Xiaoyong Chen, PhD
Associate Research Scientist in Therapeutic RadiologyCards
Appointments
Therapeutic Radiology
Primary
Contact Info
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Titles
Associate Research Scientist in Therapeutic Radiology
Appointments
Therapeutic Radiology
Associate Research ScientistPrimary
Other Departments & Organizations
- Radiobiology
- Therapeutic Radiology
Education & Training
- PhD
- University of Western Ontario (1993)
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Xiaoyong Chen's published research.
James E. Hansen, MD, MS
Jiangbing Zhou, PhD
Fengshan Liang, PhD
Manoj M Pillai, MBBS, MD
Melissa Rasar Young, MD, PhD
Prajwal Boddu, MD, PhD
Publications
2025
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Chen X, Tang X, Xie Y, Cuffari B, Tang C, Cao F, Gao X, Meng Z, Noble P, Young M, Turk O, Shirali A, Gera J, Nishimura R, Zhou J, Hansen J. A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells. Science Signaling 2025, 18: eadk3320-eadk3320. PMID: 40132052, PMCID: PMC12076517, DOI: 10.1126/scisignal.adk3320.Peer-Reviewed Original ResearchThis study investigates a lupus-derived autoantibody's ability to activate tumor immunity via intracellular RNA-binding and cGAS activation, improving glioblastoma survival and enabling RNA delivery into cells.
2024
Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy
Cao F, Tang C, Chen X, Tu Z, Jin Y, Turk O, Nishimura R, Ebens A, Dubljevic V, Campbell J, Zhou J, Hansen J. Cathepsin B Nuclear Flux in a DNA-Guided “Antinuclear Missile” Cancer Therapy. ACS Central Science 2024, 10: 1562-1572. PMID: 39220699, PMCID: PMC11363321, DOI: 10.1021/acscentsci.4c00559.Peer-Reviewed Original ResearchCitationsAltmetricThe FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
Olazabal-Herrero A, He B, Kwon Y, Gupta A, Dutta A, Huang Y, Boddu P, Liang Z, Liang F, Teng Y, Lan L, Chen X, Pei H, Pillai M, Sung P, Kupfer G. The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export. Cell Reports 2024, 43: 113610. PMID: 38165804, PMCID: PMC10865995, DOI: 10.1016/j.celrep.2023.113610.Peer-Reviewed Original ResearchCitationsAltmetric
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