Katherine Clark, MD, MBA, FACC
Assistant Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2026
No Heart Failure Patient Left Behind: Making GDMT a Reality for All
Young G, Batlle J, Clark K. No Heart Failure Patient Left Behind: Making GDMT a Reality for All. Journal Of Cardiac Failure 2026 PMID: 41850616, DOI: 10.1016/j.cardfail.2026.03.004.Commentaries, Editorials and Letters
2025
Unequal Hearts: Racial Disparities Persist in Heart Transplant Outcomes
Batlle J, Clark K. Unequal Hearts: Racial Disparities Persist in Heart Transplant Outcomes. Journal Of The American Heart Association 2025, 14: e045280. PMID: 40996047, PMCID: PMC12684488, DOI: 10.1161/jaha.125.045280.Commentaries, Editorials and LettersElectronic health record nudges to optimize guideline-directed medical therapy for heart failure
Fuery M, Clark K, Sikand N, Tabtabai S, Sen S, Wilson F, Desai N, Ahmad T, Samsky M. Electronic health record nudges to optimize guideline-directed medical therapy for heart failure. Heart Failure Reviews 2025, 30: 771-776. PMID: 40106122, DOI: 10.1007/s10741-025-10503-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsElectronic health recordsClinical decision supportGuideline-directed medical therapyPotential of electronic health recordsElectronic health record systemsDiverse healthcare settingsGDMT adherenceCare qualityClinician workflowHealth recordsAlert contentHF careHealthcare settingsPatient careInformed treatment decisionsTargeted alertingQuality gapEnhanced usabilityImprove heart failureHeart failureDecision supportReal-timeCareTreatment decisionsAlerting strategyCollaborative Management of Hyperkalemia in Patients with Complex Heart Failure
Kelepouris E, Desai N, Clark K, Kosiborod M, Budden J, Waechter S, Böhm M. Collaborative Management of Hyperkalemia in Patients with Complex Heart Failure. Case Reports In Nephrology And Dialysis 2025, 15: 47-52. PMID: 40237021, PMCID: PMC11999659, DOI: 10.1159/000543931.Peer-Reviewed Original ResearchRenin-angiotensin-aldosterone system inhibitorsManagement of hyperkalemiaHeart failureDown-titrationSerum K+ levelsAcute HF decompensationOptimal medical therapyUp-titrationReoccurrence of symptomsRAASi therapySerum potassiumMedical therapyClinical outcomesPotassium dietSystem inhibitorsHF patientsHyperkalemiaHF decompensationKidney diseasePatientsTreatment managementLocal guidelinesTherapyInterdisciplinary team discussionsSerumFrom Inflammation to Inspiration and Innovation: A New Perspective on the Utility of Anti-inflammatory Therapies for Acute Heart Failure
Sobieraj M, Bansal K, Clark K. From Inflammation to Inspiration and Innovation: A New Perspective on the Utility of Anti-inflammatory Therapies for Acute Heart Failure. Journal Of Cardiac Failure 2025, 31: 367-368. PMID: 39824279, DOI: 10.1016/j.cardfail.2025.01.002.Commentaries, Editorials and Letters
2024
We Have More Steps Along the Path to Routine Cardiorespiratory Fitness Evaluation
Colna M, Alaiwi S, Clark K. We Have More Steps Along the Path to Routine Cardiorespiratory Fitness Evaluation. JACC Advances 2024, 3: 101080. PMID: 39184126, PMCID: PMC11341924, DOI: 10.1016/j.jacadv.2024.101080.Commentaries, Editorials and LettersMedicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications
Young G, Bansal K, Riello R, Clark K, Dhruva S, Faridi K, Desai N. Medicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications. JAMA Network Open 2024, 7: e2412437. PMID: 38771578, PMCID: PMC11109768, DOI: 10.1001/jamanetworkopen.2024.12437.Peer-Reviewed Original ResearchAre High-Volume Cardiologists Ready for EHR Best Practice Alerts? ∗
Alaiwi S, Colna M, Clark K. Are High-Volume Cardiologists Ready for EHR Best Practice Alerts? ∗. JACC Heart Failure 2024, 12: 675-677. PMID: 38206232, DOI: 10.1016/j.jchf.2023.12.003.Commentaries, Editorials and Letters
2023
Rationale, Design, and Patient Characteristics of a Cluster-Randomized Pragmatic Trial to Improve Mineralocorticoid Antagonist Use
