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Professor of Nursing
Biography
Dr. Knobf holds a master's degree from the Yale School of Nursing and a nursing doctorate from University of Pennsylvania. Dr. Knobf's clinical practice with women with breast cancer over the past three decades has been foundational to her clinical scholarship and program of research. Her initial research study on the phenomena of weight gain in women with breast cancer on adjuvant therapy, published in 1983, resulted from the observed distress of the women experiencing a change in weight. The concept of symptom distress became an integral component in her research.
Leadership in Oncology Nursing began early in her career, being elected to the Board of Directors of the Oncology Nursing Society in 1977. Dr. Knobf's contributions to nursing have been recognized through multiple awards including the Oncology Nursing Society Excellence in Breast Cancer Education award, the Yale School of Nursing Annie Goodrich Teaching award, American Cancer Society Bronze Medal, Distinguished Service award and was the American Cancer Society Professor of Oncology Nursing. Dr. Knobf's expertise has interdisciplinary recognition and she has been selected to participate in national forums related to breast cancer.
Last Updated on April 07, 2025.
Departments & Organizations
- Cancer Prevention and Control
- Nursing Website
- Obesity Research Working Group
- Yale Cancer Center
Research
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Overview
Medical Research Interests
Chemotherapy, Adjuvant
ORCID
0000-0001-6939-8262
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tish Knobf's published research.
Publications Timeline
A big-picture view of Tish Knobf's research output by year.
Research Interests
Research topics Tish Knobf is interested in exploring.
Shelli Feder, PhD, APRN, FNP (BC), ACHPN, FAAN
Lois S. Sadler, FAAN, RN, PhD
Prasanna Ananth, MD, MPH
Arietta Slade, PhD
Janene Batten, EdD, MLS
Karl Insogna, MD, FACP
57Publications
1,186Citations
Chemotherapy, Adjuvant
Publications
2025
Predictive Relationships Between Death Anxiety and Fear of Cancer Recurrence in Patients with Breast Cancer: A Cross-Lagged Panel Network Analysis
Chen F, Xiong Y, Li S, Zhang Q, Deng Y, Xiao Z, Knobf M, Ye Z. Predictive Relationships Between Death Anxiety and Fear of Cancer Recurrence in Patients with Breast Cancer: A Cross-Lagged Panel Network Analysis. Current Oncology 2025, 32: 685. PMID: 41440213, PMCID: PMC12731887, DOI: 10.3390/curroncol32120685.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsFear of cancer recurrenceCross-lagged panel analysisDeath anxietyBreast cancer patientsDeath-related cognitionsFear of Cancer Recurrence InventoryBreast cancerEmotion regulationCancer patientsTempler's Death Anxiety ScaleMental health problemsCross-lagged panel network analysisMonths post-dischargeCancer recurrenceDeath Anxiety ScaleSymptom nodesEarly-stage breast cancerEarly-stage breast cancer patientsPsychological distressAwareness of deathPost-dischargeLongitudinal relationshipBridge symptomsHealth problemsAdvanced cancerPsychometric evaluation of the Chinese version of Templer’s death anxiety scale using item response theory
Chen F, Deng Y, Li S, Zhang Q, Knobf M, Ye Z. Psychometric evaluation of the Chinese version of Templer’s death anxiety scale using item response theory. Measurement And Evaluations In Cancer Care 2025, 3: 100012. DOI: 10.1016/j.ymecc.2024.100012.Peer-Reviewed Original ResearchCitationsConceptsMokken scale analysisTempler's Death Anxiety ScaleEvaluate death anxietyDifferential item functioningDeath Anxiety ScaleDeath anxietyFear of deathItem response theoryChinese versionCancer patientsChinese cancer patientsAnxiety ScaleAcceptance of deathItem response theory analysisDifferential item functioning analysisGender differencesPsychometric evaluationItem functioningModerate difficultyAnxietyLocal independenceResponse theoryItemsIncreasing recognitionFearIdentifying gender-specific treatment targets for depression in cancer survivors: Evidence from NHANES
