs R, Glahn D, Gupta N, González H, González K, Hatzikotoulas K, Hayden K, Heckbert S, Hidalgo B, Huerta-Chagoya A, Hughes T, Kardia S, Kooperberg C, Launer L, Longstreth W, Mandla R, Mathias R, Morris A, Mosley T, Nasrallah I, Nyquist P, Psaty B, Qi Q, Raffield L, Rayner N, Reiner A, Satizabal C, Selvin E, Sevilla-Gonzalez M, Smith A, Smith J, Smith K, Snively B, Southam L, Sofer T, Suzuki K, Taylor H, Udler M, Viaud-Martinez K, Wassertheil-Smoller S, Wood A, Yanek L, Yin X, Manning A, Rotter J, Rich S, Meigs J, Fornage M, Seshadri S, Morrison A. Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program. Communications Biology 2025, 8: 1352. PMID: 40993182, PMCID: PMC12460837, DOI: 10.1038/s42003-025-08674-9.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTotal cranial volumeGeneral cognitive functionTrans-OmicsMetabolic syndromeCross-sectional studyCognitive functionNegative associationGenetic scoreSignificant negative associationPolygenic scoresDiverse cohortLateral ventricular volumeInsulin resistanceNeurological outcomeCognitive declineCross populationsFasting insulinCranial volumePrecision medicineObesityAssociationBrain sizeScoresBiological mechanismsOutcomes
Academic Achievements & Community Involvement
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Activities
activity Yale Scholar Awards Committee
05/03/2015 - PresentCommitteesMemberDetailsMemberactivity Yale Center for Clinical Investigation
04/30/2015 - PresentCommitteesMemberDetailsRevieweractivity Burlingame Award Selection Committee
04/30/2000 - PresentCommitteesMemberDetailsMemberactivity Monash Biomedical Imaging Center, Monash University
04/30/2012 - PresentCommitteesMemberDetailsMember, External Advisory Boardactivity Human Brain Mapping (Journal)
04/30/2015 - PresentPublic ServiceMemberDetailsEditorial Board
Honors
honor Joel Elkes Research Award
12/12/2016International AwardAmerican College of Neuropsychopharmacology (ACNP)DetailsUnited Stateshonor Independent Investigator Award
01/01/2013International AwardNational Alliance for Research on Schizophrenia and Depression (NARSAD)DetailsUnited Stateshonor Theodore Reich Research Award
05/01/2011International AwardInternational Society for Psychiatric GeneticsDetailsUnited Stateshonor A.E. Bennett Neuropsychiatric Research Award
05/01/2010International AwardSociety for Biological PsychiatryDetailsUnited Stateshonor Young Investigator Award
05/02/2005International AwardNational Alliance for Research on Schizophrenia and Depression (NARSAD)DetailsUnited States
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