Tanina Arab, PhD
she/her/hers
Managing Director, iPSC NeurocoreCards
About
Research
Publications
2025
Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD
Yang S, Wijegunawardana D, Sheth U, Veire A, Salgado J, Arab T, Agrawal M, Zhou J, Pereira J, Gendron T, Guo J. Aberrant splicing exonizes C9orf72 repeat expansion in ALS/FTD. Nature Neuroscience 2025, 28: 2034-2043. PMID: 40790269, PMCID: PMC12720984, DOI: 10.1038/s41593-025-02039-5.Peer-Reviewed Original ResearchThis study shows that faulty RNA splicing drives toxic protein production in ALS and frontotemporal dementia, identifying new therapeutic targets.
2024
Characterization of spinal cord tissue-derived extracellular vesicles in neuroinflammation
Jank L, Kesharwani A, Ryu T, Joshi D, Ladakis D, Smith M, Singh S, Arab T, Witwer K, Calabresi P, Na C, Bhargava P. Characterization of spinal cord tissue-derived extracellular vesicles in neuroinflammation. Journal Of Neuroinflammation 2024, 21: 154. PMID: 38851724, PMCID: PMC11162576, DOI: 10.1186/s12974-024-03147-y.Peer-Reviewed Original ResearchMinimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.
Welsh JA, Goberdhan DCI, O'Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks TAP, Erdbrügger U, Falcon-Perez JM, Fu QL, Hill AF, Lenassi M, Lim SK, Mahoney MG, Mohanty S, Möller A, Nieuwland R, Ochiya T, Sahoo S, Torrecilhas AC, Zheng L, Zijlstra A, Abuelreich S, Bagabas R, Bergese P, Bridges EM, Brucale M, Burger D, Carney RP, Cocucci E, Crescitelli R, Hanser E, Harris AL, Haughey NJ, Hendrix A, Ivanov AR, Jovanovic-Talisman T, Kruh-Garcia NA, Ku'ulei-Lyn Faustino V, Kyburz D, Lässer C, Lennon KM, Lötvall J, Maddox AL, Martens-Uzunova ES, Mizenko RR, Newman LA, Ridolfi A, Rohde E, Rojalin T, Rowland A, Saftics A, Sandau US, Saugstad JA, Shekari F, Swift S, Ter-Ovanesyan D, Tosar JP, Useckaite Z, Valle F, Varga Z, van der Pol E, van Herwijnen MJC, Wauben MHM, Wehman AM, Williams S, Zendrini A, Zimmerman AJ, MISEV Consortium, Théry C, Witwer KW. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles 2024, 13: e12404. PMID: 38326288, DOI: 10.1002/jev2.12404.Peer-Reviewed Original Research
2023
Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles (4/2023)
Huang Y, Arab T, Russell A, Mallick E, Nagaraj R, Gizzie E, Redding‐Ochoa J, Troncoso J, Pletnikova O, Turchinovich A, Routenberg D, Witwer K. Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles (4/2023). Interdisciplinary Medicine 2023, 1 DOI: 10.1002/inmd.12064.Peer-Reviewed Original ResearchToward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles
Huang Y, Arab T, Russell A, Mallick E, Nagaraj R, Gizzie E, Redding‐Ochoa J, Troncoso J, Pletnikova O, Turchinovich A, Routenberg D, Witwer K. Toward a human brain extracellular vesicle atlas: Characteristics of extracellular vesicles from different brain regions, including small RNA and protein profiles. Interdisciplinary Medicine 2023, 1: e20230016. PMID: 38089920, PMCID: PMC10712435, DOI: 10.1002/inmd.20230016.Peer-Reviewed Original ResearchExosomes, microvesicles, and other extracellular vesicles—a Keystone Symposia report
Cable J, Witwer K, Coffey R, Milosavljevic A, von Lersner A, Jimenez L, Pucci F, Barr M, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill A, Levy E, Hantak M, Crewe C, Aikawa E, Adamczyk A, Zanotto T, Ostrowski M, Arab T, Rabe D, Sheikh A, da Silva D, Jones J, Okeoma C, Gaborski T, Zhang Q, Gololobova O. Exosomes, microvesicles, and other extracellular vesicles—a Keystone Symposia report. Annals Of The New York Academy Of Sciences 2023, 1523: 24-37. PMID: 36961472, PMCID: PMC10715677, DOI: 10.1111/nyas.14974.Peer-Reviewed Original Research
2022
Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers
Huang Y, Driedonks T, Cheng L, Rajapaksha H, Routenberg D, Nagaraj R, Redding J, Arab T, Powell B, Pletniková O, Troncoso J, Zheng L, Hill A, Mahairaki V, Witwer K. Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers. Journal Of Alzheimer’s Disease 2022, 90: 1057-1072. PMID: 36213994, PMCID: PMC9741741, DOI: 10.3233/jad-220322.Peer-Reviewed Original ResearchRelationships of APOE Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD
Huang Y, Driedonks T, Cheng L, Rajapaksha H, Turchinovich A, Routenberg D, Nagaraj R, Redding-Ochoa J, Arab T, Powell B, Pletnikova O, Troncoso J, Zheng L, Hill A, Mahairaki V, Witwer K. Relationships of APOE Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD. Neurology Genetics 2022, 8: e200026. PMID: 36405397, PMCID: PMC9667865, DOI: 10.1212/nxg.0000000000200026.Peer-Reviewed Original ResearchNeutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV
Zhu X, Hollinger K, Huang Y, Borjabad A, Kim B, Arab T, Thomas A, Moniruzzaman M, Lovell L, Turchinovich A, Witwer K, Volsky D, Haughey N, Slusher B. Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV. Neurobiology Of Disease 2022, 169: 105734. PMID: 35462006, PMCID: PMC9202342, DOI: 10.1016/j.nbd.2022.105734.Peer-Reviewed Original Research
2021
Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms
Arab T, Mallick E, Huang Y, Dong L, Liao Z, Zhao Z, Gololobova O, Smith B, Haughey N, Pienta K, Slusher B, Tarwater P, Tosar J, Zivkovic A, Vreeland W, Paulaitis M, Witwer K. Characterization of extracellular vesicles and synthetic nanoparticles with four orthogonal single‐particle analysis platforms. Journal Of Extracellular Vesicles 2021, 10: e12079. PMID: 33850608, PMCID: PMC8023330, DOI: 10.1002/jev2.12079.Peer-Reviewed Original Research
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