Shiwani Mahajan, MBBS, MHS
Clinical FellowAbout
Research
Publications
2026
Social Determinants of Health and Cardiovascular Health Across Female Life Stages: Reproductive vs Midlife Women in the National Health Interview Survey
Nriagu B, Mahajan S, Kwapong Y, Ayedun S, Faizan H, Tahir M, Metlock F, Dastmalchi L, Javed Z, Sharma G. Social Determinants of Health and Cardiovascular Health Across Female Life Stages: Reproductive vs Midlife Women in the National Health Interview Survey. American Journal Of Preventive Cardiology 2026, 101552. DOI: 10.1016/j.ajpc.2026.101552.Peer-Reviewed Original ResearchFollow-Up Assessment of Adherence to Methodological Standards in National Inpatient Sample Research
Dhingra L, Pedroso A, Aminorroaya A, Caraballo C, Mahajan S, Bansal B, Krumholz H, Khera R. Follow-Up Assessment of Adherence to Methodological Standards in National Inpatient Sample Research. JAMA Network Open 2026, 9: e2555753. PMID: 41591780, PMCID: PMC12848622, DOI: 10.1001/jamanetworkopen.2025.55753.Peer-Reviewed Original Research
2025
Trends in Prevalence, Treatment, and Relationship of Metabolic Syndrome and Individual Components by Race/Ethnicity, 1999-2018
Lu Y, Li X, Liu Y, Caraballo C, Massey D, Mahajan S, Spatz E, Herrin J, Krumholz H. Trends in Prevalence, Treatment, and Relationship of Metabolic Syndrome and Individual Components by Race/Ethnicity, 1999-2018. JACC Advances 2025, 4: 101785. PMID: 40373521, PMCID: PMC12144450, DOI: 10.1016/j.jacadv.2025.101785.Peer-Reviewed Original ResearchLipid-lowering medication useRacial/ethnic disparitiesMedication useMetS prevalenceRacial/Ethnic DifferencesHispanic individualsAge-standardized prevalence estimatesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyBlack individualsPersistent racial/ethnic disparitiesFasting GlucoseNutrition Examination SurveyRelationship of metabolic syndromeMetabolic syndromePrescription drug useNationally representative dataExamination SurveyMetS componentsWaist circumferenceEligible individualsTreatment gapRacial/ethnic subgroupsU.S. adultsPrevalence estimatesDepression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D’Onofrio G, Pilote L, Lichtman J. Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction. Biopsychosocial Science And Medicine 2025, 87: 129-137. PMID: 39909011, DOI: 10.1097/psy.0000000000001363.Peer-Reviewed Original ResearchConceptsLow social supportCardiac-specific quality of lifeNatural direct effectSocial supportMonths post-AMIQuality of lifeAcute myocardial infarctionMarital stressComprehensive secondary preventive strategySignificant depressive symptomsPost-AMISecondary prevention strategiesYoung adultsMyocardial infarctionSociodemographic factorsDepressive symptomsAMI survivorsCovariate adjustmentPrevention strategiesSelf-ReportContinuous scoresQoLBaseline QOLCategorical depressionDepressionIsolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports
Rashedi S, Bejjani A, Hunsaker A, Aghayev A, Khairani C, McGonagle B, Lo Y, Mahajan S, Caraballo C, Jimenez J, Krishnathasan D, Zarghami M, Monreal M, Barco S, Secemsky E, Klok F, Muriel A, Hussain M, Appah-Sampong A, Rahaghi F, Sadeghipour P, Lin Z, Mojibian H, Aneja S, Konstantinides S, Goldhaber S, Wang L, Zhou L, Jimenez D, Krumholz H, Piazza G, Bikdeli B, Investigators T. Isolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports. Thrombosis Research 2025, 247: 109271. PMID: 39862754, DOI: 10.1016/j.thromres.2025.109271.Peer-Reviewed Original ResearchInternational Classification of Diseases (ICD)-10 codesICD-10International ClassificationPositive predictive valueDischarge diagnosisAccuracy of ICD-10Radiology reportsPrincipal discharge diagnosisSecondary discharge diagnosisIsolated subsegmental pulmonary embolismMedical records of adult patientsHealth systemRecords of adult patientsPredictive valueBlinded re-evaluationExpert radiologistsSubsegmental pulmonary embolismQuality improvementMedical recordsChart reviewPresence of PEProximal PEPulmonary embolismAdult patientsImaging ReportingSex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI
Park D, Mahajan S, Fishman E, Ambrosini A, Acero L, Hu J, Campbell G, Babapour G, Kelsey M, Douglas P, Gupta A, Frampton J, Nanna M. Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI. JACC Advances 2025, 4: 101543. PMID: 39886301, PMCID: PMC11780104, DOI: 10.1016/j.jacadv.2024.101543.Peer-Reviewed Original ResearchMonths of DAPTDuration of dual antiplatelet therapyNet adverse clinical eventsDuration of DAPTRandomized Controlled TrialsPercutaneous coronary interventionShorter duration of dual antiplatelet therapyRisk of bleedingBleeding riskLow risk of bleedingSex-based differencesAssociated with lower riskAdverse clinical eventsDual antiplatelet therapyAdverse cardiovascular eventsNetwork Meta-AnalysisWeb of Science databasesAntiplatelet therapyClinical impactCardiovascular eventsClinical eventsSystematic reviewSignificant sex-based differencesControlled TrialsCoronary intervention
