Uma Krishnamurti, MD, MBBS, PhD
Professor of Pathology and Director of Breast PathologyCards
About
Titles
Professor of Pathology and Director of Breast Pathology
Director of Breast Pathology, Pathology
Biography
Dr. Krishnamurti is a pathologist with expertise in breast pathology, cytopathology, and gynecologic pathology. She completed her residency training in Anatomic and Clinical Pathology at the University of Minnesota and the University of Pittsburgh followed by a Fellowship in Cytopathology at the University of Pittsburgh. She joined the faculty at Yale in 2021, where she is currently Professor of Pathology and Director of Breast Pathology. She has been the primary author of the College of American Pathologists (CAP) gynecologic cancer reporting synoptic templates. She served as Principal Investigator and Director of the Breast Satellite Tissue Bank of Winship Cancer Institute, Emory University, from 2015 to 2021. Her main areas of academic interest include diagnostic, prognostic, and predictive markers of triple-negative and HER2-positive breast cancer.
Dr. Krishnamurti has been a course faculty at the American Society of Cytopathology (ASC), American Society for Clinical Pathology (ASCP), and College of American Pathologists (CAP) annual meetings. She has Chaired the Research and Current Concepts Committee of the ASC and served as a member of the American Joint Commission on Cancer Expert Panel on Protocol for Cancer Staging of the Vulva. Currently, Dr. Krishnamurti serves on the Breast section of the Cancer Committee of the CAP, and on the ASC Bulletin and Cytopath Podcast Committee.
Appointments
Pathology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- University of Pittsburgh (2004)
- Residency
- University of Pittsburgh (2003)
- PhD
- University of Minnesota (1999)
- MD
- University of Delhi (1990)
- MBBS
- University of Delhi (1985)
Board Certifications
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2003
Research
Publications
2024
Distribution of HPV 16/18 by Ethnicity and Correlation with HPV Vaccination Status
Abi-Raad R, Krishnamurti U. Distribution of HPV 16/18 by Ethnicity and Correlation with HPV Vaccination Status. Journal Of The American Society Of Cytopathology 2024, 13: s29. DOI: 10.1016/j.jasc.2024.08.052.Peer-Reviewed Original ResearchClinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer.
Sun T, Golestani R, Zhan H, Krishnamurti U, Harigopal M, Zhong M, Liang Y. Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer. International Journal Of Surgical Pathology 2024, 10668969241256109. PMID: 38839260, DOI: 10.1177/10668969241256109.Peer-Reviewed Original ResearchBreast cancerCopy number amplificationClinicopathological characteristicsAssociation with <i>TP53</i> mutation. InAssociated with invasive ductal carcinomaEstrogen receptor (ER)-negativeDisease-free survival timeGene copy number amplificationC-myc immunostainingNon-amplified tumorsTP53</i> mutationsTriple-negative statusMetastatic breast cancerInvasive ductal carcinomaMYC protein overexpressionBreast cancer patientsTriple-negativeDuctal carcinomaClinicopathological featuresGenetic abnormalitiesClinical dataImmunohistochemical studiesCancer patientsProtein overexpressionSurvival timeChanging digital and telecytology practices post COVID-19 comparing ASC survey results from 2016 to 2023
Chen-Yost H, Bammert C, Hao W, Heymann J, Lin D, Marotti J, Waraksa-Deutsch T, Huang M, Krishnamurti U, Lin O, Ly A, Moatamed N, Pantanowitz L, Roy-Chowdhuri S. Changing digital and telecytology practices post COVID-19 comparing ASC survey results from 2016 to 2023. Journal Of The American Society Of Cytopathology 2024, 13: 194-204. PMID: 38582697, DOI: 10.1016/j.jasc.2024.02.004.Peer-Reviewed Original Research
2023
HER2 amplification in cases with low HER2 expression by immunohistochemistry (IHC): A Single Institutional Experience
Podany P, Golastani R, Zhan H, Liang Y, Harigopal M, Krishnamurti U. HER2 amplification in cases with low HER2 expression by immunohistochemistry (IHC): A Single Institutional Experience. American Journal Of Clinical Pathology 2023, 160: s9-s10. DOI: 10.1093/ajcp/aqad150.021.Peer-Reviewed Original ResearchLow HER2 expressionInvasive breast carcinomaIHC scoreHER2 expressionGroup 1Group 3HER2 immunohistochemistryHER2 testingGroup 2HER2 FISHGroup 4ASCO/CAP guidelinesGroup 5Single institutional experienceRecent clinical trialsStandard of careASCO/CAP 2018 guidelinesHER2/CEP17 ratioEquivocal HER2HER2 positivityTrastuzumab deruxtecanMore patientsCAP guidelinesPatient eligibilityCase reportAn Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy
Mudrinich S, Nguyen M, Blemur D, Wang X, Wang Y, Krishnamurti U, Mosunjac M, Flowers L. An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy. Journal Of Lower Genital Tract Disease 2023, 28: 101-106. PMID: 38117565, DOI: 10.1097/lgt.0000000000000773.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirus (hrHPV) testingLow CD4 countRisk factorsTriage toolAnal cytologyCD4 countTransgender womenAdult cisgender menHigh-Resolution AnoscopyHuman papillomavirus testingCisgender menPredictive risk factorsRetrospective cohort studySignificant risk factorsSociodemographic risk factorsNegative predictive valueNovel triage toolHrHPV positivityUnderwent cytologyHrHPV testingCohort studyAnal neoplasiaScreening patternsPredictive valueHIVBreast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review
