David Zenisek, PhD
Professor of Cellular And Molecular Physiology, of Ophthalmology and Visual Science and of NeuroscienceDownloadHi-Res Photo
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About
Titles
Professor of Cellular And Molecular Physiology, of Ophthalmology and Visual Science and of Neuroscience
Appointments
Cellular & Molecular Physiology
ProfessorPrimaryNeuroscience
ProfessorSecondaryOphthalmology
ProfessorSecondary
Other Departments & Organizations
- Cellular & Molecular Physiology
- Graduate Program in Cellular and Molecular Physiology
- Interdepartmental Neuroscience Program
- Kavli Institute for Neuroscience
- Molecular Medicine, Pharmacology, and Physiology
- Neuroscience
- Neuroscience Track
- Ophthalmology
- Program in Translational Biomedicine (PTB)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
Education & Training
- PhD
- State University of New York (1998)
Research
Overview
Medical Research Interests
Cell Biology; Endocytosis; Exocytosis; Ophthalmology; Physiology; Presynaptic Terminals; Retinal Bipolar Cells
ORCID
0000-0001-6052-0348
Research at a Glance
Yale Co-Authors
Frequent collaborators of David Zenisek's published research.
Publications Timeline
A big-picture view of David Zenisek's research output by year.
Research Interests
Research topics David Zenisek is interested in exploring.
Erdem Karatekin, PhD
Valentyna Kostiuk
Courtney Frederick
Mustafa Khokha, MD
Ane Landajuela Larma
Joseph Santos-Sacchi, PhD
31Publications
980Citations
Exocytosis
Presynaptic Terminals
Retinal Bipolar Cells
Endocytosis
Publications
2025
CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis
Kostiuk V, Kabir R, Akbari R, Rushing A, González D, Kim A, Kim A, Zenisek D, Khokha M. CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left‐Right Patterning in Xenopus tropicalis. Genesis 2025, 63: e70009. PMID: 40008628, PMCID: PMC11867209, DOI: 10.1002/dvg.70009.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCongenital heart diseaseCACNA1GLow-voltage-activated calcium channelsExpression of Cacna1gCalcium channelsPatient cohortCardiac functionLR patterningHeterotaxyLR organizerChannel familyCACNA1SHeart diseaseLeft-rightG expressionXenopus tropicalisAbnormal expressionProcess of cilia formationCardiac loopingMultiple organsSignaling cascadesLR asymmetryPatientsT-typeEmbryonic development
2024
Presynaptic Proteins and Their Roles in Visual Processing by the Retina
Thoreson W, Zenisek D. Presynaptic Proteins and Their Roles in Visual Processing by the Retina. Annual Review Of Vision Science 2024, 10: 347-375. PMID: 38621251, PMCID: PMC11536687, DOI: 10.1146/annurev-vision-101322-111204.Peer-Reviewed Original ResearchCitationsConceptsExtract critical featuresGanglion cellsHorizontal cellsRetinal ganglion cellsDendritic synapsesSynaptic feedbackSpatial frequencySynaptic connectionsRetinaBipolar cellsSynapse typesVisual worldSense of visionRibbon synapsesPresynaptic moleculesMotion directionTemporal frequencyCritical featuresPhotoreceptorsPresynaptic proteinsCellsRapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals
Perez C, Dudzinski N, Rouches M, Landajuela A, Machta B, Zenisek D, Karatekin E. Rapid propagation of membrane tension at retinal bipolar neuron presynaptic terminals. Biophysical Journal 2024, 123: 380a. DOI: 10.1016/j.bpj.2023.11.2322.Peer-Reviewed Original Research
2023
The Effects of Aging on Rod Bipolar Cell Ribbon Synapses
