Yadong Wang
Associate Research Scientist in GeneticsCards
About
Research
Publications
2025
Caffeine-catalyzed synthesis of photopolymers for digital light processing
Ma W, D'Amato A, Wang Y. Caffeine-catalyzed synthesis of photopolymers for digital light processing. Green Chemistry 2025, 27: 8319-8332. DOI: 10.1039/d5gc00177c.Peer-Reviewed Original ResearchCis-5-norbornene-endo-2,3-dicarboxylic anhydrideExcellent elastic recoveryGreen chemistry principlesChain endPhoto-additionPropylene oxideDigital light processingThiol cross-linkingChemistry principlesLight processingBio-derivedCross-linkingDegradation rateElastic recoveryPhotopolymerAnhydrideSubcutaneous implantation modelBiocompatibility in vitroHigh-fidelity printingPolymerPropyleneMaterialsThiolReactionPrinted objectsComparison of 5 BMPs for their chondrogenic potentials and microfracture-mediated cartilage repair using heparin/PEAD coacervate sustained release polymer
Gao X, Wright N, Huard M, Tan J, Ruzbarsky J, Lu A, Chubb L, Tuan R, Philippon M, Wang Y, Huard J. Comparison of 5 BMPs for their chondrogenic potentials and microfracture-mediated cartilage repair using heparin/PEAD coacervate sustained release polymer. Bioactive Materials 2025, 52: 588-603. PMID: 40607117, PMCID: PMC12219002, DOI: 10.1016/j.bioactmat.2025.06.031.Peer-Reviewed Original ResearchChondrogenic differentiation of human bone marrow mesenchymal stem cellsTreatment of cartilage defectsCartilage defect repairFibrocartilage repairCartilage repairChondrogenic potentialCartilage defectsSustained release polymerChondrogenic differentiationHuman bone marrow mesenchymal stem cellsDifferentiation of human bone marrow mesenchymal stem cellsRelease polymersBone marrow mesenchymal stem cellsMarrow mesenchymal stem cellsSurgical proceduresClinical challengeMesenchymal stem cellsDefect repairStem cellsMorphogenetic proteinsOsteoarthritis treatmentRepairTreatmentPolymerMicrofractureImpact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients
Wang L, Zhuang L, Li T, Hara H, Cooper D, Leng J, Pan D, Zheng S, Wang Y, Xu X, Wei Q. Impact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients. Xenotransplantation 2025, 32: e70050. PMID: 40375623, DOI: 10.1111/xen.70050.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseEnd-stage liver disease patientsLT recipientsLiver transplantationCOVID-19 vaccineAntibody productionLiver diseaseAntibody levelsImpact of COVID-19 vaccinationTKO pig cellsLiver transplant recipientsAnti-pig antibody levelsActive COVID-19 infectionSARS-CoV-2 IgGTransplant recipientsCOVID-19 infectionEffectiveness of COVID-19 vaccinesHealthy controlsIgG levelsXenotransplant recipientsPig cellsHealthy individualsIgG antibodiesPatientsEnd-stageInterleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction
Zhang J, Rizk R, Li X, Lee B, Matthies M, Bietz K, Kim K, Huard J, Wang Y, Chen W. Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction. Frontiers In Physiology 2025, 15: 1481460. PMID: 39882328, PMCID: PMC11774956, DOI: 10.3389/fphys.2024.1481460.Peer-Reviewed Original ResearchIL-10 treatmentIL-10Dose-dependent effectMyocardial infarctionPost-MICardiac remodelingInterleukin-10Lower LV ejection fractionDoses of IL-10LV ejection fractionIL-10 administrationMyocardial gene expressionExogenous IL-10IL-10 secretionEffective dose rangePhenotypic transitionDose-dependent mannerLV fibrosisEjection fractionMouse MI modelCardiac functionCell infiltrationImmunomodulatory cytokinesContractile functionDose-dependently
2024
Pig-to-human kidney xenotransplants using genetically modified minipigs
