Sounok Sen, MD
Assistant ProfessorCards
About
Research
Publications
2025
Health Care Resource Use and Economic Burden in Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy and Atrial Fibrillation.
Stendahl J, Sen S, Butzner M, Papademetriou E, Potluri R, Liu X, Jacoby D, Freeman J. Health Care Resource Use and Economic Burden in Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy and Atrial Fibrillation. Journal Of The American Heart Association 2025, 14: e038755. PMID: 40847492, DOI: 10.1161/jaha.124.038755.Peer-Reviewed Original ResearchConceptsSymptomatic obstructive hypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathyHealth care resource useCare resource useHealth care costsAtrial fibrillationTotal health care costsIncident AFCare costsHypertrophic cardiomyopathyRetrospective analysisSeptal reduction therapyGreater health care costsRetrospective analysis of claims dataDiagnosis of AFImpact of AFResource useAnalysis of claims dataAdult patientsReduction therapyPatient managementUrgent carePatientsClaims dataCardiomyopathyIdentification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning
Sangha V, Dhingra L, Aminorroaya A, Croon P, Sikand N, Sen S, Martinez M, Maron M, Krumholz H, Asselbergs F, Oikonomou E, Khera R. Identification of hypertrophic cardiomyopathy on electrocardiographic images with deep learning. Nature Cardiovascular Research 2025, 4: 991-1000. PMID: 40696040, DOI: 10.1038/s44161-025-00685-3.Peer-Reviewed Original ResearchCurrent management of hypertrophic cardiomyopathy
Sikand N, Stendahl J, Sen S, Lampert R, Day S. Current management of hypertrophic cardiomyopathy. The BMJ 2025, 389: e077274. PMID: 40425241, DOI: 10.1136/bmj-2023-077274.Peer-Reviewed Original ResearchConceptsOutflow tract gradientObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyAtrial fibrillationLeft ventricular outflow tract gradientNon-obstructive hypertrophic cardiomyopathyManagement of hypertrophic cardiomyopathyRisk of sudden deathCardiac sarcomere genesImplantable cardioverter-defibrillator implantationSeptal reduction therapyNon-obstructive diseaseSymptomatic atrial fibrillationCardiac myosin inhibitorLeft ventricular hypertrophySurgical treatment optionsCardioverter-defibrillator implantationAdvanced heart failureStructural heart conditionsArrhythmic riskCardiac transplantationImprove patient outcomesRhythm controlMedical therapyVentricular hypertrophyCirculating Tissue Specific Extracellular Vesicles for Noninvasive Monitoring of Acute Cellular Rejection in Clinical Heart Transplantation
Korutla L, Hu R, Liu Y, Romano C, Habertheuer A, Abedi P, Wang H, Molugu S, Rostami S, Naji A, Nuqali A, Beasley M, Maulion C, Hahn S, Ahmad T, Wang Z, Sen S, Vallabhajosyula P. Circulating Tissue Specific Extracellular Vesicles for Noninvasive Monitoring of Acute Cellular Rejection in Clinical Heart Transplantation. Transplantation 2025, 109: 1540-1550. PMID: 40238644, DOI: 10.1097/tp.0000000000005369.Peer-Reviewed Original ResearchModerate acute cellular rejectionAcute cellular rejectionT cellsHeart transplantationSmall extracellular vesiclesCellular rejectionAntibody-mediated rejectionEndomyocardial biopsy samplesHeart transplant patientsWilcoxon rank sum testExtracellular vesiclesClinical heart transplantationRank sum testCardiac allograftsExternal validation studyCTnT proteinTransplant patientsPostoperative dayDiagnostic accuracyBiopsy samplesSuccessful treatmentCargo of small extracellular vesiclesTransplantationPatientsDiagnostic potentialElectronic health record nudges to optimize guideline-directed medical therapy for heart failure
Fuery M, Clark K, Sikand N, Tabtabai S, Sen S, Wilson F, Desai N, Ahmad T, Samsky M. Electronic health record nudges to optimize guideline-directed medical therapy for heart failure. Heart Failure Reviews 2025, 30: 771-776. PMID: 40106122, DOI: 10.1007/s10741-025-10503-4.Peer-Reviewed Original ResearchConceptsElectronic health recordsClinical decision supportGuideline-directed medical therapyPotential of electronic health recordsElectronic health record systemsDiverse healthcare settingsGDMT adherenceCare qualityClinician workflowHealth recordsAlert contentHF careHealthcare settingsPatient careInformed treatment decisionsTargeted alertingQuality gapEnhanced usabilityImprove heart failureHeart failureDecision supportReal-timeCareTreatment decisionsAlerting strategy
2024
A Multicenter Evaluation of the Impact of Therapies on Deep Learning-Based Electrocardiographic Hypertrophic Cardiomyopathy Markers
