Yanis Chemli, PhD
Postdoctoral AssociateAbout
Research
Publications
2025
In vivo 3D myocardial membrane potential mapping in humans using PET/MRI
Bijari F, Han P, Marin T, Lee W, Chemli Y, Gertsenshteyn I, Mounime I, Djebra Y, Chi D, Normandin M, Ma C, Fakhri G. In vivo 3D myocardial membrane potential mapping in humans using PET/MRI. EJNMMI Research 2025, 15: 93. PMID: 40715686, PMCID: PMC12297085, DOI: 10.1186/s13550-025-01287-7.Peer-Reviewed Original ResearchMembrane potentialExtracellular volume fraction measurementsExtracellular volume fraction mappingBolus-plus-infusion protocolT1 mapping sequencesVolume of distributionWritten Informed ConsentCardiac PET/MR imagingRigid image registrationHumans in vivoContrast agent injectionPET motion correctionFree breathingTracer volume of distributionImage registrationBolus injectionCardiac MRMitochondrial membrane potentialCardiac diseaseHealthy subjectsPET/MR imagingImaging studiesTreatment monitoringAgent injectionPET tracersQuantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240.
Xia Y, Dhaynaut M, Chemli Y, Lois C, Hanseeuw B, Thibault E, Groot C, Ossenkoppele R, Johnson K, El Fakhri G, Normandin M, Guehl N. Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240. Journal Of Nuclear Medicine 2025, 66: 1299-1306. PMID: 40533354, PMCID: PMC12320581, DOI: 10.2967/jnumed.125.270165.Peer-Reviewed Original Research3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy
Jee K, Bijari F, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kang J, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Levine R, Lehmann H, Fakhri G. 3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy. Radiotherapy And Oncology 2025, 206: s3543-s3544. DOI: 10.1016/s0167-8140(25)01927-9.Peer-Reviewed Original ResearchDual Prompting for Diverse Count-Level Pet Denoising
Liu X, Huang Y, Marin T, Vafay Eslahi S, Tiss A, Chemli Y, Johnson K, El Fakhri G, Ouyang J. Dual Prompting for Diverse Count-Level Pet Denoising. 2011 IEEE International Symposium On Biomedical Imaging: From Nano To Macro 2025, 00: 1-5. PMID: 40831530, PMCID: PMC12360122, DOI: 10.1109/isbi60581.2025.10980695.Peer-Reviewed Original ResearchPO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY
Kang J, Bijari F, Jee K, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Fakhri G, Levine R, Lehmann H. PO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY. Heart Rhythm 2025, 22: s484. DOI: 10.1016/j.hrthm.2025.03.1230.Peer-Reviewed Original ResearchFlexible and modular PET: Evaluating the potential of TOF‐DOI panel detectors
Razdevšek G, Fakhri G, Marin T, Dolenec R, Orehar M, Chemli Y, Gola A, Gascon D, Majewski S, Pestotnik R. Flexible and modular PET: Evaluating the potential of TOF‐DOI panel detectors. Medical Physics 2025, 52: 2845-2860. PMID: 40089973, PMCID: PMC12059530, DOI: 10.1002/mp.17741.Peer-Reviewed Original ResearchDepth of interactionLong axial field-of-viewTime-of-flightPanel detectorHigh-performance computing clusterDepth-of-interaction resolutionNoise equivalent count rateDepth-of-interaction capabilityDepth-of-interaction detectorsAxial field-of-viewImage qualityTime-of-flight (TOFDistortion-free imagesPositron emission tomography scannerLong axial fieldComputer clusterSpatial resolutionLSO crystalsImage reconstructionDetector materialCount rateGATE softwareContrast-to-noise ratioParallax errorMonte Carlo simulationsPET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction
Marin T, Belov V, Chemli Y, Ouyang J, Najmaoui Y, Fakhri G, Duvvuri S, Iredale P, Guehl N, Normandin M, Petibon Y. PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction. IEEE Transactions On Biomedical Engineering 2025, 72: 1057-1066. PMID: 39446540, PMCID: PMC11875991, DOI: 10.1109/tbme.2024.3486191.Peer-Reviewed Original ResearchCentral nervous systemReceptor occupancyLow-binding regionsPET scansSimulation resultsPreclinical in vivo experimentsDynamic PET scansPairs of baselineEstimation of receptor occupancyEstimation frameworkPET neuroimagingReconstruction frameworkModulating drugsTime activity curvesParametric reconstructionDevelopment of drugs
2024
Integration of a continuously varying image-space PSF for a dual-panel ultra-high TOF-PET scanner
Chemli Y, Marin T, Orehar M, Dolenec R, Normandin M, Gascón D, Gola A, Grogg K, Pavón G, Razdevsek G, Pestotnik R, Fakhri G. Integration of a continuously varying image-space PSF for a dual-panel ultra-high TOF-PET scanner. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10656225.Peer-Reviewed Original ResearchGaussian mixture modelGaussian process regressionPoint spread functionAccurate image reconstructionMaximum likelihood estimation maximizationShift-variant convolutionsImage reconstructionMixture modelProcess regressionEstimation maximizationTime-of-flight (TOFPanel architectureSpread functionArchitectureParameter interpolationHigh resolution time-of-flight (TOFTOF-PET scannerBrain phantomFitting processPositron emission tomography scannerSimulated point sourcesConvolutionAlgorithmEffective diagnosisSize benefitsFlat Panel TOF-PET Detectors: a Simulation Study
Orehar M, Dolenec R, Fakhri G, Gascón D, Gola A, Korpar S, Križan P, Razdevšek G, Marin T, Chemli Y, Žontar D, Pestotnik R. Flat Panel TOF-PET Detectors: a Simulation Study. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10658250.Peer-Reviewed Original ResearchTime resolutionAngular coverageFlat-panel detectorScintillation materialsGATE softwareAxial coverageBiograph VisionPanel detectorTotal-body coverageClinical scannerImage reconstructionDetectorReconstructed imagesHomogeneous contrastCylindrical scannerImage qualityState-of-the-artScintillationHigh-performance computingScannerPhantomResolutionCore hoursPositron emission tomographyGateLong-Axial Field-Of-View Limited-Angle PET System with Ultra-High Time-Of-Flight and Depth-Of-Interaction
Marin T, Chemli Y, Razdevšek G, Zhuo Y, Orehar M, Najmaoui Y, Dolenec R, Gascon D, Gola A, Benlloch J, Alamo J, Barbera J, Fernandez-Tenllado J, Gomez S, Korpar S, Krizan P, Majewski S, Manera R, Mariscal-Castilla A, Mauricio J, Merzi S, Morera C, Pavon G, Pavon N, Penna M, Seljak A, Studen A, Zontar D, Pestotnik R, Fakhri G. Long-Axial Field-Of-View Limited-Angle PET System with Ultra-High Time-Of-Flight and Depth-Of-Interaction. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10658297.Peer-Reviewed Original ResearchDepth of interactionDepth-of-interaction resolutionTime-of-flightPET systemImage quality metricsTime-of-flight resolutionField-of-view scanningSacrificing image qualityQuality metricsSilicon photomultipliersDetector panelPET instrumentationImage qualityResolution systemAngle geometryGeometric correctionReduce costsPerformancePhotomultiplierSystemResolutionMetricsElectron