Susan Compton, PhD
Senior Research Scientist in Comparative MedicineDownloadHi-Res Photo
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Appointments
Comparative Medicine
Primary
Additional Titles
Director, Molecular and Serological Diagnostics, Comparative Medicine
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Additional Titles
Director, Molecular and Serological Diagnostics, Comparative Medicine
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Additional Titles
Director, Molecular and Serological Diagnostics, Comparative Medicine
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
About
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Titles
Senior Research Scientist in Comparative Medicine
Director, Molecular and Serological Diagnostics, Comparative Medicine
Biography
The Compton laboratory studies the diagnosis, pathogenesis, transmission and prevention of viral infections of rodents.
Last Updated on December 10, 2024.
Appointments
Comparative Medicine
Senior Research ScientistPrimary
Other Departments & Organizations
- All Institutions
- Comparative Medicine
- Molecular Virology
- Virology Laboratories
Education & Training
- Postdoctoral Fellow
- University of Colorado (1990)
- PhD
- Uniformed Services University (1988)
- BS
- Bucknell University, Biology (1981)
Research
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Overview
Medical Research Interests
Bacterial Infections and Mycoses; Coronavirus; DNA Virus Infections; Ectoparasitic Infestations; Norovirus; Organisms; Parvovirus; RNA Virus Infections; Rodent Diseases; Viral Zoonoses; Virus Diseases; Zoonoses
Public Health Interests
Viruses; Zoonotic Diseases; Infectious Diseases; Cross-Species Transmission; Disease Transmission
ORCID
0000-0001-9644-1561- View Lab Website
Virology Diagnostic Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Susan Compton's published research.
Publications Timeline
A big-picture view of Susan Compton's research output by year.
Research Interests
Research topics Susan Compton is interested in exploring.
Caroline Zeiss, DACVP, DACLAM
Brent Vander Wyk, PhD
Heather Allore, PhD
Craig B. Wilen, MD, PhD
James Macy Jr, DVM
Madison Strine, PhD
26Publications
280Citations
Rodent Diseases
Parvovirus
Coronavirus
Virus Diseases
Publications
2025
The coronaviral landscape across diverse mammalian species in the Northeastern United States
Ibemgbo S, Compton S, Breban M, Redmond S, Grubaugh N, Linske M, Williams S, Zyskowski K, Watkins-Colwell G, Lewis J, Syracuse M, Risatti G, Tanner W, Zeiss C. The coronaviral landscape across diverse mammalian species in the Northeastern United States. Scientific Reports 2025, 16: 2942. PMID: 41422148, PMCID: PMC12830656, DOI: 10.1038/s41598-025-32849-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWhite-footed miceEvolution of SARS-CoV-2In vivo infectionHCoV-OC43Animal viromesDiverse mammalian speciesMammalian host rangeHost rangeSARS-CoV-2Fecal swabsAncestral strainInterspecies transmissionMammalian speciesStool specimensInfection studiesHuman infectionsNortheastern United StatesLaboratory infection studiesSpeciesOmicron variantIntraspecies transmissionDomestic animalsOral swabsDetection of severe acute respiratory syndrome coronavirus 2Viral RNA shedding
2023
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Wei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMouse hepatitis virusReceptor expressionTherapeutic targetMERS-CoVMajor SARS-CoV-2 variantsPrimary human airwaySARS-CoV-2 variantsNovel therapeutic targetViral receptor expressionSARS-CoV-2Histone methyltransferase KMT2DIntestinal epithelial cellsCoronavirus SusceptibilityDiverse coronavirusesHistone demethylase KDM6ADPP4 expressionCoronavirus receptorsHost determinantsHepatitis virusHuman airwaysSARS-CoVSmall molecule inhibitionViral entryPotential drug targetsViral receptors
2022
Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data
