Yuyin Jiang
Coordinator 4, Research SupportAbout
Research
Publications
2026
HOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers
Jiang Y, Cheng S, Zhang C, Jin X, Li L, Shin H, Alrefai A, Luo A, Xu Y, Kim I, Mu P. HOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers. Cancer Letters 2026, 648: 218465. PMID: 41912135, DOI: 10.1016/j.canlet.2026.218465.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaLineage plasticityPharmacologic inhibition of HDAC3RNA-seqPharmacological inhibitionBinding partnersCancer cellsProstate cancer modelSingle-cell RNA-seqRNA-seq samplesActive enhancer marksTargetable driversMulti-omics dataDifferential expression analysisInhibition of HDAC3Prostate cancerTherapy resistanceCause of deathMyeloid leukemiaTargeted therapyCancer modelsTumor progressionLipid nanoparticlesLung cancerCancer subtypes
2024
ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
Xu Y, Yang Y, Wang Z, Sjostrom M, Jiang Y, Tang Y, Cheng S, Deng S, Wang C, Gonzalez J, Johnson N, Li X, Li X, Metang L, Mukherji A, Xu Q, Tirado C, Wainwright G, Yu X, Barnes S, Hofstad M, Chen Y, Zhu H, Hanker A, Raj G, Zhu G, He H, Wang Z, Arteaga C, Liang H, Feng F, Wang Y, Wang T, Mu P. ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Cancer Discovery 2024, 14: 1496-1521. PMID: 38591846, PMCID: PMC11285331, DOI: 10.1158/2159-8290.cd-23-0539.Peer-Reviewed Original ResearchConceptsLineage plasticityTherapy resistanceProstate cancerCancer cellsAndrogen receptorResistance to AR-targeted therapiesLuminal lineageAR-targeted therapiesOvercome therapy resistanceTransition of cancer cellsEpigenetic regulatory machineryBona fide coactivatorTherapy responseAR signalingEpigenetic rewiringDrug resistanceTherapeutic strategiesEpigenetic reprogrammingProstateTherapyCancerPhenotypic plasticityRegulatory machineryAndrogenTranscriptional programs
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