Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsStephanie Groman, PhD
Assistant Professor Adjunct of PsychiatryAbout
Copy Link
Titles
Assistant Professor Adjunct of Psychiatry
Biography
Dr. Groman's research program is aimed at understanding the neurobiology and neurodevelopmental mechanisms of decision making to identify biological targets that could be manipulated to prevent and treat mental illness. She received her Ph.D. in 2013 from the Department of Psychology at the University of California, Los Angeles where she trained under Dr. J. David Jentsch and Dr. Edythe London. Her work integrated neuroimaging, behavioral, pharmacological and ex vivo approaches to provide the first evidence that chronic exposure to methamphetamine resulted in the neural and behavioral alterations that had been previously observed in substance-dependent individuals. Her work was recognized by several awards, including a predoctoral NIH NRSA fellowship, the UCLA Brain Research Institute Award and the Joseph A. Gengerelli Distinguished Dissertation Award. She accepted a post-doctoral position in the Department of Psychiatry at Yale University where she trained under Dr. Jane Taylor in studies investigating the biobehavioral mechanisms of addiction.
In 2016 Dr. Groman was promoted to Associate Research Scientists at Yale University where her work has focused on understanding the neural circuits of decision-making and addiction. She integrates computational approaches with neuroimaging, proteomics, and drug self-administration in rodents to provide a translational platform for understanding the biological and neurodevelopmental mechanisms of addiction vulnerability. The Groman Lab will be moving to the Department of Neuroscience at the University of Minnesota in January 2021 and will be a part of the Medical Discovery Team on Addiction.
Education & Training
- PhD
- University of California Los Angeles (2013)
- MA
- University of California, Los Angeles, Psychology (2012)
- BSc
- University of California, Los Angeles, Psychology (2005)
Research
Copy Link
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0002-5231-0612
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Jane Rebecca Taylor, PhD
Krista Fowles
Praveen Suthaharan
Ralph DiLeone, PhD
Summer L Thompson, PhD, MS
Daniel Holden
Decision Making
Reinforcement, Psychology
Positron-Emission Tomography
Methamphetamine
Cognition
Magnetic Resonance Imaging
Publications
2025
The mesocorticolimbic system in stimulant use disorder
London E, Groman S, Leyton M, de Wit H. The mesocorticolimbic system in stimulant use disorder. Molecular Psychiatry 2025, 1-14. PMID: 40926091, DOI: 10.1038/s41380-025-03148-0.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStimulant use disorderStimulant useUse disorderMesocorticolimbic systemBehavioral effectsEffects of stimulant drugsAddiction symptomsNeurotransmitter systemsStimulant drugsIndividual differencesNeural mechanismsDiscover treatmentsEarly interventionAddictionDisordersMesocorticolimbicLaboratory animalsDopamineNeurotransmitterStimulationSymptomsEvidenceLesser extentGlutamateUseDisruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats
LaRocco K, Villiamma P, Hill J, Russell M, DiLeone R, Groman S. Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats. Biological Psychiatry Global Open Science 2025, 5: 100450. PMID: 40083740, PMCID: PMC11904576, DOI: 10.1016/j.bpsgos.2025.100450.Peer-Reviewed Original ResearchCitationsConceptsAddiction-relevant behaviorsBiobehavioral mechanismsReward-guided decision-makingProbabilistic reversal-learning taskSaccharin fading procedureOxycodone self-administrationFemale Long-Evans ratsReversal-learning taskPathology of addictionFemale ratsTest of motivationDrug useLong-Evans ratsSuboptimal decision-makingOpioid use disorderSelf-AdministrationAddiction susceptibilityFading procedureEvans ratsSex differencesProblematic opioid useAdaptive decision-making processesDecision-making functionsAddictionDecision-making data
2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
2022
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats
Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology 2022, 48: 489-497. PMID: 36100654, PMCID: PMC9852230, DOI: 10.1038/s41386-022-01441-y.Peer-Reviewed Original ResearchCitationsAdolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats
Villiamma P, Casby J, Groman SM. Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology 2022, 239: 2885-2901. PMID: 35705734, PMCID: PMC10332493, DOI: 10.1007/s00213-022-06174-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCocaine-taking behaviorReversal-learning performanceDecision-making functionsReversal-learning taskReinforcement learning modelIndividual differencesAdolescent developmentFemale Long-Evans ratsRewarded outcomesDevelopmental trajectoriesNeurobiological mechanismsAdolescent trajectoriesAge-related changesGreater cocaineBiobehavioral mechanismsNeural adaptationLong-Evans ratsPredictive relationshipAddiction susceptibilityAdolescenceChoice behaviorAdulthoodDecision-making trajectoriesMental illnessChoice dataImaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)
Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman S, Carson RE. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3679-3691. PMID: 35633376, PMCID: PMC9826644, DOI: 10.1007/s00259-022-05825-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographySynaptic densityFetal brainThird trimesterEmission tomographyBrain developmentGravid rhesus monkeysPost-mortem brain tissueEarly neonatal periodNonhuman primate brainLate gestational periodSubset of subjectsPostnatal brain developmentPost-mortem samplesGestational ageNeonatal periodPregnant monkeysSynapse numberGestational periodPrimary motorPrimate brainBrain growthSubcortical regionsBrain tissueCortical regionsMicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV
Young JW, Barback CV, Stolz LA, Groman SM, Vera DR, Hoh C, Kotta KK, Minassian A, Powell SB, Brody AL. MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Research Neuroimaging 2022, 321: 111445. PMID: 35101828, DOI: 10.1016/j.pscychresns.2022.111445.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGp120 transgenic miceWildtype miceTransgenic miceCognitive deficits persistElevated inflammatory profilesPositron emission tomography studyEmission tomography studiesElevated neuroinflammationNeuroinflammatory profileInflammatory profileInflammatory insultVentral striataHIV envelopeLipopolysaccharide treatmentHIV entryMouse modelHIVBehavioral abnormalitiesDeficits persistMiceTomography studyVivo evidenceEnvelope glycoproteinPLWHNeuroinflammation
2021
Reinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudyParanoia and belief updating during the COVID-19 crisis
Suthaharan P, Reed EJ, Leptourgos P, Kenney JG, Uddenberg S, Mathys CD, Litman L, Robinson J, Moss AJ, Taylor JR, Groman SM, Corlett PR. Paranoia and belief updating during the COVID-19 crisis. Nature Human Behaviour 2021, 5: 1190-1202. PMID: 34316049, PMCID: PMC8458246, DOI: 10.1038/s41562-021-01176-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsUnlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex
Groman SM, Lee D, Taylor JR. Unlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex. Behavioral Neuroscience 2021, 135: 120-128. PMID: 34060870, PMCID: PMC8201418, DOI: 10.1037/bne0000414.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOrbitofrontal cortexReinforcement-learning mechanismsDecision-making impairmentsDiverse clinical populationsDecision-making differsNeurocomputational approachOFC dysfunctionNeuroscience techniquesBiobehavioral disordersBehavioral paradigmsClinical populationsBiobehavioral mechanismsAddiction pathologyComputational differencesReinforcement-learning algorithms
Get In Touch
Copy Link