Carrasco-Tenezaca F, Moreira-Dinzey J, Manrai P, Bearse M, Burela S, Podany P, Singh K, Pareja F, Zheng J, Muscato N, Liang Y, Zhan H, Krishnamurti U, Dolezal D, Wang J, Harigopal M. Breast Carcinoma With Tubulopapillary Features Has a Distinct Immunophenotypic and Molecular Signature: A Report of Two Tumors and Literature Review. International Journal Of Surgical Pathology 2023, 32: 1037-1045. PMID: 37908113, DOI: 10.1177/10668969231209780.Peer-Reviewed Original ResearchBreast carcinomaTubulopapillary featuresHuman epidermal growth factor 2 (HER2) expressionBreast cancer histologic subtypesNonmetastatic breast carcinomaTriple-negative profileHigh-grade nuclear featuresTriple-negative carcinomasHigh-grade featuresMetastatic breast carcinomaGrowth factor 2 expressionFactor 2 expressionReports of tumorsMicropapillary projectionsNeoadjuvant therapyHistologic subtypeWorse prognosisFirst tumorPoor prognosisAdditional tumorsInvasive carcinomaEstrogen receptorCarcinomaPathogenic variantsTumorsThe correlation of ESR1 genetic aberrations with estrogen receptor and progesterone receptor status in metastatic and primary estrogen receptor-positive breast carcinomas
Moreira-Dinzey J, Zhan H, Rozenblit M, Krishnamurti U, Harigopal M, Zhong M, Liang Y. The correlation of ESR1 genetic aberrations with estrogen receptor and progesterone receptor status in metastatic and primary estrogen receptor-positive breast carcinomas. Human Pathology 2023, 137: 56-62. PMID: 37127079, DOI: 10.1016/j.humpath.2023.04.017.Peer-Reviewed Original ResearchConceptsMetastatic tumorsBreast carcinomaGenetic aberrationsPR statusPrimary tumorBreast cancerControl groupER/PR statusEstrogen receptor-positive breast carcinomasER-positive breast cancerER positivity rateMetastatic breast cancerProgesterone receptor statusMetastatic breast carcinomaMore liver metastasesPrimary breast carcinomaWild-type groupEstrogen receptor 1 geneReceptor 1 geneWild-type controlsLiver metastasesReceptor statusClinicopathological featuresER expressionControl tumors
2022
Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital
Dababneh M, Birdsong G, Mosunjac M, Krishnamurti U. Human papillomavirus 16/18/45 are not the most frequent genotypes in African American women: analysis in cervical Papanicolaou smears of women in an inner-city hospital. Journal Of The American Society Of Cytopathology 2022, 12: 120-125. PMID: 36585313, DOI: 10.1016/j.jasc.2022.11.005.Peer-Reviewed Original ResearchConceptsHR-HPV genotypesAfrican American womenIntraepithelial lesionsPap testHigh-grade squamous intraepithelial lesion casesHigh-grade squamous intraepithelial lesionsCommon high-risk HPVHPV molecular testingHigh-risk HPVSquamous intraepithelial lesionsCervical Pap testBethesda classification systemCommon human papillomavirusCervical Papanicolaou smearsInner-city hospitalSecondary prevention methodsAmerican womenHR-HPVHPV vaccineHPV genotypesCervical cancerHuman papillomavirusPapanicolaou smearsAfrican American populationLesion casesFurther Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis
Liang Y, Zhan H, Krishnamurti U, Harigopal M, Sun T. Further Characterization of Clinicopathologic Features of Cystic Neutrophilic Granulomatous Mastitis. American Journal Of Clinical Pathology 2022, 158: 488-493. PMID: 35899981, DOI: 10.1093/ajcp/aqac074.Peer-Reviewed Original ResearchConceptsCystic neutrophilic granulomatous mastitisGranulomatous mastitisClinicopathologic characteristicsClinicopathologic featuresHigher Breast Imaging ReportingUnique infectious diseaseHospital-based cohortDistinct clinicopathologic featuresMass-like lesionCase-control studyData System scoreBreast Imaging ReportingPainful lesionsRadiologic studiesClinicopathologic profileSystem scoreImaging ReportingDemographic featuresInfectious diseasesPatientsLesionsDiseaseMastitisFurther characterizationSmokersNeighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities
Gohar J, Do W, Miller-Kleinhenz J, Conneely K, Krishnamurti U, D’Angelo O, Gogineni K, Torres M, Gabram-Mendola S, McCullough L. Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities. Breast Cancer Research And Treatment 2022, 191: 653-663. PMID: 34978015, DOI: 10.1007/s10549-021-06430-1.Peer-Reviewed Original ResearchConceptsNeighborhood-level factorsCause mortalityMultivariable Cox proportional hazards modelsCox proportional hazards modelCancer outcome disparitiesBreast cancer outcomesTumor methylationProportional hazards modelNon-Hispanic blacksArea-level factorsCancer outcomesFalse discovery rate thresholdBody of evidenceCancer disparitiesBreast cancerOutcome disparitiesCpG sitesTumor progressionTumor tissueWhite womenGuanine dinucleotide sitesRacial disparitiesMortalityTumor epigenomeLinear regression models
Academic Achievements & Community Involvement
News
News
- March 01, 2024
Connecticut Society of Pathologists' Educational Meeting Draws Pathologists from Across the State
- December 19, 2023
Yale Pathologists Lead Effort to Revitalize Connecticut Society of Pathologists
- November 14, 2022
Yale Pathologists to Collaborate with African Physicians at Inaugural PEACE Symposium
- May 31, 2022
Uma Krishnamurti, MBBS, MD, PhD, Named New Director of Yale Breast Pathology