2024
Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism
Bikdeli B, Khairani C, Bejjani A, Lo Y, Mahajan S, Caraballo C, Jimenez J, Krishnathasan D, Zarghami M, Rashedi S, Jimenez D, Barco S, Secemsky E, Klok F, Hunsaker A, Aghayev A, Muriel A, Hussain M, Appah-Sampong A, Lu Y, Lin Z, Mojibian H, Aneja S, Khera R, Konstantinides S, Goldhaber S, Wang L, Zhou L, Monreal M, Piazza G, Krumholz H, Investigators P. Validating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism. Journal Of Thrombosis And Haemostasis 2024, 23: 556-564. PMID: 39505153, PMCID: PMC12945443, DOI: 10.1016/j.jtha.2024.10.013.Peer-Reviewed Original ResearchDischarge codesInternational ClassificationICD-10Yale New Haven Health SystemPositive predictive valueMass General Brigham hospitalsAccuracy of ICD-10ICD-10 codesPulmonary embolismHealth systemImage codingElectronic databasesF1 scorePre-specified protocolExcellent positive predictive valueIndependent physiciansHighest F1 scoreIdentification of pulmonary embolismAcute pulmonary embolismSecondary codePE codesScoresIdentified PERevised algorithmGender disparities in utilization of statins for low density lipoprotein management across the spectrum of atherosclerotic cardiovascular disease: Insights from the houston methodist cardiovascular disease learning health system registry
Shahid I, Satish P, Gullapelli R, Nicholas J, Javed Z, Avenatti E, Bose B, Mahajan S, Roy T, Sharma G, Rodriguez F, Andrieni J, Jones S, Al-Kindi S, Cainzos-Achirica M, Nasir K. Gender disparities in utilization of statins for low density lipoprotein management across the spectrum of atherosclerotic cardiovascular disease: Insights from the houston methodist cardiovascular disease learning health system registry. American Journal Of Preventive Cardiology 2024, 19: 100722. PMID: 39281350, PMCID: PMC11402022, DOI: 10.1016/j.ajpc.2024.100722.Peer-Reviewed Original ResearchHigh-intensity statinsRacial/ethnic subgroupsSystem registryStatin utilizationLDL-CHigh-intensity statin useGender disparitiesSocioeconomic risk factorsLDL-C managementUS healthcare systemMultivariate logistic regression analysisLDL-C goalsLDL-C <Utilization of statinsAtherosclerotic cardiovascular diseaseLogistic regression analysisSocioeconomic subgroupsHealthcare systemStatin uptakeStatin useAdult patientsLipid managementLipoprotein managementStatinsSignificant gender disparityOPTIMIZING PHENOTYPING ALGORITHMS FOR IDENTIFYING PULMONARY EMBOLISM IN ELECTRONIC DATABASES: THE MULTICENTER PE-EHR+ STUDY
Bikdeli B, Bejjani A, Lo Y, Khairani C, Mahajan S, Secemsky E, Jimenez J, Aghayev A, Hunsaker A, Wang L, Hussain M, Appah-Sampong A, Mojibian H, Lin Z, Aneja S, Barco S, Klok F, Konstantinides S, Zhou L, Monreal M, Jimenez D, Piazza G, Krumholz H. OPTIMIZING PHENOTYPING ALGORITHMS FOR IDENTIFYING PULMONARY EMBOLISM IN ELECTRONIC DATABASES: THE MULTICENTER PE-EHR+ STUDY. Journal Of The American College Of Cardiology 2024, 83: 2108. DOI: 10.1016/s0735-1097(24)04098-1.Peer-Reviewed Original ResearchAssociation of marital/partner status with hospital readmission among young adults with acute myocardial infarction.
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D'Onofrio G, Pilote L, Lichtman J. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction. PLOS ONE 2024, 19: e0287949. PMID: 38277368, PMCID: PMC10817183, DOI: 10.1371/journal.pone.0287949.Peer-Reviewed Original ResearchConceptsMarital/partner statusPsychosocial factorsAcute myocardial infarctionYoung adultsHospital dischargeYear of hospital dischargeYoung acute myocardial infarctionAssociated with 1.3-foldCohort of young adultsLong-term readmissionCox proportional hazards modelsStatus interactionSimilar-aged menMyocardial infarctionProportional hazards modelUnpartnered statusPatient interviewsPhysician panelCardiovascular healthHospital readmissionSocioeconomic factorsAMI survivorsSequential adjustmentCardiac readmissionMultiple imputation
Academic Achievements & Community Involvement
News
News
- August 14, 2024
Welcome New Staff, Faculty, Fellows, Postgrads & Postdocs (August 2024)
- March 05, 2023
Enhancing Treatment for Persistent Hypertension: Unleashing the Power of Actionable Taxonomy from EHR Data for Precision Medicine
- January 18, 2023
Inpatient blood draws are often performed during sleep hours, Yale study finds
- December 18, 2022
Yale Insights in Cardiovascular Medicine: 2022