Wang Y, Chen G, Pan D, Guo H, Jiang H, Wang J, Feng H, He S, Du J, Zhang M, Li T, Wang Y, Yu H, Gan H, Wen Q, Song Z, Li D, Yu Y, Wang H, Li B, You Y, Zhou S, Wang M, Liu L, Xu L, Yang M, Pei H, Zhang K, Chen Z. Pig-to-human kidney xenotransplants using genetically modified minipigs. Cell Reports Medicine 2024, 5: 101744. PMID: 39317190, PMCID: PMC11513830, DOI: 10.1016/j.xcrm.2024.101744.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionNatural killer (NK) cellsT cell-mediated rejectionCell-mediated rejectionHuman gene transferKidney function recoveryXenogeneic immune responsesTriple-gene knockoutPig-to-humanAcute rejectionCD40-CD154Pathway blockadeXenograft successMacrophage infiltrationXenograft functionImmunopathological changesKidney xenotransplantationBrain-dead patientsImmune responseDonor pigsFunctional recoveryClinical observationsImmunosuppressionGene transferKidneyAn unusual case of primary melioidotic prostatic disease: Misdiagnosed as benign prostatic hyperplasia
Cai Y, Jiang H, Li T, Luo D, Li P, Wang Y. An unusual case of primary melioidotic prostatic disease: Misdiagnosed as benign prostatic hyperplasia. Heliyon 2024, 10: e37906. PMID: 39323819, PMCID: PMC11422042, DOI: 10.1016/j.heliyon.2024.e37906.Peer-Reviewed Original ResearchBenign prostatic hyperplasiaProstate diseaseProstatic hyperplasiaBurkholderia pseudomallei.Urine culturePulmonary infectionTrimethoprim-sulfamethoxazoleSurvival rate of patientsTreated with imipenemUrinary tract infectionAnti-infective treatmentRate of patientsHistory of hypertensionYear old maleMultiple organ damageProstatic abscessTract infectionsInflammatory markersClinical manifestationsCure rateUnusual caseFatal infectious diseaseOrgan damageDifficulty urinatingSurvival rateClinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study
Xu L, Chen X, Yang X, Chen S, Yang M, Yuan Z, Chen R, Wang J, Jiang H, Xu J, Wang Y. Clinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study. Frontiers In Cellular And Infection Microbiology 2024, 14: 1392491. PMID: 39211792, PMCID: PMC11358093, DOI: 10.3389/fcimb.2024.1392491.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsCOVID-19 pneumoniaViral shedding timeRetrospective cohort studyShort-term prognosisTransplant recipientsClinical featuresAntiviral drugsAntiviral medicationsCohort studyShort-term renal functionAdministration of antiviral drugsAssociated with better therapeutic outcomesSevere COVID-19 pneumoniaConcurrent coronavirus disease 2019Diagnosis of COVID-19 pneumoniaTransplanted kidney functionStatistically significant reductionShedding timeRenal functionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Clinical symptomsKidney functionInitial symptomsLipocoacervate, a tunable vesicle for protein delivery
Yeh C, Wright N, Loh C, Chu N, Wang Y. Lipocoacervate, a tunable vesicle for protein delivery. Nano Research 2024, 17: 9135-9140. DOI: 10.1007/s12274-024-6889-6.Peer-Reviewed Original ResearchProtein delivery vehiclesDelivery of proteinsCells in vitroGrowth factorVesiclesProteinMembrane functionControlled delivery of growth factorsTreated cells in vitroProtein deliveryControlled DeliveryControlled delivery of proteinsDelivery of therapeuticsSalt concentrationDelivery of growth factorsMembraneVesicle sizeControlled delivery of therapeuticsCardiac regeneration in goldfish (Carassius auratus) associated with increased expression of key extracellular matrix molecules
Webb C, Wang Y. Cardiac regeneration in goldfish (Carassius auratus) associated with increased expression of key extracellular matrix molecules. The Anatomical Record 2024, 308: 1378-1390. PMID: 39092661, DOI: 10.1002/ar.25549.Peer-Reviewed Original ResearchNorbornene Dicarboximide: A Green Alternative for Thiol-Norbornene Photopolymers
Ma W, Wright N, Wang Y. Norbornene Dicarboximide: A Green Alternative for Thiol-Norbornene Photopolymers. ACS Macro Letters 2024, 13: 915-920. PMID: 38991097, DOI: 10.1021/acsmacrolett.4c00334.Peer-Reviewed Original ResearchCarbic anhydrideTunable tensile propertiesPolymer backboneDigital light processingThiol cross-linkingHuman aorta modelAnhydrideCommodity polymersPolypropylene glycolPorous scaffoldsTensile propertiesSoft materialsGreen alternativeLight processingAorta modelCross-linkingFunctional surfacesPolymerThiolPhotopolymerNorborneneAminolysisPhotoadditionStoichiometryMaterials
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