Longjun Li
Postdoctoral AssociateDownloadHi-Res Photo
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Postdoctoral Associate
Departments & Organizations
- Mu Lab
Research
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Overview
Medical Research Interests
Biomarkers, Tumor; Cell Death
Public Health Interests
Biomarkers; Immunology
ORCID
0009-0005-4797-9353Mu Lab, Urology
Our lab is dedicated to uncovering the molecular mechanisms that drive resistance to targeted and immune therapies in prostate and other cancers.
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Longjun Li's published research.
Publications Timeline
A big-picture view of Longjun Li's research output by year.
Anfeng Luo
Isaac Y. Kim, MD, PhD, MBA
Ping Mu, PhD
Siyuan Cheng
Yaru Xu
Yuyin Jiang
11Publications
389Citations
Publications
2026
HOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers
Jiang Y, Cheng S, Zhang C, Jin X, Li L, Shin H, Alrefai A, Luo A, Xu Y, Kim I, Mu P. HOX code–based stratification reveals RUNX1T1–HDAC reprogramming as a targetable driver of lineage plasticity across cancers. Cancer Letters 2026, 648: 218465. PMID: 41912135, DOI: 10.1016/j.canlet.2026.218465.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThis study investigates how HOX gene expression patterns identify therapy-resistant cancer subtypes and demonstrates RUNX1T1-HDAC3 inhibition as a potential treatment strategy for aggressive cancers.
2024
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer
Li L, Xu T, Qi X. Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer. Immunological Reviews 2024, 329: e13417. PMID: 39523732, DOI: 10.1111/imr.13417.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsCorrection: FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Yao S, Li L, Sun X, Hua J, Zhang K, Hao L, Liu L, Shi D, Zhou H. Correction: FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation. Journal Of Neuroimmune Pharmacology 2024, 19: 42. PMID: 39105974, DOI: 10.1007/s11481-024-10137-7.Commentaries, Editorials and LettersNCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance
Li L, Mao R, Yuan S, Xie Q, Meng J, Gu Y, Tan S, Xu X, Gao C, Liu H, Ma C, Man S, Meng X, Xu T, Qi X. NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance. Nature Communications 2024, 15: 5170. PMID: 38886341, PMCID: PMC11183137, DOI: 10.1038/s41467-024-49549-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsCARD Signaling Adaptor ProteinsCD8-Positive T-LymphocytesCell Line, TumorColorectal NeoplasmsDisease ProgressionFemaleHumansImmunologic SurveillanceInflammasomesInterleukin-18Killer Cells, NaturalMaleMiceMice, Inbred C57BLMice, KnockoutNADPH OxidasesNLR Family, Pyrin Domain-Containing 3 ProteinPhosphorylationReactive Oxygen Species
2021
Intracellular C3 prevents hepatic steatosis by promoting autophagy and very‐low‐density lipoprotein secretion
Li Y, Sha Y, Wang H, He L, Li L, Wen S, Sheng L, Hu W, Zhou H. Intracellular C3 prevents hepatic steatosis by promoting autophagy and very‐low‐density lipoprotein secretion. The FASEB Journal 2021, 35: e22037. PMID: 34762761, DOI: 10.1096/fj.202100856r.Peer-Reviewed Original ResearchCitationsAltmetricMicroscopic Detection of ASC Inflammasomes in Bone Marrow Derived Macrophages Post Stimulation.
Li L, Mao R, Qi X. Microscopic Detection of ASC Inflammasomes in Bone Marrow Derived Macrophages Post Stimulation. Bio-protocol 2021, 11: e4151. PMID: 34604456, PMCID: PMC8443463, DOI: 10.21769/bioprotoc.4151.Peer-Reviewed Original ResearchCitationsIntravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis
Wang H, Li L, Li Y, Li Y, Sha Y, Wen S, You Q, Liu L, Shi M, Zhou H. Intravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis. Theranostics 2021, 11: 2149-2169. PMID: 33500717, PMCID: PMC7797696, DOI: 10.7150/thno.51369.Peer-Reviewed Original ResearchCitationsAltmetric
2020
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection
Guo Y, Li L, Xu T, Guo X, Wang C, Li Y, Yang Y, Yang D, Sun B, Zhao X, Shao G, Qi X. HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. Journal Of Clinical Investigation 2020, 130: 6301-6316. PMID: 33104527, PMCID: PMC7685759, DOI: 10.1172/jci138234.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBacteriaBacterial InfectionsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCaspase 1DNA-Binding ProteinsHEK293 CellsHumansInflammasomesInterleukin-1betaMacrophagesMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinTumor Suppressor ProteinsUbiquitin-Protein Ligases
2019
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition
Li L, Wang H, Zhang J, Sha Y, Wu F, Wen S, He L, Sheng L, You Q, Shi M, Liu L, Zhou H. SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition. Cell Death & Differentiation 2019, 27: 1924-1937. PMID: 31827236, PMCID: PMC7244772, DOI: 10.1038/s41418-019-0471-x.Peer-Reviewed Original ResearchCitationsAltmetricFTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Yao S, Li L, Sun X, Hua J, Zhang K, Hao L, Liu L, Shi D, Zhou H. FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation. Journal Of Neuroimmune Pharmacology 2019, 14: 478-492. PMID: 31069623, DOI: 10.1007/s11481-019-09843-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsAntiparkinson AgentsApoptosisCell LineCorpus StriatumCytokinesDopaminergic NeuronsDrug Evaluation, PreclinicalExploratory BehaviorFingolimod HydrochlorideInflammasomesMaleMiceMice, Inbred C57BLMicrogliaMitochondriaMPTP PoisoningNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinParkinsonian DisordersPars CompactaReactive Oxygen SpeciesRotarod Performance TestSignal Transduction
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