Deng Y, Chen F, Xiong Y, Li S, Zhang Q, Knobf M, Li J, Ye Z. Identifying gender-specific treatment targets for depression in cancer survivors: Evidence from NHANES. European Journal Of Oncology Nursing 2025, 80: 103030. PMID: 41260041, DOI: 10.1016/j.ejon.2025.103030.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyPatient Health Questionnaire-9Cancer survivorsDepressed moodIntervention targetsPotential intervention targetsAverage PHQ-9 scoreHealth and Nutrition Examination SurveyPHQ-9 scoresNutrition Examination SurveyCross-sectional studyOptimal intervention targetsPsychomotor changesOncology careExamination SurveyPsychosocial interventionsDepressive symptomsGender-specific treatmentSurvivorsConcentration difficultiesInterventionSuicidal ideationSymptom patternsDepressionMoodLife satisfaction moderates associations between resilience and postoperative symptom burden in oesophageal cancer: A moderated network analysis
Li S, Qin Y, Luo Y, Xie Y, Feng J, Li J, Knobf M, Li S, Ye Z. Life satisfaction moderates associations between resilience and postoperative symptom burden in oesophageal cancer: A moderated network analysis. European Journal Of Oncology Nursing 2025, 79: 103013. PMID: 41176905, DOI: 10.1016/j.ejon.2025.103013.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPostoperative symptom burdenJohnson-Neyman analysisSymptom burdenLife satisfactionOesophageal cancerConnor-Davidson Resilience ScaleSymptom Assessment ScaleCross-sectional designSupportive care strategiesSatisfaction with Life ScaleCross-sectional analysisHigher life satisfactionCare strategiesInverse associationResilience ScaleLife ScaleAssessment ScalePositive associationSatisfactionPersistent symptomsModeration analysisLate symptomsBurdenAssociationSymptomsA novel brain functional-structural hybrid analysis to explain the effect of a 6-month psychosocial intervention on resilience in breast cancer
Liang M, Zhou J, Chen P, Wu W, Song Y, Hu G, Hu Q, Sun Z, Yu Y, Liang Y, Molassiotis A, Knobf M, Ye Z. A novel brain functional-structural hybrid analysis to explain the effect of a 6-month psychosocial intervention on resilience in breast cancer. International Journal Of Clinical And Health Psychology 2025, 25: 100639. PMID: 41142584, PMCID: PMC12550284, DOI: 10.1016/j.ijchp.2025.100639.Peer-Reviewed Original ResearchConceptsPsychosocial interventionsResilience scoresRS-SC-10Mean resilience scoreBreast cancerDiffusion tensor imagingSupport interventionsTherapy interventionsResilience ScaleBehavioral interventionsBaseline resting-state functional magnetic resonance imagingInterventionRs-fMRIMagnetic resonance imagingResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingTreatment responseBreastResponse groupMR imagingResonance imagingCancerScoresBaselineTensor imagingDemoralization and dignity loss in breast cancer: A network analysis and computer simulation study
Xiong Y, Li H, Cai K, Yu M, Zhou J, Li J, Knobf M, Ye Z. Demoralization and dignity loss in breast cancer: A network analysis and computer simulation study. Asia-Pacific Journal Of Oncology Nursing 2025, 12: 100803. PMID: 41210322, PMCID: PMC12595355, DOI: 10.1016/j.apjon.2025.100803.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsDignity lossCancer survivorsFemale breast cancer survivorsPatient Dignity InventoryDemoralization Scale-IILoss of dignityPotential causal pathwaysEffective intervention strategiesIllness uncertaintyBridge symptomsCausal pathwaysSymptom targetsIntervention strategiesScale IIDemoralizationDistressBreast cancerDirect associationSurvivorsSymptom reductionSymptomsBreastDignityAssociationPreparing for a Child's End of Life: Parent Perspectives.