Clark K, Victoria-Castro A, Ghazi L, Yamamoto Y, Coronel-Moreno C, Kadhim B, Riello R, O'Connor K, Ahmad T, Wilson F, Desai N. Rationale, Design, and Patient Characteristics of a Cluster-Randomized Pragmatic Trial to Improve Mineralocorticoid Antagonist Use. JACC Heart Failure 2023, 12: 322-332. PMID: 37943221, DOI: 10.1016/j.jchf.2023.08.025.Peer-Reviewed Original ResearchBest practice alertMineralocorticoid receptor antagonistsNovel potassium bindersPotassium bindersEligible patientsUsual careEjection fractionSerum potassiumHistory of hyperkalemiaIncidence of hyperkalemiaStrong guideline recommendationsHeart failure hospitalizationReduced ejection fractionLaboratory test valuesPopulation health outcomesHyperkalemia treatmentMRA prescriptionAntagonist useFailure hospitalizationPatient characteristicsSecondary outcomesHeart failurePrimary outcomeGuideline recommendationsOutpatient visitsDefining a path toward improved heart failure care.
Desai N, Clark K. Defining a path toward improved heart failure care. The American Journal Of Managed Care 2023, 29: s195-s200. PMID: 37677744, DOI: 10.37765/ajmc.2023.89418.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsValue-based paymentQuality of lifeSocial determinantsSocial determinants of healthHigh-quality patient careValue-based payment modelsHospital-at-homeCare delivery approachesDeterminants of healthHF clinical careLow-quality careExcess health care costsHealth care costsHeart failure carePatient-reported outcomesLower-cost careAssociated with higher hospital costsWellness initiativesFFS modelPayment reformOptimal healthPatient careCare costsHigher hospital costsClinical care
Clinical Care
Overview
Katherine Clark, MD, MBA, is a cardiologist who specializes in advanced heart failure and transplant. She takes care of patients with heart failure as well as those who have received or are being considered for heart transplantation and left ventricular assist devices (LVADs).
Dr. Clark says she was drawn to her field from the time she was a child. When her grandmother was diagnosed with heart failure in the 1990s, she was initially told she was a ticking time bomb and there was little to do; but once she found a heart failure specialist, she was treated with multiple new medications for that time, which ultimately gave her another 20 years.
“I would help her manage her medicines and go on frequent walks between her cardiac rehab sessions,” Dr. Clark says. “I was fortunate to grow up with her, and I’d often attend her heart failure appointments. She, as well as my entire family, greatly valued our relationship with her heart failure physician, and that made a strong impression on me.”
As a result of growing up being exposed to life with heart failure, Dr. Clark says the best part of my job is the ability to make a difference by improving a patient’s quality of life, while developing relationships with patients and their families.
“I explain to patients that with heart failure, the pump function of their heart has weakened, and by working together as a team, we have a great toolbox of medicines and devices to make the heart function stronger. And in looking forward, many exciting new developments are in the pipeline,” she says.
She also strongly values the team-oriented nature of caring for patients with heart failure, working together with nurses, pharmacists, transplant and LVAD coordinators, cardiac surgeons, and social workers to deliver comprehensive care.
Dr. Clark’s research interests include leveraging innovation through new therapies, technology such as advanced imaging modalities, and payment and care delivery models to improve treatment with heart failure. “We are at an exciting time in the field, as numerous innovations are happening along many avenues,” she says.
At Yale School of Medicine, Dr. Clark is an assistant professor of cardiology.
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