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Professor of Nursing
Biography
Dr. Knobf holds a master's degree from the Yale School of Nursing and a nursing doctorate from University of Pennsylvania. Dr. Knobf's clinical practice with women with breast cancer over the past three decades has been foundational to her clinical scholarship and program of research. Her initial research study on the phenomena of weight gain in women with breast cancer on adjuvant therapy, published in 1983, resulted from the observed distress of the women experiencing a change in weight. The concept of symptom distress became an integral component in her research.
Leadership in Oncology Nursing began early in her career, being elected to the Board of Directors of the Oncology Nursing Society in 1977. Dr. Knobf's contributions to nursing have been recognized through multiple awards including the Oncology Nursing Society Excellence in Breast Cancer Education award, the Yale School of Nursing Annie Goodrich Teaching award, American Cancer Society Bronze Medal, Distinguished Service award and was the American Cancer Society Professor of Oncology Nursing. Dr. Knobf's expertise has interdisciplinary recognition and she has been selected to participate in national forums related to breast cancer.
Last Updated on April 07, 2025.
Departments & Organizations
- Cancer Prevention and Control
- Nursing Website
- Obesity Research Working Group
- Yale Cancer Center
Research
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Overview
Medical Research Interests
Chemotherapy, Adjuvant
ORCID
0000-0001-6939-8262
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tish Knobf's published research.
Publications Timeline
A big-picture view of Tish Knobf's research output by year.
Research Interests
Research topics Tish Knobf is interested in exploring.
Shelli Feder, PhD, APRN, FNP (BC), ACHPN, FAAN
Lois S. Sadler, FAAN, RN, PhD
Prasanna Ananth, MD, MPH
Arietta Slade, PhD
Janene Batten, EdD, MLS
Karl Insogna, MD, FACP
52Publications
1,175Citations
Chemotherapy, Adjuvant
Publications
2025
Psychometric evaluation of the Chinese version of Templer’s death anxiety scale using item response theory
Chen F, Deng Y, Li S, Zhang Q, Knobf M, Ye Z. Psychometric evaluation of the Chinese version of Templer’s death anxiety scale using item response theory. Measurement And Evaluations In Cancer Care 2025, 3: 100012. DOI: 10.1016/j.ymecc.2024.100012.Peer-Reviewed Original ResearchConceptsMokken scale analysisTempler's Death Anxiety ScaleEvaluate death anxietyDifferential item functioningDeath Anxiety ScaleDeath anxietyFear of deathItem response theoryChinese versionCancer patientsChinese cancer patientsAnxiety ScaleAcceptance of deathItem response theory analysisDifferential item functioning analysisGender differencesPsychometric evaluationItem functioningModerate difficultyAnxietyLocal independenceResponse theoryItemsIncreasing recognitionFearPreparing for a Child's End of Life: Parent Perspectives.
Ouyang N, Backman M, Knobf M, Snaman J, Baker J, Ananth P, Feder S. Preparing for a Child's End of Life: Parent Perspectives. 2025 PMID: 40930538, DOI: 10.1542/peds.2025-072257.Peer-Reviewed Original ResearchCitationsAltmetricConceptsChild's endBereaved parentsChild's end of lifeChild deathsNon-Hispanic white mothersEOL decision-makingDevelopment of targeted interventionsEnd of lifeParental psychological symptomsQualitative descriptive studyEOL careDying childrenClinician communicationPeer supportSemistructured interviewsImpending deathClinician's difficultyPatient careThematic analysisDescriptive studyPsychological symptomsParents' perspectivesParental preparationWhite mothersCareContemporaneous and temporal symptom drivers during breast cancer chemotherapy: A prospective repeated-measures cohort study
Liang M, Li J, Xiang J, Zeng Y, Li S, Chen F, Pan Y, Zhong T, Chen L, Mei X, Zhou J, Xu M, Li J, Knobf M, Ye Z. Contemporaneous and temporal symptom drivers during breast cancer chemotherapy: A prospective repeated-measures cohort study. European Journal Of Oncology Nursing 2025, 78: 102944. PMID: 41004877, DOI: 10.1016/j.ejon.2025.102944.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProspective cohort studyExploratory factor analysisConfidence intervalsStage I-III breast cancerSymptom clustersMD Anderson Symptom InventoryI-III breast cancerProspective cohort study of patientsCohort study of patientsStable symptom clustersSymptom managementSymptom InventorySomatic symptomsNon-parametric bootstrappingBreast cancer chemotherapyIntervention targetsStudy of patientsSymptom effectsEarly interventionShortness of breathBreast cancerLoss of appetiteFactor analysisT1-T3Chemotherapy cyclesSelf-perceived burden, fear of progression and psychological flexibility in cervical cancer survivors: A moderated network analysis
Zhang Q, Chen F, Xiao Z, Li S, Deng Y, Knobf M, Li J, Ye Z. Self-perceived burden, fear of progression and psychological flexibility in cervical cancer survivors: A moderated network analysis. Asia-Pacific Journal Of Oncology Nursing 2025, 12: 100762. PMID: 40821968, PMCID: PMC12355130, DOI: 10.1016/j.apjon.2025.100762.Peer-Reviewed Original ResearchConceptsSelf-perceived burdenFear of progressionCervical cancer survivorsPatient psychological distressCancer survivorsPsychological flexibilitySPBS-CPFear of progression questionnaire-short formACT-based interventionModerate levelsCross-sectional studyJohnson-Neyman analysisLevels of PFCervical cancerPsychological distressOverall distressPsychological burdenSelf-perceivedMean scoreSurvivorsCancer patientsBurdenDistressFearAssociationFear of cancer recurrence and perceived pain in patients with breast cancer: A network analysis approach