Mullin S, Vander Wyk B, Asher JL, Compton SR, Allore HG, Zeiss CJ. Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data. PNAS Nexus 2022, 1: pgac096. PMID: 35799833, PMCID: PMC9254158, DOI: 10.1093/pnasnexus/pgac096.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSARS-CoV-2 transmissionNatural infectionDuration of immunitySARS-CoV-2 pandemicAnimal model dataEndemic stateHeterologous vaccinationMedian timeCoronaviral diseaseDeterministic compartmental modelNatural immunityLow prevalenceCoronaviral infectionVaccinationViral transmissionInfectionTransmissible variantsImmunityEndemic patternReinfection dataNatural exposureReinfectionEndemic stabilityVariable durationAnimals
2021
Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission
Zeiss CJ, Asher JL, Vander Wyk B, Allore HG, Compton SR. Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission. PLOS ONE 2021, 16: e0260038. PMID: 34813610, PMCID: PMC8610237, DOI: 10.1371/journal.pone.0260038.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsViral sheddingSialodacryoadenitis virusSARS-CoV-2Prior natural infectionSARS-CoV-2 propagationSeropositive animalsLow-level sheddingNaive recipient ratsCOVID-19Cycle threshold valuesDirect contact exposureSeroconversion ratesReinfected animalsRecipient ratsImmune protectionHigh riskNaive animalsSusceptible individualsInitial infectionGlobal immunityExposure paradigmRat coronavirusNatural infectionInfectionRatsOverview of Coronaviruses in Veterinary Medicine.
Compton SR. Overview of Coronaviruses in Veterinary Medicine. Journal Of The American Association For Laboratory Animal Science 2021, 71: 333-341. PMID: 34412731, PMCID: PMC8594256, DOI: 10.30802/aalas-cm-21-000007.Peer-Reviewed Original ResearchCitationsAltmetricAnimal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis
Zeiss CJ, Compton S, Veenhuis RT. Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis. ILAR Journal 2021, 62: ilab007-. PMID: 33836527, PMCID: PMC8083356, DOI: 10.1093/ilar/ilab007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSARS-CoV-2SARS-CoVViral sheddingImmune responseSpontaneous modelAnimal modelsDisease pathogenesisSARS-CoV-2 infectionCOVID-19Severe acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusChimeric SARS-CoVRole of comorbiditiesCoronavirus disease 2019 (COVID-19) pandemicShort-term immune responseWild-type miceSeverity of diseaseOrgan-specific pathologySARS-CoV-2 virusDisease 2019 pandemicAfrican green monkeysTest therapeuticsVaccine approachesNonfatal diseaseTissue involvement
2020
Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats.
Sarfaty AE, Compton SR, Smith PC, Zeiss CJ. Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats. Journal Of The American Association For Laboratory Animal Science 2020, 70: 390-395. PMID: 32736665, PMCID: PMC7446636, DOI: 10.30802/aalas-cm-20-000015.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsPCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.
Compton SR. PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring. Journal Of The American Association For Laboratory Animal Science 2020, 59: 458-468. PMID: 32580820, PMCID: PMC7479767, DOI: 10.30802/aalas-jaalas-20-000008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2019
Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta)
Sarfaty AE, Fulbright RK, Compton SR, Asher JL, Zeiss CJ. Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta). Journal Of Medical Primatology 2019, 49: 103-106. PMID: 31789460, DOI: 10.1111/jmp.12453.Peer-Reviewed Original ResearchChapter 13 Viral Disease
Macy J, Compton S. Chapter 13 Viral Disease. 2019, 541-568. PMCID: PMC7153344, DOI: 10.1016/b978-0-12-814338-4.00013-1.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity American Association for Laboratory Science
2000 - 2024Journal ServiceAssociate Editor
Honors
honor Pravin N. Bhatt Scientific Investigator Award
10/12/2019National AwardAmerican Association for Laboratory Animal ScienceDetailsUnited Stateshonor Honarary Diplomate
05/01/2018National AwardAmerican College of Laboratory Animal MedicineDetailsUnited States
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Mailing Address
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States