Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsZubin Bhagwagar, MBBS, MD, FRCPsych, DPhil
About
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Biography
Zubin is a physician scientist with 30 years of experience in academia and the pharmaceutical industry. His area of expertise includes clinical development and business development in neuroscience and rare diseases. He is the Vice President of External Innovation at Intra Cellular Therapies, a Johnson and Johnson company. Previous positions include Chief Medical Officer at Certego Therapeutics, SVP R&D at Rallybio (a rare disease focussed biotech which went public in 2021), and Vice President and Head of External Innovation at Alexion Pharmaceuticals, where he also led the Strategic Evaluation team in Business Development. He previously held positions of increasing responsibility at Bristol-Myers Squibb, where he worked in multiple therapeutic areas including neuroscience and clinical pharmacology and was in academia prior to BMS.
Zubin received his medical degree and completed his psychiatry residency at Delhi University. He subsequently completed another residency in psychiatry at the University of Oxford, where he was awarded a DPhil (Ph.D.) in neuroimaging and neurobiology. He is a Fellow of the Royal College of Psychiatrists (UK), the American College of Neuropsychopharmacology, and the American Psychiatric Association and has authored more than 85 papers in neuroscience/psychiatry. He has been on the faculty of the Department of Psychiatry at Yale University School of Medicine since 2005, where he is an Adjunct Associate Professor.
Departments & Organizations
Education & Training
- DPhil
- University of Oxford (2004)
- Medical Research Council Clinical Training Fellow
- Medical School, University Of Oxford (2001)
- Clinical Research Fellow
- Institute of Psychiatry, King's College London (1999)
- Resident
- University of Oxford (1998)
- MD
- Maulana Azad Medical College (1994)
- Resident
- University of Delhi (1994)
- MBBS
- Maulana Azad Medical College (1989)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-1101-768X
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
John Krystal, MD
David Matuskey, MD
Jean-Dominique Gallezot, PhD
Michael Bloch, MD, MS
Nabeel Nabulsi, PhD
Peter Morgan, MD, PhD
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neuroimaging
Publications
2022
An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study
Geisen C, Kjaer M, Fleck E, Skogen B, Armstrong R, Behrens F, Bhagwagar Z, Braeuninger S, Mortberg A, Olsen K, Gastón Schäfer S, Walter C, Seifried E, Wikman A, Kjeldsen-Kragh J, Koehm M. An HPA-1a–positive platelet–depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo–controlled, single-center, phase 1/2 proof-of-concept study. Journal Of Thrombosis And Haemostasis 2022, 21: 838-849. PMID: 36696185, DOI: 10.1016/j.jtha.2022.11.041.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFetal/Neonatal Alloimmune ThrombocytopeniaNeonatal alloimmune thrombocytopeniaHPA-1aAlloimmune thrombocytopeniaHuman platelet antigen 1aTreatment-emergent adverse eventsPlacebo 1 hourHPA-1a antibodiesFNAIT casesHyperimmune IgGPrimary endpointAdverse eventsFetus/Healthy menSingle doseAntigen 1aHLA-A2Concept studyCohort 1PlaceboFlow cytometryThrombocytopeniaPlateletsAdministrationWeeks
2021
Benefit–risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations
Kleykamp BA, Dworkin RH, Turk DC, Bhagwagar Z, Cowan P, Eccleston C, Ellenberg SS, Evans SR, Farrar JT, Freeman RL, Garrison LP, Gewandter JS, Goli V, Iyengar S, Jadad AR, Jensen MP, Junor R, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, McDermott MP, Mease PJ, O'Connor AB, Patel KV, Raja SN, Rowbotham MC, Sampaio C, Singh JA, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Benefit–risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain 2021, 163: 1006-1018. PMID: 34510135, PMCID: PMC8904641, DOI: 10.1097/j.pain.0000000000002475.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsRandomized clinical trialsClinical trialsBenefit-risk assessmentChronic painChronic pain clinical trialsPain clinical trialsDifferent patient subpopulationsChronic pain treatmentKey professional organizationsIMMPACT recommendationsPain treatmentPain assessmentPatient subpopulationsIndividual patientsConsensus meetingSpecific treatmentClinical meaningfulnessRCT resultsTrialsTreatment group levelPainRisk outcomesTreatmentAssessment toolPrimary recommendation
2020
Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations.
