Joseph D. Deak, PhD
Assistant Professor of PsychiatryCards
About
Research
Publications
2026
Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts
Javidnia S, Roe J, Karhunen V, Gill D, Bell S, Deak J, Levey D, Kember R, Kranzler H, Cronjé H, Burgess S, Gelernter J, Ebmeier K, Topiwala A. Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts. Alzheimer's & Dementia 2026, 22: e71418. PMID: 42170857, PMCID: PMC13240559, DOI: 10.1002/alz.71418.Peer-Reviewed Original ResearchAgedBrainCohort StudiesDementiaEuropean PeopleFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleMendelian Randomization AnalysisMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, muRisk FactorsWhite PeopleFrom Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics
Davies H, Ryan N, Reed K, Berthold N, Maina J, McNulty R, ter Kuile A, Ubah O, Trujillo-ChiVacuan E, Schulte E, Yang J, de Wit M, Bruxel E, Deak J, Koromina M, Sollie T, Braun A, Bulik C, Lewis C, Dick D, Guintivano J, Edenberg H. From Genomes to Conversations: Outreach and Engagement in Psychiatric Genetics. Behavior Genetics 2026, 1-9. PMID: 41642423, DOI: 10.1007/s10519-025-10246-w.Peer-Reviewed Original Research
2025
Multi-ancestry investigation of the genomics of erectile dysfunction
Bright U, Chen Y, Deak J, Zhou H, Levey D, Gelernter J. Multi-ancestry investigation of the genomics of erectile dysfunction. Nature Communications 2025, 16: 11602. PMID: 41285899, PMCID: PMC12749275, DOI: 10.1038/s41467-025-66723-7.Peer-Reviewed Original ResearchEnvironmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries
Na P, Deak J, Levey D, Kember R, Kranzler H, Pietrzak R, Gelernter J. Environmental, Psychiatric, and Genetic Predictors of Alcohol Use Disorder Criterion Count: Analyses of African and European Ancestries. American Journal Of Psychiatry 2025, 182: 1007-1015. PMID: 40988466, PMCID: PMC13059437, DOI: 10.1176/appi.ajp.20240893.Peer-Reviewed Original ResearchAlcohol use and risk of dementia in diverse populations: evidence from cohort, case–control and Mendelian randomisation approaches
Topiwala A, Levey D, Zhou H, Deak J, Adhikari K, Ebmeier K, Bell S, Burgess S, Nichols T, Program V, Gaziano J, Stein M, Gelernter J. Alcohol use and risk of dementia in diverse populations: evidence from cohort, case–control and Mendelian randomisation approaches. BMJ Evidence-Based Medicine 2025, 31: 13-22. PMID: 40987604, PMCID: PMC7618643, DOI: 10.1136/bmjebm-2025-113913.Peer-Reviewed Original ResearchGenetics of SSRI antidepressant use and relationship to psychiatric and medical traits
Levey D, Galimberti M, Deak J, Gupta P, Empke S, Adhikari K, Harrington K, Quaden R, Gaziano J, Program V, Stein M, Gelernter J. Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits. Human Genetics And Genomics Advances 2025, 7: 100500. PMID: 40903904, PMCID: PMC12494825, DOI: 10.1016/j.xhgg.2025.100500.Peer-Reviewed Original ResearchMulti-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Johnson E, Lai D, Balbona J, Miller A, Hatoum A, Deak J, Jennings M, Baranger D, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert S, Adhikari K, Docherty A, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries P, Korhonen T, Morrison C, Nunez Y, Palviainen T, Su M, Villela P, Wetherill L, Willoughby E, Zellers S, Bierut L, Buchwald J, Copeland W, Corley R, Friedman N, Foroud T, Gillespie N, Gizer I, Heath A, Hickie I, Kaprio J, Keller M, Lee J, Lind P, Madden P, Maes H, Martin N, McGue M, Medland S, Nelson E, Pearson J, Porjesz B, Stallings M, Vrieze S, Wilhelmson K, Kranzler H, Walters R, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg H, Gelernter J, Agrawal A. Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. Psychological Medicine 2025, 55: e234. PMID: 40831304, PMCID: PMC12360691, DOI: 10.1017/s0033291725100883.Peer-Reviewed Original ResearchA contextual genomic perspective on physical activity and its relationship to health, well being and illness
Galimberti M, Levey D, Deak J, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake N, Harrington K, Djousse L, Davis L, Gaziano J, Stein M, Gelernter J. A contextual genomic perspective on physical activity and its relationship to health, well being and illness. Nature Genetics 2025, 57: 1860-1871. PMID: 40691405, PMCID: PMC12339386, DOI: 10.1038/s41588-025-02260-9.Peer-Reviewed Original ResearchThe genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchEpigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses
Pathak G, Pietrzak R, Lacobelle A, Overstreet C, Wendt F, Deak J, Friligkou E, Nunez Y, Montalvo-Ortiz J, Levey D, Kranzler H, Gelernter J, Polimanti R. Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. Molecular Psychiatry 2025, 30: 4435-4443. PMID: 40247127, PMCID: PMC12343199, DOI: 10.1038/s41380-025-03031-y.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News & Links
News
- July 28, 2026
Yale Scientists Gain New Insight Into Genetic Architecture of Fibromyalgia
- December 02, 2025Source: Nature Communications
Multi-Ancestry Investigation of the Genomics of Erectile Dysfunction
- September 24, 2025Source: BMJ Evidence-Based Medicine
Alcohol Use and Risk of Dementia in Diverse Populations: Evidence from Cohort, Case–Control and Mendelian Randomisation Approaches
- September 24, 2025
New Study Reveals Genetic, Psychiatric, and Environmental Factors Contributing to Alcohol Use Disorder
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