Jonathan Weerakkody, PhD
Postdoctoral AssociateAbout
Research
Publications
2026
A novel biomimetic opto-electronic nose combining cross-reactive peptides with selective phage display peptides for enhanced performance
Escobar V, Brenet S, Hurot C, El Kazzy M, Weerakkody J, Mathey R, Scaramozzino N, Buhot A, Hou Y. A novel biomimetic opto-electronic nose combining cross-reactive peptides with selective phage display peptides for enhanced performance. Biosensors And Bioelectronics 2026, 302: 118551. PMID: 41747379, DOI: 10.1016/j.bios.2026.118551.Peer-Reviewed Original Research
2024
Study and optimization of the selectivity of an odorant binding protein-based bioelectronic nose
El Kazzy M, Lalis M, Hurot C, Weerakkody J, Mathey R, Saint-Pierre C, Buhot A, Livache T, Topin J, Moitrier L, Belloir C, Briand L, Hou Y. Study and optimization of the selectivity of an odorant binding protein-based bioelectronic nose. Biosensors And Bioelectronics 2024, 268: 116879. PMID: 39504883, DOI: 10.1016/j.bios.2024.116879.Peer-Reviewed Original ResearchConceptsvolatile organic compoundsgas phasemolecular dynamics simulationsdevelopment of biosensorsdynamics simulationsbinding pocketbiosensororganic compoundsfundamental studiesabsence of cysteineOdorant-binding proteinscysteine residuesimmobilizationrelative humidityselectioncompoundscysteinegasphaseamino acidsPhotosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations (Adv. Funct. Mater. 34/2024)
Weerakkody J, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides T, Gunasekara R, Ramakrishnan S. Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations (Adv. Funct. Mater. 34/2024). Advanced Functional Materials 2024, 34 DOI: 10.1002/adfm.202470191.Peer-Reviewed Original Researchvesicle biogenesisextracellular vesicle subpopulationslipid nanoprobesvesicle subpopulationsnative extracellular vesiclesvesicle populationsseparate vesiclespurity isolationextracellular vesiclesvesiclescellular originhydrophobic interactionsbiogenesissize variabilitysubpopulationsisolatesextracellularCNS cell-derived exosome signatures as blood-based biomarkers of neurodegenerative diseases
Park, C., Weerakkody, J. S., Schneider, R., Miao, S., & Pitt, D. (2024). CNS cell-derived exosome signatures as blood-based biomarkers of neurodegenerative diseases. Frontiers in Neuroscience, 18, 1426700.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCNS cell-derived exosome signatures as blood-based biomarkers of neurodegenerative diseases
Park C, Weerakkody J, Schneider R, Miao S, Pitt D. CNS cell-derived exosome signatures as blood-based biomarkers of neurodegenerative diseases. Frontiers In Neuroscience 2024, 18: 1426700. PMID: 38966760, PMCID: PMC11222337, DOI: 10.3389/fnins.2024.1426700.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementsneurodegenerative diseasessubtype of extracellular vesiclesdisease-related processesdisease-associated changescentral nervous systemblood-based proteinsbiomarkers of neurodegenerative diseasesblood-brain barriercell typesexosome populationmolecular cargoextracellular vesiclescell of originRNA biomarkersexosome isolationtranslation to clinical usecell-derived exosomeslack of standardized methodologymolecular contentexosomesblood-based biomarkersperipheral bloodcellsexosome signaturemolecular biomarkersPhotosensitive Nanoprobes for Rapid High Purity Isolation and Size-Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations
Weerakkody, Jonathan S., Tiffany Tseng, Mackenzie Topper, Sikha Thoduvayil, Abhijith Radhakrishnan, Frederic Pincet, Themis R. Kyriakides, Roshan W. Gunasekara, and Sathish Ramakrishnan. "Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations." Advanced Functional Materials (2024): 2400390.Peer-Reviewed Original ResearchPhotosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations
Weerakkody J, Tseng T, Topper M, Thoduvayil S, Radhakrishnan A, Pincet F, Kyriakides T, Gunasekara R, Ramakrishnan S. Photosensitive Nanoprobes for Rapid High Purity Isolation and Size‐Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations. Advanced Functional Materials 2024, 34: 2400390. PMID: 39372670, PMCID: PMC11452007, DOI: 10.1002/adfm.202400390.Peer-Reviewed Original Researchextracellular vesicle subpopulationsvesicle subpopulationsisolation of vesiclespurity extracellular vesiclesrelease of vesiclesanalysis of nucleic acidsnear-native formlarge-scale isolationlipid nanoprobesdownstream analysispurity isolationefficient isolationvesiclessynthetic vesiclesnucleic acidsextracellular vesiclesisolation methodisolatesbiomarker discoveryexposure to lightsubpopulationsenrichmentproteincomplex biological mediacleavage
2023
Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy
Thoduvayil S, Weerakkody J, Sundaram R, Topper M, Bera M, Coleman J, Li X, Mariappan M, Ramakrishnan S. Rapid Quantification of First and Second Phase Insulin Secretion Dynamics using an In vitro Platform for Improving Insulin Therapy. Cell Calcium 2023, 113: 102766. PMID: 37295201, PMCID: PMC10450995, DOI: 10.1016/j.ceca.2023.102766.Peer-Reviewed Original ResearchConceptscellular pathwayssecretion dynamicssmall molecule screeningluciferase reporter systeminsulin secretion dynamicshigh-throughput compoundinsulin secretionhigh-throughput quantificationreporter systemgenetic studieslive cellsdistinct rolesinsulin therapyglucose-stimulated insulin secretionsmall moleculeseffective insulin therapypathwaysecretion
2022
Native Planar Asymmetric Suspended Membrane for Single‐Molecule Investigations: Plasma Membrane on a Chip (Small 51/2022)
Sundaram R, Bera M, Coleman J, Weerakkody J, Krishnakumar S, Ramakrishnan S. Native Planar Asymmetric Suspended Membrane for Single‐Molecule Investigations: Plasma Membrane on a Chip (Small 51/2022). Small 2022, 18 DOI: 10.1002/smll.202270277.Peer-Reviewed Original Researchgiant plasma membrane vesiclestotal internal reflection fluorescence microscopymembrane protein assemblyplasma membrane vesiclesreflection fluorescence microscopydifferent cell typessingle-molecule investigationsprotein functionprotein assembliesinner leafletplasma membranemembrane vesiclescell typeslipid architecturefluorescence microscopylipid membranesmolecule investigationsmembranesilicon-based platformvesiclesassemblycellsbilayersleafletsNative Planar Asymmetric Suspended Membrane for Single‐Molecule Investigations: Plasma Membrane on a Chip
Sundaram R, Bera M, Coleman J, Weerakkody J, Krishnakumar S, Ramakrishnan S. Native Planar Asymmetric Suspended Membrane for Single‐Molecule Investigations: Plasma Membrane on a Chip. Small 2022, 18: e2205567. PMID: 36328714, DOI: 10.1002/smll.202205567.Peer-Reviewed Original ResearchConceptsplasma membraneprotein assembliesnative plasma membrane vesiclestotal internal reflection fluorescence microscopysingle-molecule levelsingle-molecule investigationscellular plasma membraneplasma membrane vesiclessingle-molecule precisionreflection fluorescence microscopyknowledge of lipidprotein complexesprotein architecturecell signalingmovement of moleculesprotein orientationlipid membranesbiological processescellular membranesmembrane vesiclesmicroarray platformfluorescence investigationslipid domainsfluorescence microscopymembrane
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