Xing Feng
Associate Research ScientistAbout
Research
Publications
2025
Spatiotemporal dynamics of fetal liver hematopoietic niches
Peixoto M, Soares-da-Silva F, Bonnet V, Zhou Y, Ronteix G, Santos R, Mailhe M, Nogueira G, Feng X, Pereira J, Azzoni E, Anselmi G, de Bruijn M, Perkins A, Baroud C, Pinto-do-Ó P, Cumano A. Spatiotemporal dynamics of fetal liver hematopoietic niches. Journal Of Experimental Medicine 2025, 222: e20240592. PMID: 39775824, PMCID: PMC11706214, DOI: 10.1084/jem.20240592.Peer-Reviewed Original ResearchConceptsFetal liverSource of hematopoietic growth factorsStromal cellsNon-hematopoietic stromal cellsHematopoietic growth factorsCytokine production patternsStromal cell populationsNeighboring stromal cellsEmbryonic hematopoietic cellsFetal hematopoiesisComplex cellular interactionsHematopoietic progenitorsHematopoietic cellsGrowth factorCell populationsFL developmentCellular interactionsCellsDevelopmental changesSignaling networks
2023
Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression
Zhang H, Chen G, Feng X, Song H, Meng L, Fu Y, Yang J, Fan Z, Ding Y, Du Z, Wang J, Yang L, Zhang J, Sun L, Liu Z, Zhang Z, Li Q, Fan X. Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression. EMBO Molecular Medicine 2023, 15: emmm202215924. PMID: 36947051, PMCID: PMC10165360, DOI: 10.15252/emmm.202215924.Peer-Reviewed Original ResearchConceptsMyeloid-derived suppressor cellsImmune microenvironmentReduces CD8<sup>+</sup> T cell infiltrationIntratumoral myeloid-derived suppressor cellsCD8<sup>+</sup> T cell infiltrationAnti-PD-L1Orthotopically implanted tumorsT cell infiltrationHepa1-6 cellsCapacity of HCC cellsInvasive capacity of HCC cellsSuppressor cellsLung metastasesPoor prognosisC57BL/6J miceHepatocellular carcinoma progressionImmunosuppressive effectsCarcinoma progressionTNFA locusNF-kBHCCHCC cellsFunctional lossTNFAHCC progression
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