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Silvia Vilarinho, MD, PhD

Assistant Professor of Medicine (Digestive Diseases) and of Pathology

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Silvia Vilarinho, MD, PhD

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Office Location



Silvia Vilarinho is a physician-scientist who uses genetics, genomics and human samples to investigate the molecular basis of various liver diseases of unknown etiology. Using these approaches, we have identified a new mendelian form of non-cirrhotic portal hypertension, a novel bile acid disorder due to ACOX2 deficiency and a new cholestatic disorder due to mutations in KIF12. Our research goal is to discover new genes important in liver function both in health and disease and to use cell biology and animal models to determine the specific mechanism(s) linking mutant gene to disease, with potential diagnostic, therapeutic and prognostic applications.

Education & Training

  • PhD
    University of Porto, Portugal (2008)
  • MD
    University of Porto, Portugal (2004)
  • Fellowship
    Yale University
  • Residency
    Yale University
  • Internship
    University of Minnesota
  • Board Certification
    AB of Internal Medicine, Internal Medicine (2012)

Honors & Recognition

Junior Faculty Samuel Kushlan Award2017
AASLD Sheila Sherlock Clinical and Translational Research Award2015
Samuel Kushlan Award for Excellence in Research during Digestive Diseases Fellowship2015

Departments & Organizations