Shavanie Prashad
Postdoctoral Fellow in the Child Study CenterAbout
Research
Publications
2020
RNA-binding proteins in neurological development and disease
Prashad S, Gopal PP. RNA-binding proteins in neurological development and disease. RNA Biology 2020, 18: 972-987. PMID: 32865115, PMCID: PMC8216196, DOI: 10.1080/15476286.2020.1809186.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRNA-binding proteinGene expressionDisease-linked RNA-binding proteinsHigh-throughput transcriptomic analysisRNA processing stepsAberrant RNA metabolismAberrant RNA processingRecent exciting studiesRNA processingRNA metabolismMRNA traffickingAlternative splicingMultifunctional proteinTranscriptomic analysisSplicing misregulationMRNA stabilityMolecular mechanismsProtein resultsNeuronal homeostasisNeurodevelopmental defectsNeuronal proteinsFunctional consequencesPleiotropic effectsSpatiotemporal controlProteinPhosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo
Jang S, Xuan Z, Lagoy RC, Jawerth LM, Gonzalez IJ, Singh M, Prashad S, Kim HS, Patel A, Albrecht DR, Hyman AA, Colón-Ramos DA. Phosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo. Biophysical Journal 2020, 120: 1170-1186. PMID: 32853565, PMCID: PMC8059094, DOI: 10.1016/j.bpj.2020.08.002.Peer-Reviewed Original ResearchConceptsSubcellular compartmentsDynamic subcellular localizationPhase-separated condensatesNormoxic conditions resultsLiquid-like propertiesCaenorhabditis elegansCryptochrome 2Subcellular localizationBiochemical regulationEnergy stressGlycolytic enzymesInternal molecular rearrangementsVivoCompartmentsElegansLocalizesSubcompartmentsMolecular rearrangementSpheroid shapeEnzymeRegulationPFKPhosphofructokinaseRecruitmentConditions results