Dhingra L, Sangha V, Aminorroaya A, Bryde R, Gaballa A, Ali A, Mehra N, Krumholz H, Sen S, Kramer C, Martinez M, Desai M, Oikonomou E, Khera R. A Multicenter Evaluation of the Impact of Therapies on Deep Learning-Based Electrocardiographic Hypertrophic Cardiomyopathy Markers. The American Journal Of Cardiology 2024, 237: 35-40. PMID: 39581517, PMCID: PMC11761372, DOI: 10.1016/j.amjcard.2024.11.028.Peer-Reviewed Original ResearchCleveland Clinic FoundationHypertrophic cardiomyopathyMedian follow-up periodHypertrophic cardiomyopathy therapyMonitoring Treatment ResponseFollow-up periodImpact of therapyAtlantic Health SystemLack of improvementOral alternativePost-SRTMedical therapyTreatment responseMulticenter evaluationInterventricular septumPercutaneous reductionMavacamtenTherapyPatientsClinic FoundationPoint-of-care monitoringECGECG imagesScoresHealth systemAutomated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing
Nargesi A, Adejumo P, Dhingra L, Rosand B, Hengartner A, Coppi A, Benigeri S, Sen S, Ahmad T, Nadkarni G, Lin Z, Ahmad F, Krumholz H, Khera R. Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing. JACC Heart Failure 2024, 13: 75-87. PMID: 39453355, DOI: 10.1016/j.jchf.2024.08.012.Peer-Reviewed Original ResearchReduced ejection fractionEjection fractionHeart failureLeft ventricular ejection fractionVentricular ejection fractionYale-New Haven HospitalIdentification of patientsCommunity hospitalIdentification of heart failureLanguage modelNorthwestern MedicineMeasure care qualityQuality of careNew Haven HospitalDeep learning-based natural language processingHFrEFGuideline-directed careDeep learning language modelsMIMIC-IIIDetect HFrEFNatural language processingReclassification improvementHospital dischargePatientsCare qualityDyspnea in a Patient With Metastatic Breast Cancer
Tarras E, Sen S, Wang H, Singh I. Dyspnea in a Patient With Metastatic Breast Cancer. CHEST Pulmonary 2024, 2: 100074. DOI: 10.1016/j.chpulm.2024.100074.Peer-Reviewed Original ResearchTumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization
Tarras E, Sen S, Wang H, Singh I. Tumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization. 2024, a2208-a2208. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2208.Peer-Reviewed Original ResearchAssociation of cardiovascular diseases with cognitive performance in older adults
Park D, Jamil Y, Babapour G, Kim J, Campbell G, Akman Z, Kochar A, Sen S, Samsky M, Sikand N, Frampton J, Damluji A, Nanna M. Association of cardiovascular diseases with cognitive performance in older adults. American Heart Journal 2024, 273: 10-20. PMID: 38575050, PMCID: PMC11162917, DOI: 10.1016/j.ahj.2024.03.016.Peer-Reviewed Original ResearchAnimal Fluency TestOlder adultsCERAD-DRDSST scoresCardiovascular diseaseNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyCongestive heart failureFree of cardiovascular diseaseFluency testCardiovascular disease subtypesNutrition Examination SurveyAssociation of cardiovascular diseaseAnimal Fluency test scoreCognitive performanceLower cognitive performanceCoronary heart diseaseHeart failureCVD subtypesExamination SurveyAssess cognitive performanceAdultsCognitive functionHeart diseaseScores
Clinical Care
Overview
Sounok Sen, MD, is a cardiologist specializing in advanced heart failure, heart transplantation, and mechanical circulatory support. He cares for adult patients both in the clinic and in the hospital. In addition to caring for patients with new diagnoses of heart failure and those with chronic heart failure, he sees patients who have received or are being considered for heart transplantation and left ventricular assist devices (LVADs).
Dr. Sen was inspired to care for patients with heart failure by mentors he worked with during his cardiology fellowship at Duke University School of Medicine. “Before then, I didn’t truly appreciate the full potential of these advanced therapies. But being part of that multidisciplinary care team and experiencing firsthand how these therapies change people’s lives, I was inspired, ” he says.
Each heart patient is unique, Dr. Sen says, and that’s something he takes very seriously. “In cardiology, we have the benefit of looking at large clinical trials to help guide patient care, but we also know that everyone is different. I believe in taking an individualized approach to each patient and their journey.” That requires understanding each patient’s expectations and educating and counseling them as they prepare to undergo treatments that could help them reach their goals.
While he considers himself a clinician first, Dr. Sen is motivated to investigate approaches that better enable patients to access lifesaving therapies such as LVADs and heart transplants, including strategies that would make more donor hearts available to those who are waiting for them.
Clinical Specialties
Fact Sheets
Heart Transplant
Learn More on Yale MedicineVentricular Assist Device (VAD)
Learn More on Yale MedicineHypertrophic Cardiomyopathy
Learn More on Yale MedicineHeart Failure Surgery
Learn More on Yale Medicine
Yale Medicine News
News
News
- June 26, 2025
For Heart Transplant Patients, Blood Test May Detect Rejection Earlier and More Easily
- May 01, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (May 2024)
- May 11, 2023
Discoveries & Impact (May 2023)
- February 01, 2023
2023 American College of Cardiology late-breaking clinical trials and abstracts from Yale