Slav Bagriantsev, PhD
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Cellular & Molecular Physiology
Sterling Hall of Medicine, B-Wing, 333 Cedar St
New Haven, CT 06510
United States
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Professor
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Cellular & Molecular Physiology
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Education & Training
- Postdoc
- University of California San Francisco (2012)
- PhD
- University of Illinois at Chicago (2007)
Research
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Overview
Medical Research Interests
Anseriformes; Biochemistry; Biophysics; Ducks; Electrophysiology; Ion Channels; Mechanoreceptors; Neurosciences; Pacinian Corpuscles; Potassium Channels; Sensory Receptor Cells; Thermoreceptors; Transient Receptor Potential Channels; Trigeminal Ganglion; Voltage-Gated Sodium Channels
ORCID
0000-0002-6661-3403- View Lab Website
The Slav Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Slav Bagriantsev's published research.
Publications Timeline
A big-picture view of Slav Bagriantsev's research output by year.
Research Interests
Research topics Slav Bagriantsev is interested in exploring.
Elena Gracheva, PhD
Viktor Feketa
Patrick Gallagher, MD, BS
Song Pang
C. Shan Xu, PhD
Mai Oda
40Publications
1,039Citations
Ion Channels
Mechanoreceptors
Ducks
Trigeminal Ganglion
Pacinian Corpuscles
Sensory Receptor Cells
Publications
Featured Publications
The inner core enables transient touch detection in the Pacinian corpuscle
Ziolkowski L, Nikolaev Y, Chikamoto A, Oda M, Feketa V, Monedero-Alonso D, Ardasheva S, Bae S, Xu C, Pang S, Gracheva E, Bagriantsev S. The inner core enables transient touch detection in the Pacinian corpuscle. Science Advances 2025, 11: eadt4837. PMID: 40009676, PMCID: PMC11864184, DOI: 10.1126/sciadv.adt4837.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsSuppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels
Junkins M, Feng N, Merriman D, Bagriantsev S, Gracheva E. Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels. Science 2024, 386: 1048-1055. PMID: 39607925, PMCID: PMC11853976, DOI: 10.1126/science.adp8358.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
Nikolaev Y, Ziolkowski L, Pang S, Li W, Feketa V, Xu C, Gracheva E, Bagriantsev S. 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Science Advances 2023, 9: eadi4147. PMID: 37703368, PMCID: PMC10499330, DOI: 10.1126/sciadv.adi4147.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMechanotransduction events at the physiological site of touch detection
Ziolkowski L, Gracheva E, Bagriantsev S. Mechanotransduction events at the physiological site of touch detection. ELife 2023, 12: e84179. PMID: 36607222, PMCID: PMC9833821, DOI: 10.7554/elife.84179.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsLamellar cells in Pacinian and Meissner corpuscles are touch sensors
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6: eabe6393. PMID: 33328243, PMCID: PMC7744075, DOI: 10.1126/sciadv.abe6393.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLamellar cellsR-type voltage-gated calcium channelsMeissner corpusclesAction potentialsChannel-dependent action potentialsPacinian corpusclesVoltage-gated calcium channelsSensory afferent neuronsNon-neuronal cellsBill skinAfferent neuronsNeuronal afferentsCalcium channelsElectrophysiological recordingsTactile stimuliCorpusclesIon channelsCellsSkinFirst evidenceTactile organsAfferentsNeuronsPiezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors
Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17547-17555. PMID: 31413193, PMCID: PMC6717272, DOI: 10.1073/pnas.1910213116.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsA Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTrigeminal ganglionPiezo2 ion channelsExpression of moleculesExpression of factorsPiezo2 expressionSomatosensory neuronsNeuronal subtypesSomatosensory systemSuch neuronsSpecialist birdsBird speciesMolecular variationFamily AnatidaeForaging behaviorTactile specializationNeuronsMechanoreceptorsSpecies analysisGangliaGeneral roleBehavioral phenotypesIon channelsGeneral mechanismTactile specialistsFunction of mechanoreceptorsA hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. ELife 2019, 8: e44003. PMID: 30628892, PMCID: PMC6349400, DOI: 10.7554/elife.44003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPiezo channelsLining inner helixIon channelsMechanosensitive Piezo channelsInner pore helixImportance of inactivationMouse Piezo1Disease-causing mutationsHydrophobic gateInner helixPore helixPhysiological processesMechanism of inactivationStimulation triggersInactivationInactivation gatePiezo1Normal functionHelixHydrophobic barrierFast inactivationPhysical constrictionSecondary gateRate of inactivationMajor determinantFunctional evidence for early origin of tactile acuity in the vertebrate somatosensory system
Tan K, Hillgen-Santa L, Graham M, Li Y, Liu X, Pang S, Gracheva E, Bagriantsev S. Functional evidence for early origin of tactile acuity in the vertebrate somatosensory system. Current Biology 2025, 35: 4754-4764.e6. PMID: 40945511, PMCID: PMC12478595, DOI: 10.1016/j.cub.2025.08.035.Peer-Reviewed Original ResearchCitationsAltmetricHypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
Mohr S, Dai Pra R, Platt M, Feketa V, Shanabrough M, Varela L, Kristant A, Cao H, Merriman D, Horvath T, Bagriantsev S, Gracheva E. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nature Communications 2024, 15: 5803. PMID: 38987241, PMCID: PMC11236985, DOI: 10.1038/s41467-024-49996-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHypothalamic feeding centersHormone deficiencyHypothalamic arcuate nucleus neuronsArcuate nucleus neuronsThyroid hormone deficiencyFeeding centerEffects of ghrelinAnorexigenic effectNucleus neuronsPhysiological anorexiaThyroid hormonesNormal physiological functionsGround squirrelsInterbout arousalAnorexiaThirteen-lined ground squirrelsProlonged periodReduced sensitivityPhysiological functionsDeficiency
Academic Achievements & Community Involvement
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Activities
activity Yale Science Outreach
Public ServiceCoordinatorDetailsYale S.C.H.O.L.A.R. program
Honors
honor CAREER Award
05/15/2015National AwardNational Science FoundationDetailsUnited Stateshonor Scientist Development Grant
01/01/2014National AwardAmerican Heart AssociationDetailsUnited Stateshonor Post-doctoral Fellowship
01/01/2009National AwardGenentech Foundation and the Life Sciences Research FoundationDetailsUnited Stateshonor Pre-doctoral Fellowship
01/01/2006National AwardAmerican Heart AssociationDetailsUnited States
News
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News
- April 01, 2026
Bagriantsev Selected for Javits Neuroscience Investigator Award
- April 16, 2025
Rodriguez & Favuzzi, and Bagriantsev & Machta Honored With 2025 Kavli Innovative Teams Awards
- February 20, 2025Source: Neurophysiology of resting rodents could hold secrets to suspended animation
Yale Physiology researchers discover how hibernating squirrels conquer thirst
- November 28, 2024Source: Popular Science
How hibernating squirrels go more than six months without water—and don’t get thirsty
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Mailing Address
Cellular & Molecular Physiology
Sterling Hall of Medicine, B-Wing, 333 Cedar St
New Haven, CT 06510
United States
Locations
Sterling Hall of Medicine, B-Wing
Lab
333 Cedar Street, Ste Room 146
New Haven, CT 06510
Sterling Hall of Medicine, B-Wing
Academic Office
333 Cedar Street, Ste Room 142
New Haven, CT 06510