Valentyna Kostiuk
Postgraduate AssociateAbout
Research
Publications
2025
Aortic calcification is associated with decreased abdominal aortic aneurysm growth
Olson S, Kostiuk V, Kim T, Curci J, Baxter T, Matsumura J, Blackwelder W, Terrin M, Guzman R. Aortic calcification is associated with decreased abdominal aortic aneurysm growth. Scientific Reports 2025, 15: 39112. PMID: 41203851, PMCID: PMC12594760, DOI: 10.1038/s41598-025-26407-0.Peer-Reviewed Original ResearchConceptsNon-invasive treatmentAortic calcificationNon-Invasive Treatment of Abdominal Aortic Aneurysm Clinical TrialProspective multicenter randomized studyRate of aneurysm growthAneurysm growthNon-Contrast Computed TomographySecondary cohort analysisAbdominal aortic calcificationBaseline calcium scoreAbdominal aortic aneurysm growthMulticenter randomized studyAortic aneurysm growthCause of morbidityAbdominal aortic aneurysm (AAA) ruptureSuperior mesenteric arteryMaximum transverse diameterCalcium scoreAgatston scoreCalcium burdenRandomized patientsRandomized studyMesenteric arteryUnivariate analysisRenal arteryArtificial Intelligence–Based Algorithms Improve Care of Patients with AAA
Kostiuk V, Rodriguez P, Loh S, Wilson E, Mojibian H, Fischer U, Ochoa Chaar C, Aboian E. Artificial Intelligence–Based Algorithms Improve Care of Patients with AAA. Annals Of Vascular Surgery 2025, 123: 207-214. PMID: 41061923, DOI: 10.1016/j.avsg.2025.09.046.Peer-Reviewed Original ResearchNatural language processingArtificial intelligence (AI)-based algorithmIntelligence-based algorithmsArtificial intelligence-based algorithmsSoftware deploymentAI utilizationMeasurement algorithmRadiology reportsPhone applicationAlgorithmTimely detectionProportion of patientsSoftwareLong-term follow-up careEvaluation timelineImagesImaging characteristicsFollow-up careAbdominal aortic aneurysm screeningDetectionImplementationLong-term follow-upFollow-upAbdominal aortic aneurysmAAA monitoringTMBIM4 affects left-right patterning via pluripotency exit during gastrulation
Diab N, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha M. TMBIM4 affects left-right patterning via pluripotency exit during gastrulation. Developmental Biology 2025, 527: 136-146. PMID: 40744297, DOI: 10.1016/j.ydbio.2025.07.018.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseCongenital heart disease patientsCongenital heart disease genesIon channelsPluripotency exitPluripotency marker expressionDeleterious genetic variationLR patterningCell fate determinationApplication of cholinePutative ion channelsCardiac asymmetryCongenital defectsMarker expressionEvolutionary conservationHeart diseaseGenomic studiesProtein 4Xenopus tropicalisGastrulation defectsFate determinationGenetic variationAsymmetry defectsTMBIM4Plasma membraneSurgical Specialties’ Outcomes for Carotid Body Tumor Resection
Fereydooni S, Kostiuk V, Fereydooni A, Judson B. Surgical Specialties’ Outcomes for Carotid Body Tumor Resection. Vascular And Endovascular Surgery 2025, 59: 815-820. PMID: 40650525, DOI: 10.1177/15385744251360824.Peer-Reviewed Original ResearchCarotid body tumor resectionCarotid body tumorModified Charlson Comorbidity IndexOperative timeLonger operative timeVascular surgeonsCompare 30-day postoperative outcomesCarotid body tumor surgeryAssociated with longer operative timeAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramMethodsA retrospective cohort analysisSurgical Quality Improvement ProgramHospital length of stayHospital stay durationSevere adverse eventsRetrospective cohort analysisCharlson Comorbidity IndexAssociated with increased oddsIncidence of hypertensionLength of stayQuality Improvement ProgramBody tumorsTumor resectionChallenging inferior vena cava filter removal complicated by strut penetration and prolonged dwell
Kostiuk V, Rodriguez P, Tonnessen B, Lozada J, Guzman R, Chaar C. Challenging inferior vena cava filter removal complicated by strut penetration and prolonged dwell. Journal Of Vascular Surgery Cases And Innovative Techniques 2025, 11: 101894. PMID: 40778295, PMCID: PMC12329293, DOI: 10.1016/j.jvscit.2025.101894.Peer-Reviewed Original ResearchInferior vena cavaInferior vena cava filter removalFilter removalAnticoagulant therapyStrut penetrationProximal right common iliac arteryPlacement of inferior vena cavaRight common iliac arteryFilter strut penetrationPulmonary embolism preventionInferior vena cava wallCommon iliac arteryL4 vertebral bodyEmbolism preventionFrequent complicationVena cavaFilter retrievalIliac arteryPatient's symptomsSurrounding organsVertebral bodyTemporary placementPatientsAnticoagulationTherapyAdherence to SVS Abdominal Aortic Aneurysm Guidelines Among Patients Detected by AI-Based Algorithm
