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Research Associate Internal Medicine Cardiology
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Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Xiaohong Wu's published research.
Brandon T. Hubbard
Dongyan Zhang
Fadi Gabriel Akar, PhD
Gary Cline, PhD
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
Jiasheng Zhang, MD
Publications
2026
Cardiac STIM1 deficiency triggers mitochondrial fission to impair electrophysiological function and exacerbate post-MI remodeling
Cacheux M, Velasco J, Granger J, Wu X, Strauss B, Akar F. Cardiac STIM1 deficiency triggers mitochondrial fission to impair electrophysiological function and exacerbate post-MI remodeling. Heart Rhythm 2026 PMID: 42019797, PMCID: PMC13161530, DOI: 10.1016/j.hrthm.2026.04.030.Peer-Reviewed Original ResearchAltmetricConceptsStromal interaction molecule 1Mitochondrial CaPost-MI remodelingVentricular dysfunctionIschemia/reperfusion injuryDelivery of short hairpin RNAAssessment of ventricular functionSevere ventricular dysfunctionVentricular systolic functionConnexin-43 expressionSpatially discordant alternansAction potential mappingTransients in vitroCentral regulatorMyocyte contractilityShort hairpin RNASTIM1 knockdownSystolic functionSTIM1 deficiencyVentricular functionCardiac functionConnexin-43Transient amplitudeAdverse post-MI remodelingDynamic protein expression
2024
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts
Goedeke L, Ma Y, Gaspar R, Nasiri A, Lee J, Zhang D, Galsgaard K, Hu X, Zhang J, Guerrera N, Li X, LaMoia T, Hubbard B, Haedersdal S, Wu X, Stack J, Dufour S, Butrico G, Kahn M, Perry R, Cline G, Young L, Shulman G. SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. Journal Of Clinical Investigation 2024, 134: e176708. PMID: 39680452, PMCID: PMC11645152, DOI: 10.1172/jci176708.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSodium-glucose cotransporter type 2Heart failureKetone oxidationGas chromatography-mass spectrometryFatty acid oxidationLeft ventricular ejection fractionReduced myocardial oxidative stressVentricular ejection fractionKetone supplementationWeeks of treatmentMyocardial oxidative stressDecreased pyruvate oxidationInduce heart failurePlasma glucose levelsIn vivo effectsSGLT2i treatmentEjection fractionAssociated with improvementsAwake ratsSGLT2 inhibitionCardioprotective benefitsLiquid chromatography-tandem mass spectrometryPlasma ketonesRates of ketonizationChromatography-tandem mass spectrometry
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- April 27, 2026
Yale Department of Internal Medicine Celebrates Staff Service Anniversaries
- February 18, 2025
What Makes a Successful Heart Failure Drug Work?
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