Sung Hoon Lee
Associate Research ScientistAbout
Research
Publications
2025
Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway
Lee S, Kang T, Shang X, Levchenko A. Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway. Cell Systems 2025, 16: 101321. PMID: 40541183, PMCID: PMC12276906, DOI: 10.1016/j.cels.2025.101321.Peer-Reviewed Original ResearchSequential activation of SrcPaper's transparent peer review processTransparent peer review processActivation of SrcPathway levelMultiple phenotypesPhenotypic outcomesRearrangement of cellsPathway componentsPathway organizationNotch signalingPhysiological processesCell contactSequential activationPathwayVascular endothelial growth factor signalingSignal inputVascular endothelial growth factorDiverse time scalesDynamic decoderCoordinated controlVEGF signalingGrowth factorSignalElevated levels
2023
SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces.
Lee S, Yousafzai M, Mohler K, Yadav V, Amiri S, Szuszkiewicz J, Levchenko A, Rinehart J, Murrell M. SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces. Molecular Biology Of The Cell 2023, 34: ar122. PMID: 37672340, PMCID: PMC10846615, DOI: 10.1091/mbc.e23-03-0103.Peer-Reviewed Original Research
2022
A molecular clock controls periodically driven cell migration in confined spaces
Lee SH, Hou JC, Hamidzadeh A, Yousafzai MS, Ajeti V, Chang H, Odde DJ, Murrell M, Levchenko A. A molecular clock controls periodically driven cell migration in confined spaces. Cell Systems 2022, 13: 514-529.e10. PMID: 35679858, DOI: 10.1016/j.cels.2022.05.005.Peer-Reviewed Original ResearchConceptsCell migrationSmall GTPase RhoAFaster cell migrationNegative feedback loopExchange factorMolecular clockGEF-H1RhoA guanineGTPase RhoAMicrotubule dynamicsMolecular mechanismsClock controlCell spreadExtracellular matrixIntracellular CaTissue reorganizationFeedback loopMigrationRhoAAbundanceGuanineBetter understanding
2019
3D Analysis of Multi-cellular Responses to Chemoattractant Gradients.
Kang TY, Ellison D, Lee SH, Ewald AJ, Levchenko A. 3D Analysis of Multi-cellular Responses to Chemoattractant Gradients. Journal Of Visualized Experiments 2019 PMID: 31180367, DOI: 10.3791/59226.Peer-Reviewed Original Research
2017
Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations
Park J, Holmes WR, Lee SH, Kim HN, Kim DH, Kwak MK, Wang CJ, Edelstein-Keshet L, Levchenko A. Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e5750-e5759. PMID: 28655842, PMCID: PMC5514712, DOI: 10.1073/pnas.1700054114.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorCell MovementCell PolarityCell ShapeDisease ProgressionExtracellular MatrixFeedback, PhysiologicalGene Expression Regulation, NeoplasticHumansMelanomaModels, TheoreticalMutationNeoplasm InvasivenessOscillometryPhenotyperho GTP-Binding ProteinsSignal TransductionSkin NeoplasmsConceptsMechanochemical feedbackRho family small GTPasesDirectional cell migrationDiverse cell typesDiverse cell populationsUnderlying regulatory mechanismsPhenotypic plasticityCell polaritySmall GTPasesRegulatory mechanismsEnvironmental perturbationsPolarity patternCell polarizationPopulation variabilityCell migrationCell spreadCell typesExtracellular matrixMechanistic understandingCell contactCell populationsPhysiological conditionsMelanoma cellsDynamic patternsGTPases
2016
Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses
Noren DP, Chou WH, Lee SH, Qutub AA, Warmflash A, Wagner DS, Popel AS, Levchenko A. Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses. Science Signaling 2016, 9: ra20. PMID: 26905425, PMCID: PMC5301990, DOI: 10.1126/scisignal.aad3188.Peer-Reviewed Original ResearchConceptsTranscription factor NFATDifferent cellular behaviorsDistinct functional responsesEndothelial cellsExtracellular stimuliSingle extracellular stimulusIsogenic cellsCellular behaviorCell migrationCell proliferationVEGF gradientsFunctional responseGrowth factorAmount of VEGFCellsProliferationZebrafishVEGFFurther analysisNFATMigrationSignal inputCell responsesDiverse behaviorsMLCKCell–cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis
Ellison D, Mugler A, Brennan MD, Lee SH, Huebner RJ, Shamir ER, Woo LA, Kim J, Amar P, Nemenman I, Ewald AJ, Levchenko A. Cell–cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e679-e688. PMID: 26792522, PMCID: PMC4760786, DOI: 10.1073/pnas.1516503113.Peer-Reviewed Original ResearchConceptsCell-cell communicationCollective cell responseEpidermal growth factor (EGF) gradientsCell-cell interactionsGradient sensingMammary epithelial cellsSignaling inputsSingle-cell sensitivityGrowth factor gradientsIntegrative analysisIntercellular communicationCell ensemblesChemotactic cuesMulticellular sensingFunctional experimentsFactor gradientsSingle cellsGap junctionsEpithelial cellsTissue formEffective sizeExogenous cuesIntracellular storesCellsComplex changes
2014
Repetitive Cleavage of Elastomeric Membrane via Controlled Interfacial Fracture
Kim J, Choi Y, Kim M, Um H, Lee S, Kim P, Suh K. Repetitive Cleavage of Elastomeric Membrane via Controlled Interfacial Fracture. ACS Applied Materials & Interfaces 2014, 6: 11734-11740. PMID: 24988493, DOI: 10.1021/am502477w.Peer-Reviewed Original ResearchOne-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays.
Eun Chung S, Kim J, Yoon Oh D, Song Y, Hoon Lee S, Min S, Kwon S. One-step pipetting and assembly of encoded chemical-laden microparticles for high-throughput multiplexed bioassays. Nat Commun 2014, 5: 3468. PMID: 24632848, DOI: 10.1038/ncomms4468.Peer-Reviewed Original Research
2012
Lithographically encoded polymer microtaggant using high-capacity and error-correctable QR code for anti-counterfeiting of drugs.
Han S, Bae HJ, Kim J, Shin S, Choi SE, Lee SH, Kwon S, Park W. Lithographically encoded polymer microtaggant using high-capacity and error-correctable QR code for anti-counterfeiting of drugs. Adv Mater 2012, 24: 5924-9. PMID: 22930454, DOI: 10.1002/adma.201201486.Peer-Reviewed Original Research