Xin Li
Associate Research ScientistCards
About
Research
Publications
2026
Clu+ transitional alveolar epithelial cells promote lung injury repair and fibrosis progression
Wang Y, Guo J, Wang Y, Liu Q, Cui Y, Ning Z, Chen Y, Liu Y, Luo Z, Gao H, Jin T, Wang X, Guo E, Zhang Y, Bian Y, Pan T, Wang S, Li X, Liang H, Gu Y. Clu+ transitional alveolar epithelial cells promote lung injury repair and fibrosis progression. British Journal Of Pharmacology 2026 PMID: 41797553, DOI: 10.1111/bph.70389.Peer-Reviewed Original ResearchRegenerating alveolar epithelial cellsAlveolar epithelial cellsEpithelial cellsSingle-cell RNA sequencingPulmonary fibrosisLung functionLung repair processLung injury repairIdiopathic pulmonary fibrosisInflammation to fibrosisFunctional assaysIntermediate subpopulationImpaired lung functionHaematoxylin-eosin stainingCross-species datasetsDays post-injuryAT1 cellsPoor prognosisProgressive inflammationLung injuryFibrosis progressionExacerbated inflammationExtracellular matrix depositionHuman MRC-5 cellsMouse modelTRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis.
Li X, Li X, Li C, Feng J, Yue Z, Yan J, Matsushita M, Qyang Y, Runnels L, Ai X, Yue L. TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis. Circulation 2026 PMID: 41645903, PMCID: PMC13019533, DOI: 10.1161/circulationaha.125.074791.Peer-Reviewed Original ResearchIschemic heart failureI/R-injured miceI/R injuryHeart failureIschemic heart diseaseTRPM7 deficiencyTRPM7 channelsCardiomyocyte deathTherapeutic strategiesInfarct sizeHeart diseaseFunction of TRPM7Activation of TRPM7Ischemia-reperfusion injuryMyocardial ischemia-reperfusion injuryKnock-In MiceNeonatal mouse cardiomyocytesIntracellular ZnTRPM7 inhibitionMyocardial I/R injuryTRPM7 expressionMouse primary cardiomyocytesPatch clampCardiac functionKnockout mice
2025
Myofibroblast specific knockdown of NSUN2 suppresses cardiac fibrosis post-myocardial infarction
Sun Z, Li N, Huang M, Li Y, Wang C, Qu Z, Yu S, Mei Z, Wu B, Dou S, Jiang J, Zhang Y, Huang C, Han J, Yue Y, Li X, Dong Y, Du W. Myofibroblast specific knockdown of NSUN2 suppresses cardiac fibrosis post-myocardial infarction. Journal Of Molecular And Cellular Cardiology 2025, 209: 27-36. PMID: 41045987, DOI: 10.1016/j.yjmcc.2025.09.009.Peer-Reviewed Original ResearchConceptsRNA modificationsRNA stabilityConditional knockdownPost-transcriptional RNA modificationsM5C RNA modificationsKnockdown of NSun2M5C methyltransferasesRNA metabolismM5C modificationExtracellular matrix componentsExcessive deposition of extracellular matrix componentsNSUN2Biological processesDeposition of extracellular matrix componentsCardiac fibrosisExcessive depositionRNACellular responsesM5CRegulatory effectsMatrix componentsTherapeutic targetHuRClinical treatmentDevelopment of cardiac fibrosisAmbient temperature and coronary plaque rupture risk in STEMI: Insights from OCT analysis
Xu Q, Jin C, Qin Z, Zhao P, Wang Y, Zhang Y, Tian Y, Li X, Li X, Yu B, Tian J. Ambient temperature and coronary plaque rupture risk in STEMI: Insights from OCT analysis. Atherosclerosis 2025, 409: 120510. PMID: 40930906, DOI: 10.1016/j.atherosclerosis.2025.120510.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionOptical coherence tomographyDay of admissionPrevalence of lipid-rich plaqueHigh riskST-segment elevation myocardial infarction patientsHighest prevalence of lipid-rich plaquesPlaque characteristicsRestricted cubic spline curvesRisk of cardiovascular eventsHighest prevalenceRupture riskElevation myocardial infarctionCulprit plaque characteristicsLipid-rich plaquesTertile-1OCT analysisCardiovascular eventsCoherence tomographyHigh risk of plaque ruptureCulprit lesionCoronary atherosclerosisIntermediate tertileMyocardial infarctionPlaque rupture riskAdvanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes
Luo H, Anderson C, Li X, Lu Y, Hoareau M, Xing Q, Fooladi S, Liu Y, Xu Z, Park J, Fallon M, Thomas J, Gruber P, Elder R, Mak M, Riaz M, Campbell S, Qyang Y. Advanced tissue-engineered pulsatile conduit using human induced pluripotent stem cell-derived cardiomyocytes. Acta Biomaterialia 2025, 211: 92-103. PMID: 40582540, PMCID: PMC12338880, DOI: 10.1016/j.actbio.2025.06.055.Peer-Reviewed Original ResearchSingle ventricle congenital heart defectsHuman induced pluripotent stem cell-derived cardiomyocytesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesCongenital heart defectsHuman umbilical arteryUmbilical arteryHeart defectsPulmonary circulationDecellularized human umbilical arteriesHeart tissueLife-threatening defectsLife-threatening disorderLong-term complicationsEngineered Heart TissueFontan surgeryFunctioning ventriclePrompt treatmentHeart failureSpontaneous beatingPump functionImprove outcomesPressure generationConventional treatmentNew Schinortriterpenoids Including an Unprecedented 7/5/5/5 Carbon Skeleton with Antineuroinflammatory Activity from Leaves of Schisandra chinensis