Chen F, Deng Y, Li S, Zhang Q, Xiao Z, Knobf M, Ye Z. Fear of cancer recurrence and perceived pain in patients with breast cancer: A network analysis approach. Asia-Pacific Journal Of Oncology Nursing 2025, 12: 100763. PMID: 40821967, PMCID: PMC12355119, DOI: 10.1016/j.apjon.2025.100763.Peer-Reviewed Original ResearchCitationsConceptsFear of cancer recurrencePain catastrophizingFear of Cancer Recurrence InventoryBreast cancerTotal scorePain Catastrophizing ScaleCancer recurrenceCatastrophizing ScalePerceived PainPersonalized interventionsIntervention targetsEligible patientsSymptom activityInterventionPainBreastMulti-center trialScoresFearCancerCentral symptomsSymptomsAnalysis approachPatientsDirect relationshipDemoralization and depression in breast cancer: A Bayesian network and computer-simulated intervention study
Xiong Y, Li H, Yu M, Deng Y, Zhang Q, Li S, Li J, Knobf M, Ye Z. Demoralization and depression in breast cancer: A Bayesian network and computer-simulated intervention study. European Journal Of Oncology Nursing 2025, 78: 102938. PMID: 40714677, DOI: 10.1016/j.ejon.2025.102938.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsCancer survivorsHospital Anxiety and Depression ScaleAnxiety and Depression ScaleDemoralization Scale-IIDepression ScaleDepression subscaleDepressive symptomsBreast cancer patientsCausal pathwaysIntervention studiesSymptom interactionsScale IIDemoralizationFostering optimismDepressionDepression clusterBreast cancerCancer patientsDistressInterventionBreastSurvivorsSymptomsCausal directionPost-traumatic stress disorder, resilience and cancer-related fatigue in breast cancer: A moderated network analysis
Li H, Xiong Y, Zhang Q, Lu Y, Chen Q, Wu S, Deng Y, Zhao J, Li J, Knobf M, Ye Z. Post-traumatic stress disorder, resilience and cancer-related fatigue in breast cancer: A moderated network analysis. European Journal Of Oncology Nursing 2025, 77: 102924. PMID: 40669268, DOI: 10.1016/j.ejon.2025.102924.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCancer-related fatigueBreast cancer survivorsCancer survivorsPost-traumatic stress disorderLower fatigue scoresStress disorderImpact of post-traumatic stress disorderJohnson-Neyman analysisCross-sectional analysisPost-traumatic stress disorder symptomsResilience-enhancing interventionsEffects of post-traumatic stress disorderFatigue scoresSelf-report measuresEmotional fatiguePsychological resilienceMental fatigueModerating pathwaysDebilitating symptomsSurvivorsPTSD symptomsInteraction effectsSymptom networksBreast cancerBreastThe interplay between sleep and cancer-related fatigue in breast cancer: A casual and computer-simulated network analysis
Li H, Xiong Y, Zhang Q, Lu Y, Chen Q, Wu S, Deng Y, Yang C, Knobf M, Ye Z. The interplay between sleep and cancer-related fatigue in breast cancer: A casual and computer-simulated network analysis. Asia-Pacific Journal Of Oncology Nursing 2025, 12: 100692. PMID: 40264549, PMCID: PMC12013401, DOI: 10.1016/j.apjon.2025.100692.Peer-Reviewed Original ResearchCitationsConceptsCancer-related fatiguePittsburgh Sleep Quality IndexSleep Quality IndexPredictors of cancer-related fatigueMultidimensional Fatigue Symptom Inventory-Short FormBreast cancerIntervention targetsOptimal intervention targetsQuality IndexDaytime dysfunctionImprove patientDysfunction itemsSleep qualitySymptom clustersSymptom interactionsSleep problemsInterventionGeneral fatigueFatiguePittsburghCore symptomsSymptomsBreastSleepSleep latencyDemoralization and sleep in breast cancer: A casual and computer-simulated network analysis
Li H, Xiong Y, Zhang Q, Lu Y, Chen Q, Wu S, Deng Y, Wu J, Knobf M, Ye Z. Demoralization and sleep in breast cancer: A casual and computer-simulated network analysis. European Journal Of Oncology Nursing 2025, 76: 102870. PMID: 40179533, DOI: 10.1016/j.ejon.2025.102870.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDemoralization ScaleBreast cancerLoss of emotional controlPittsburgh Sleep Quality IndexSleep Quality IndexSelf-reported dataDomains of sleepSense of hopelessnessDistress itemsTarget distressBridge symptomsSleep domainsSleep qualityDemoralizationDistressEmotional controlInterventionQuality IndexCore symptomsBreastSymptomsSleepItemsCancerPittsburghAssociation between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis
Chen F, Xiong Y, Li S, Deng Y, Zhang Q, Xiao Z, Knobf M, Ye Z. Association between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis. European Journal Of Oncology Nursing 2025, 74: 102822. PMID: 39893708, DOI: 10.1016/j.ejon.2025.102822.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
Clinical Trials
Current Trials
The Recovery in Stroke Using PAP Study (RISE-UP)
HIC ID2000024512RoleSub InvestigatorPrimary Completion Date01/31/2024Recruiting ParticipantsGenderBothAge18+ years
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