Shrestha A, Rameshkumar N, Boff J, Rajmanna R, Chandrasegaran T, Frederick C, Zenisek D, Vaithianathan T. The Effects of Aging on Rod Bipolar Cell Ribbon Synapses. Cells 2023, 12: 2385. PMID: 37830599, PMCID: PMC10572008, DOI: 10.3390/cells12192385.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsRod bipolar cellsRibbon synapsesSynaptic ribbonsCalcium currentBipolar cellsRetinal ganglion cellsAge-related morphological changesBipolar cell ribbon synapsesBipolar cell terminalsGlobal health concernAge-related visual impairmentAge-related changesPlexiform layerGanglion cellsInner nuclearCochlear cellsSensory alterationsCell terminalsVisual impairmentFunctional changesHealth concernCalcium signalsSynapsesCalcium dynamicsRetinaAuthor Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Author Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2023, 14: 3264. PMID: 37277326, PMCID: PMC10241910, DOI: 10.1038/s41467-023-39025-z.Peer-Reviewed Original ResearchAltmetricRibbon Synapses and Retinal Disease: Review
Frederick C, Zenisek D. Ribbon Synapses and Retinal Disease: Review. International Journal Of Molecular Sciences 2023, 24: 5090. PMID: 36982165, PMCID: PMC10049380, DOI: 10.3390/ijms24065090.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsMeSH Keywords and ConceptsConceptsPresynaptic protein complexesRibbon synapsesDefective synaptic transmissionMolecular machineryProtein complexesRetinal malfunctionSynaptic transmissionRetinal diseasesSynaptic ribbonsNeurotransmitter releaseMuscular dystrophyVisual diseaseSynapsesDiseaseSensory informationMutagenesisMachineryPresent understandingSynaptopathyVisual systemReviewPathogenesisRetinaPathologyCorrection: Mesnard et al. Eliminating Synaptic Ribbons from Rods and Cones Halves the Releasable Vesicle Pool and Slows Down Replenishment. Int. J. Mol. Sci. 2022, 23, 6429
Mesnard C, Barta C, Sladek A, Zenisek D, Thoreson W. Correction: Mesnard et al. Eliminating Synaptic Ribbons from Rods and Cones Halves the Releasable Vesicle Pool and Slows Down Replenishment. Int. J. Mol. Sci. 2022, 23, 6429. International Journal Of Molecular Sciences 2023, 24: 1561. PMID: 36675323, PMCID: PMC9863641, DOI: 10.3390/ijms24021561.Peer-Reviewed Original Research
2022
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2022, 13: 6681. PMID: 36335122, PMCID: PMC9637099, DOI: 10.1038/s41467-022-34363-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPluripotent cellsAdult tissue homeostasisCell fate commitmentDifferentiated cell fatesLeft-right patterningPluripotent embryonic cellsHuman embryonic stem cellsTemporal transcriptome analysisGene regulatory networksExpense of differentiationEmbryonic stem cellsGerm layer differentiationMembrane depolarizationFate commitmentPluripotent stateCell fateTranscriptome analysisRegulatory networksMyogenic lineageEmbryonic developmentTissue homeostasisDifferentiated fateEmbryonic cellsCandidate genesPluripotencyRapid membrane flow at a presynaptic terminal
Perez C, Dudzinski N, Rouches M, Machta B, Zenisek D, Karatekin E. Rapid membrane flow at a presynaptic terminal. Biophysical Journal 2022, 121: 230a. DOI: 10.1016/j.bpj.2021.11.1599.Peer-Reviewed Original Research
2021
Dynamics of Membrane Tension and Synaptic Vesicle Recycling
Perez C, Dudzinski N, Rouches M, Machta B, Zenisek D, Karatekin E. Dynamics of Membrane Tension and Synaptic Vesicle Recycling. Biophysical Journal 2021, 120: 323a. DOI: 10.1016/j.bpj.2020.11.2037.Peer-Reviewed Original ResearchCitations
News
News
- September 26, 2022
Yale Vision Core Grant from the National Institute of Health Has Been Renewed
- January 09, 2020
Cellular and Molecular Physiology Annual Retreat 2019
- December 06, 2018
Cellular and Molecular Physiology Annual Retreat 2018
- October 02, 2017
Cellular and Molecular Physiology Annual Retreat 2017
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