Zhang Y, Li X, Liu X, Zhang Q, Jiang P, Xu W, Lu D, Luo Y, Pan J, Guan W, Li M, Chen Q, Zhang L, Kuang H, Yang B, Liu Y. New Schinortriterpenoids Including an Unprecedented 7/5/5/5 Carbon Skeleton with Antineuroinflammatory Activity from Leaves of Schisandra chinensis. Journal Of Agricultural And Food Chemistry 2025, 73: 18939-18952. PMID: 40561195, DOI: 10.1021/acs.jafc.5c02110.Peer-Reviewed Original ResearchConceptsX-ray crystallographic analysisLeaves of Schisandra chinensisAntineuroinflammatory activityAbsolute configurationECD calculationsCrystallographic analysisSchinortriterpenoidsChemical structureCarbon skeletonX-rayBV-2 microglial cellsCompoundsBV-2BV-2 cell lineSignaling pathwayBV-2 cellsChinese folk medicineCell linesECDZLY032 mediated activation of Notch1/Hes1 signaling inhibits cardiomyocyte ferroptosis to protect against myocardial Ischemia-Reperfusion injury in mice
Li H, Liu D, Gong M, Zhang Y, Liu J, Ren J, Cheng M, Zhang Y, Wang H, Wang S, Huang J, Feng X, Jiang S, Li X, Liu T, Yang M, Liu W, Jiao L, Li M, Zhang Y. ZLY032 mediated activation of Notch1/Hes1 signaling inhibits cardiomyocyte ferroptosis to protect against myocardial Ischemia-Reperfusion injury in mice. Biochemical Pharmacology 2025, 239: 117039. PMID: 40499841, DOI: 10.1016/j.bcp.2025.117039.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryMyocardial ischemia-reperfusion injuryNotch1/Hes1 signaling pathwayCardiomyocyte ferroptosisMyocardial I/R injuryPatient prognosisI/R injuryCardiac contractile impairmentSignaling pathwayIschemia/reperfusion (I/R) injuryProtein stabilityMyocardial ischemia/reperfusion (I/R) injuryActivation of Notch1Contractile impairmentCardioprotective roleCardioprotective effectsSurvival rateLevels of lipid peroxidationInfarct areaCardiomyocytesTherapeutic agentsNotch1/Hes1 signalingProtective effectInjuryFerroptosisDiscovery of schinortriterpenoids schisaterpenes O–R from the fruits of Schisandra chinensis via molecular networking
Jiang P, Luo Y, Li X, Liu X, Zhang S, Guan W, Zhang Y, Hao Z, Chen Q, Zhang L, Yao H, He X, Kuang H, Yang B, Liu Y. Discovery of schinortriterpenoids schisaterpenes O–R from the fruits of Schisandra chinensis via molecular networking. Journal Of Molecular Structure 2025, 1333: 141765. DOI: 10.1016/j.molstruc.2025.141765.Peer-Reviewed Original ResearchInteraction region indicatorDensity functional theoryMolecular orbitalsCompound 4Compounds 1Properties of compounds 1Electronic propertiesDP4+ analysisNMR calculationsMolecular docking analysisECD calculationsFunctional theorySchinortriterpenoidsEnergy gapExtract of Schisandra chinensisDocking analysisCompoundsCalculationsMolecular networksNMRO-ringsECDDP4Neuroprotective activityRegional indicatorsDiscovery of undescribed schinortriterpenoids from Schisandra chinensis by molecular networking and their neuroprotective effects
Jiang P, Luo Y, Li X, Zhang S, Guan W, Anam-Naseem, Fan Y, Chen Q, Zhang L, Yao H, He X, Kuang H, Yang B, Liu Y. Discovery of undescribed schinortriterpenoids from Schisandra chinensis by molecular networking and their neuroprotective effects. Phytochemistry 2025, 237: 114524. PMID: 40306533, DOI: 10.1016/j.phytochem.2025.114524.Peer-Reviewed Original ResearchConceptsAnti-neuroinflammatory activityQuantum chemical calculationsX-ray diffraction analysisHR-ESI-MSChemical calculationsCompound 11Compound 8Diffraction analysisSchinortriterpenoidsMolecular networking techniquesX-rayRipe fruitsMicroglial BV-2 cellsCompoundsMolecular networksNMRSchisandraceae familyMedicinal valueBV-2 cellsSchisandra chinensisChinese medicineUnveiling a novel cancer hallmark by evaluation of neural infiltration in cancer
Dong Q, Guo Y, Lv C, Ren L, Chen B, Wang Y, Liu Y, Liu M, Liu K, Zhang N, Wang L, Sang S, Li X, Hui Y, Liang H, Gu Y. Unveiling a novel cancer hallmark by evaluation of neural infiltration in cancer. Briefings In Bioinformatics 2025, 26: bbaf082. PMID: 40052442, PMCID: PMC11886572, DOI: 10.1093/bib/bbaf082.Peer-Reviewed Original ResearchConceptsCancer hallmarksSingle-cell RNA sequencing datasetsRNA-seq datasetsTumor microenvironmentNeural infiltrationCopy number variationsRNA sequencing datasetsEpithelial cellsRNA-seqSequencing datasetsNumber variationsEpithelial-mesenchymal transition scoresCancer typesMultiple cancer typesAntitumor immune cellsNeural genesSchwann cellsSignaling pathwayCell differentiationEffective therapeutic strategyCancer cellsCell typesCo-culture experimentsCancer samplesCancer progression