Uma Krishnamurti, MD, MBBS, PhD
Professor of Pathology and Director of Breast PathologyCards
About
Titles
Professor of Pathology and Director of Breast Pathology
Director of Breast Pathology, Pathology
Biography
Dr. Krishnamurti is a pathologist with expertise in breast pathology, cytopathology, and gynecologic pathology. She completed her residency training in Anatomic and Clinical Pathology at the University of Minnesota and the University of Pittsburgh followed by a Fellowship in Cytopathology at the University of Pittsburgh. She joined the faculty at Yale in 2021, where she is currently Professor of Pathology and Director of Breast Pathology. She has been the primary author of the College of American Pathologists (CAP) gynecologic cancer reporting synoptic templates. She served as Principal Investigator and Director of the Breast Satellite Tissue Bank of Winship Cancer Institute, Emory University, from 2015 to 2021. Her main areas of academic interest include diagnostic, prognostic, and predictive markers of triple-negative and HER2-positive breast cancer.
Dr. Krishnamurti has been a course faculty at the American Society of Cytopathology (ASC), American Society for Clinical Pathology (ASCP), and College of American Pathologists (CAP) annual meetings. She has Chaired the Research and Current Concepts Committee of the ASC and served as a member of the American Joint Commission on Cancer Expert Panel on Protocol for Cancer Staging of the Vulva. Currently, Dr. Krishnamurti serves on the Breast section of the Cancer Committee of the CAP, and on the ASC Bulletin and Cytopath Podcast Committee.
Last Updated on February 03, 2023.
Appointments
Pathology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- University of Pittsburgh (2004)
- Residency
- University of Pittsburgh (2003)
- PhD
- University of Minnesota (1999)
- MD
- University of Delhi (1990)
- MBBS
- University of Delhi (1985)
Board Certifications
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2003
Research
Publications
2025
Gynecologic Cytology and Pap Smears
Krishnamurti U, Mosunjac M, Deftereos G. Gynecologic Cytology and Pap Smears. 2025, 1751-1803. DOI: 10.1007/978-981-97-4822-8_40.Peer-Reviewed Original ResearchAmerican Cancer SocietyCervical cancerCases of invasive cervical cancerParaffin-embedded histological samplesOncogenic HPV typesInvasive cervical cancerCancer SocietyDetection of HPVDNA in situ hybridizationCervical cancer screeningHPV genotypesHPV DNAHPV statusP16 immunohistochemistryCervical cytologyHPV typesBethesda systemHPV biologyHPVFormalin-fixedCancer screeningPrognostic reasonsHistological samplesScreening strategiesManagement guidelinesC/EBPβ increases tumor aggressiveness by enhancing KIFC1 expression in androgen receptor negative triple negative breast cancer
Joshi S, Garlapati C, Nguyen T, Sharma S, Chandrashekar D, Bhattarai S, Varambally S, Krishnamurti U, Li X, Aneja R. C/EBPβ increases tumor aggressiveness by enhancing KIFC1 expression in androgen receptor negative triple negative breast cancer. Cell Communication And Signaling 2025, 23: 255. PMID: 40448099, PMCID: PMC12125945, DOI: 10.1186/s12964-025-02243-7.Peer-Reviewed Original ResearchConceptsHuman epidermal growth factor receptor 2Expression of estrogen receptorAndrogen receptorAggressive characteristicsEpithelial-mesenchymal transitionProgesterone receptorPoor prognosisBreast cancerLack of AR expressionQuadruple-negative breast cancerEpidermal growth factor receptor 2Triple-negative breast tumorsKIFC1 expressionTriple negative breast cancerExpression of therapeutic targetsReduced tumor volumeTherapeutic targetNegative breast cancerRisk predictive biomarkersPromote epithelial-mesenchymal transitionExpression of KIFC1Cancer cell proliferationTumor volumeAR expressionTumor aggressivenessHuman papillomavirus genotype distribution and its correlation with intraepithelial neoplasia, vaccination, and ethnicity