Ouyang N, Backman M, Knobf M, Snaman J, Baker J, Ananth P, Feder S. Preparing for a Child's End of Life: Parent Perspectives. 2025, 156 PMID: 40930538, DOI: 10.1542/peds.2025-072257.Peer-Reviewed Original ResearchCitationsAltmetricConceptsChild's endBereaved parentsChild's end of lifeChild deathsNon-Hispanic white mothersEOL decision-makingDevelopment of targeted interventionsEnd of lifeParental psychological symptomsQualitative descriptive studyEOL careDying childrenClinician communicationPeer supportSemistructured interviewsImpending deathClinician's difficultyPatient careThematic analysisDescriptive studyPsychological symptomsParents' perspectivesParental preparationWhite mothersCareContemporaneous and temporal symptom drivers during breast cancer chemotherapy: A prospective repeated-measures cohort study
Liang M, Li J, Xiang J, Zeng Y, Li S, Chen F, Pan Y, Zhong T, Chen L, Mei X, Zhou J, Xu M, Li J, Knobf M, Ye Z. Contemporaneous and temporal symptom drivers during breast cancer chemotherapy: A prospective repeated-measures cohort study. European Journal Of Oncology Nursing 2025, 78: 102944. PMID: 41004877, DOI: 10.1016/j.ejon.2025.102944.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProspective cohort studyExploratory factor analysisConfidence intervalsStage I-III breast cancerSymptom clustersMD Anderson Symptom InventoryI-III breast cancerProspective cohort study of patientsCohort study of patientsStable symptom clustersSymptom managementSymptom InventorySomatic symptomsNon-parametric bootstrappingBreast cancer chemotherapyIntervention targetsStudy of patientsSymptom effectsEarly interventionShortness of breathBreast cancerLoss of appetiteFactor analysisT1-T3Chemotherapy cyclesSelf-perceived burden, fear of progression and psychological flexibility in cervical cancer survivors: A moderated network analysis
Zhang Q, Chen F, Xiao Z, Li S, Deng Y, Knobf M, Li J, Ye Z. Self-perceived burden, fear of progression and psychological flexibility in cervical cancer survivors: A moderated network analysis. Asia-Pacific Journal Of Oncology Nursing 2025, 12: 100762. PMID: 40821968, PMCID: PMC12355130, DOI: 10.1016/j.apjon.2025.100762.Peer-Reviewed Original ResearchConceptsSelf-perceived burdenFear of progressionCervical cancer survivorsPatient psychological distressCancer survivorsPsychological flexibilitySPBS-CPFear of progression questionnaire-short formACT-based interventionModerate levelsCross-sectional studyJohnson-Neyman analysisLevels of PFCervical cancerPsychological distressOverall distressPsychological burdenSelf-perceivedMean scoreSurvivorsCancer patientsBurdenDistressFearAssociationFear of cancer recurrence and perceived pain in patients with breast cancer: A network analysis approach
Chen F, Deng Y, Li S, Zhang Q, Xiao Z, Knobf M, Ye Z. Fear of cancer recurrence and perceived pain in patients with breast cancer: A network analysis approach. Asia-Pacific Journal Of Oncology Nursing 2025, 12: 100763. PMID: 40821967, PMCID: PMC12355119, DOI: 10.1016/j.apjon.2025.100763.Peer-Reviewed Original ResearchCitationsConceptsFear of cancer recurrencePain catastrophizingFear of Cancer Recurrence InventoryBreast cancerTotal scorePain Catastrophizing ScaleCancer recurrenceCatastrophizing ScalePerceived PainPersonalized interventionsIntervention targetsEligible patientsSymptom activityInterventionPainBreastMulti-center trialScoresFearCancerCentral symptomsSymptomsAnalysis approachPatientsDirect relationship
Clinical Trials
Current Trials
The Recovery in Stroke Using PAP Study (RISE-UP)
HIC ID2000024512RoleSub InvestigatorPrimary Completion Date01/31/2024Recruiting ParticipantsGenderBothAge18+ years
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