Smith SM, Dworkin RH, Turk DC, McDermott MP, Eccleston C, Farrar JT, Rowbotham MC, Bhagwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor R, Kamp C, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, Mease PJ, O'Connor AB, Patel KV, Raja SN, Sampaio C, Schoenfeld D, Singh J, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD. Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain 2020, 161: 2446-2461. PMID: 32520773, PMCID: PMC7572524, DOI: 10.1097/j.pain.0000000000001952.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsInverse changes in raphe and cortical 5‐HT1B receptor availability after acute tryptophan depletion in healthy human subjects
Baldassarri SR, Park E, Finnema SJ, Planeta B, Nabulsi N, Najafzadeh S, Ropchan J, Huang Y, Hannestad J, Maloney K, Bhagwagar Z, Carson RE. Inverse changes in raphe and cortical 5‐HT1B receptor availability after acute tryptophan depletion in healthy human subjects. Synapse 2020, 74: e22159-e22159. PMID: 32324935, PMCID: PMC7426238, DOI: 10.1002/syn.22159.Peer-Reviewed Original ResearchCitationsAltmetric
2019
Lithium for acute mania
Bhagwagar Z, Goodwin G, Geddes J. Lithium for acute mania. Cochrane Database Of Systematic Reviews 2019, 2019 PMCID: PMC6524414, DOI: 10.1002/14651858.cd004048.pub3.Peer-Reviewed Original Research
2017
A Systematic Review and Pooled Analysis of Select Safety Parameters Among Normal Healthy Volunteers Taking Placebo in Phase 1 Clinical Trials
Young TC, Srinivasan S, Vetter ML, Sethuraman V, Bhagwagar Z, Zwirtes R, Narasimhan P, Chuang T, Smyth BJ. A Systematic Review and Pooled Analysis of Select Safety Parameters Among Normal Healthy Volunteers Taking Placebo in Phase 1 Clinical Trials. The Journal Of Clinical Pharmacology 2017, 57: 1079-1087. PMID: 28510323, PMCID: PMC5573961, DOI: 10.1002/jcph.913.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsAdverse eventsPooled analysisClinical trialsAlanine aminotransferaseSystematic reviewMultiple ascending dose studyHigher diastolic blood pressurePhase 1 clinical trialEarly phase clinical trialsAscending dose studyDiastolic blood pressurePhase 1 trialCreatine kinase elevationNormal healthy volunteersPhase clinical trialsFuture study designsBlood pressureDose studySafety signalsHealthy volunteersVital signsStudy designLaboratory evaluationTrialsPlacebo
2016
OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding
Pittenger C, Adams TG, Gallezot JD, Crowley MJ, Nabulsi N, Ropchan J, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. Journal Of Affective Disorders 2016, 196: 87-96. PMID: 26919057, PMCID: PMC4808438, DOI: 10.1016/j.jad.2016.02.021.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPrepulse inhibitionObsessive-compulsive disorderReceptor availabilitySensorimotor gatingOCD patientsImpaired sensorimotor gatingOCD-like behaviorNon-depressed OCD patientsPositron emission tomographyBasal gangliaSerotonergic regulationHealthy controlsSerotonin systemPositive correlationWidespread positive correlationsDiagnostic groupsCortical regionsEmission tomographyOrbitofrontal cortexPatientsReceptor bindingOCD diagnosisSignificant correlationSignificant main effectImportant alterations
2015
Assessment of the Efficacy and Safety of BMS-820836 in Patients With Treatment-Resistant Major Depression
Bhagwagar Z, Torbeyns A, Hennicken D, Zheng M, Dunlop BW, Mathew SJ, Khan A, Weisler R, Nelson C, Shelton R, Thase ME, Lane R. Assessment of the Efficacy and Safety of BMS-820836 in Patients With Treatment-Resistant Major Depression. Journal Of Clinical Psychopharmacology 2015, 35: 454-459. PMID: 25961781, DOI: 10.1097/jcp.0000000000000335.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBMS-820836MADRS total scoreTreatment-resistant depressionMean changeAntidepressant treatmentTotal scoreMontgomery-Åsberg Depression Rating Scale (MADRS) total scoreTreatment-resistant major depressionEnd pointStandard antidepressant treatmentPrimary end pointDouble-blind studyScale total scoreAdequate trialAntidepressant therapyAdverse eventsFlexible doseContinuation groupInadequate responseMajor depressionInadequate respondersPhase 2bPatientsPhase treatmentWeeksComparison of different QT interval correction methods for heart rate and QT beat‐to‐beat method in a thorough QT study of triple monoamine reuptake inhibitor BMS‐820836
Zheng M, Burt D, Chan W, Hawthorne D, Gasior M, Bhagwagar Z, Keswani S, AbuTarif M, Bertz R. Comparison of different QT interval correction methods for heart rate and QT beat‐to‐beat method in a thorough QT study of triple monoamine reuptake inhibitor BMS‐820836. The Journal Of Clinical Pharmacology 2015, 55: 1137-1146. PMID: 25904041, DOI: 10.1002/jcph.528.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsThorough QT studyBMS-820836QT studyQT intervalHeart rateFree plasma concentrationsHeart rate increaseHERG IC50Parallel groupPlasma concentrationsHealthy subjectsQT interval correction methodsEnd pointStudy designLower likelihoodQTcIPearson correlation coefficientQTcFMoxifloxacinSubjectsWide marginQTUptitrationΔΔQTcF.ΔΔQTcI
2014
Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943
Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z. Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943. European Journal Of Nuclear Medicine And Molecular Imaging 2014, 42: 468-477. PMID: 25427881, DOI: 10.1007/s00259-014-2958-5.Peer-Reviewed Original ResearchCitations