Abi-Raad R, Sun T, Krishnamurti U. Human papillomavirus genotype distribution and its correlation with intraepithelial neoplasia, vaccination, and ethnicity. Journal Of The American Society Of Cytopathology 2025, 14: 273-278. PMID: 40307088, DOI: 10.1016/j.jasc.2025.03.006.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusNon-16/18ASC-HHPV genotypesIntraepithelial neoplasiaCases of high-grade squamous intraepithelial lesionCervical cancerPositive high-risk HPVHigh-risk HPVHigh-risk human papillomavirus genotypesHuman papillomavirus genotype distributionNon-16/18 HPV genotypesPrevalence of HPV genotypesHigh-risk human papillomavirus typesHigh-grade intraepithelial neoplasiaIntroduction of HPV vaccinationIncidence of cervical cancerAtypical squamous cellsSquamous intraepithelial lesionsHigh-grade lesionsHSIL patientsNonvaccinated womenIntraepithelial lesionsVaccinated womenSquamous cellsPTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence
Zhan H, Antony V, Tang H, Theriot J, Liang Y, Hui P, Krishnamurti U, DiGiovanna M. PTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence. Breast Cancer Research And Treatment 2025, 211: 441-447. PMID: 40063317, DOI: 10.1007/s10549-025-07660-3.Peer-Reviewed Original ResearchConceptsPten inactivating mutationsBreast cancerER+/HER2- tumorsRecurrent tumorsER+/HER2- breast cancer patientsInactivating mutationsAssociated with worse clinical outcomesTreatment historyER+/HER2- breast cancerTriple negative phenotypeBreast cancer recurrenceBreast cancer patientsHormone receptor lossResultsThe average timeHR+ tumorsDistant recurrenceHR statusER expressionRecurrent diseaseTumor histologyTumor recurrenceHER2 expressionHormone independencePatient ageClinicopathological characteristics340 Cytomorphologic Challenges in Cervical Pap Tests of Transgender Men on Androgen Therapy: A Cyto-Histological Correlation Study
Haque M, Amraei R, Iyer K, Krishnamurti U, Adeniran A, Sun T. 340 Cytomorphologic Challenges in Cervical Pap Tests of Transgender Men on Androgen Therapy: A Cyto-Histological Correlation Study. Laboratory Investigation 2025, 105: 102567. DOI: 10.1016/j.labinv.2024.102567.Peer-Reviewed Original Research401 Prognostic Value of Pelvic Washing Cytology in Early-Stage Endometrial Cancer: A 10-Year Single-Institute Cohort Study
Wang M, Abi-Raad R, Krishnamurti U, Cai G, Adeniran A, Sun T. 401 Prognostic Value of Pelvic Washing Cytology in Early-Stage Endometrial Cancer: A 10-Year Single-Institute Cohort Study. Laboratory Investigation 2025, 105: 102628. DOI: 10.1016/j.labinv.2024.102628.Peer-Reviewed Original Research116 Pathological and Molecular Characterization of Estrogen Receptor-Positive/HER2-Negative de novo Metastatic Breast Cancer
Babb P, Theriot J, Liang Y, Cartagena L, Buza N, Krishnamurti U, Zhan H. 116 Pathological and Molecular Characterization of Estrogen Receptor-Positive/HER2-Negative de novo Metastatic Breast Cancer. Laboratory Investigation 2025, 105: 102340. DOI: 10.1016/j.labinv.2024.102340.Peer-Reviewed Original Research213 Focal Atypical Ductal Hyperplasia (ADH) Upgrade Rate with Radiological Correlation: A Single Institution Study
Podany P, Kahila M, Proussaloglou E, Lewin J, Andrejeva L, Krishnamurti U. 213 Focal Atypical Ductal Hyperplasia (ADH) Upgrade Rate with Radiological Correlation: A Single Institution Study. Laboratory Investigation 2025, 105: 102437. DOI: 10.1016/j.labinv.2024.102437.Peer-Reviewed Original Research214 Histologic Analysis and Clinical Correlation of Atypical Apocrine Lesions
Podany P, Zhan H, Cartagena L, Krishnamurti U, Liang Y. 214 Histologic Analysis and Clinical Correlation of Atypical Apocrine Lesions. Laboratory Investigation 2025, 105: 102438. DOI: 10.1016/j.labinv.2024.102438.Peer-Reviewed Original Research129 Unmasking Adenomyoepithelial Lesions of the Breast: A Review of 29 Cases
Cartagena L, Liang Y, Zhan H, Krishnamurti U. 129 Unmasking Adenomyoepithelial Lesions of the Breast: A Review of 29 Cases. Laboratory Investigation 2025, 105: 102353. DOI: 10.1016/j.labinv.2024.102353.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- June 12, 2025
Pathology, Laboratory Medicine Residents, Fellows Feted at Graduation Ceremony
- March 01, 2024
Connecticut Society of Pathologists' Educational Meeting Draws Pathologists from Across the State
- December 19, 2023
Yale Pathologists Lead Effort to Revitalize Connecticut Society of Pathologists
- November 14, 2022
Yale Pathologists to Collaborate with African Physicians at Inaugural PEACE Symposium