Wilson E, Yao K, Kostiuk V, Bader J, Loh S, Mojibian H, Fischer U, Ochoa Chaar C, Aboian E. Adherence to SVS Abdominal Aortic Aneurysm Guidelines Among Patients Detected by AI-Based Algorithm. Annals Of Vascular Surgery 2025, 120: 108-114. PMID: 40349830, DOI: 10.1016/j.avsg.2025.05.007.Peer-Reviewed Original ResearchAbdominal aortic aneurysmAdherent patientsSurgical interventionAbdominal aortic aneurysm patientsNon-adherent patientsTertiary care centerFollow-up adherenceFollow-up algorithmSVS guidelinesImaging surveillanceSurgical criteriaAneurysm sizeAortic aneurysmIdentified patientsPati entsSurveillance adherenceVascular providersImaging scansDeceased patientsPatientsPhysician evaluationCare centerPatient outcomesStatistical significanceNo significant age differencesCACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis
Kostiuk V, Kabir R, Akbari R, Rushing A, González D, Kim A, Kim A, Zenisek D, Khokha M. CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis. Genesis 2025, 63: e70009. PMID: 40008628, PMCID: PMC11867209, DOI: 10.1002/dvg.70009.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseCACNA1GLow-voltage-activated calcium channelsExpression of Cacna1gCalcium channelsPatient cohortCardiac functionLR patterningHeterotaxyLR organizerChannel familyCACNA1SHeart diseaseLeft-rightG expressionXenopus tropicalisAbnormal expressionProcess of cilia formationCardiac loopingMultiple organsSignaling cascadesLR asymmetryPatientsT-typeEmbryonic developmentNup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427
Kostiuk V, Kabir R, Levangie K, Empke S, Morgan K, Owens N, Lusk C, Khokha M. Nup107 contributes to the maternal-to-zygotic transition by preventing the premature nuclear export of pri-miR427. Development 2025, 152: dev202865. PMID: 39791357, PMCID: PMC11829755, DOI: 10.1242/dev.202865.Peer-Reviewed Original ResearchConceptsMaternal transcriptsMaternal-to-zygotic transitionMaternal RNA clearanceZinc-finger transcription factorDegradation of maternal transcriptsEctodermal cell fatesMaternal-zygotic transitionNuclear pore complexNucleoporin functionZygotic transcriptionNuclear exportTranscript stabilityCell fateNuclear retentionTranscription factorsPore complexNup107TranscriptionEarly embryosRecognition sitesRNA clearanceGastrulationGerm layersTime course
2024
Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions
Kostiuk V, Fereydooni S, Setia O, Loh S, Strosberg D, Tonnessen B, Chaar C, Aboian E. Comparative analysis of negative pressure wound therapy (PICO) and standard dressing application after arterial vascular reconstructions. Vascular 2024, 33: 1304-1310. PMID: 39460535, DOI: 10.1177/17085381241296606.Peer-Reviewed Original ResearchGroin wound complicationsWound complicationsNegative pressure wound therapyNegative pressure therapyVascular reconstructionGroin dissectionPressure therapyPICO dressingIncidence of groin wound complicationsProcedure indicationArterial reconstructionWound therapyIncidence of wound complicationsReduction of wound complicationsMultivariate logistic regression analysisAssociated with lower riskSurgical site infectionAntibiotics post-operativelyFemoral artery dissectionOpen vascular reconstructionLogistic regression analysisSzilagyi classificationGroin surgerySite infectionPatient demographicsRuptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica
Kostiuk V, Rodriguez P, Aboian E, Kuwayama D, Guzman R, Chaar C. Ruptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica. Vascular And Endovascular Surgery 2024, 59: 411-415. PMID: 39438778, DOI: 10.1177/15385744241296220.Peer-Reviewed Original ResearchCommon iliac artery aneurysmsIliac artery aneurysmsAbdominal aortic aneurysmArtery aneurysmRenal artery originsKidney transplantationAortic aneurysmEndovascular repairAneurysm repairArtery originLeft common iliac artery aneurysmConcomitant abdominal aortic aneurysmNon-contrast CT scanComplex aneurysm anatomyComplex aortoiliac aneurysmsIntra-abdominal aneurysmsFemoral-femoral bypassRinged PTFE graftEndovascular aneurysm repairKidney transplant functionFunctioning kidney transplantExternal iliac arteryRisk of ruptureSciatica symptomsAortoiliac aneurysms