Shreyak Sharma, MD
Assistant ProfessorAbout
Research
Publications
2023
Early Flexible Sigmoidoscopy Improves Clinical Outcomes in Acute Severe Ulcerative Colitis
Sharma S, Li D, Levine L, Chaar A, McMillan C, Gaidos J, Proctor D, Al-Bawardy B. Early Flexible Sigmoidoscopy Improves Clinical Outcomes in Acute Severe Ulcerative Colitis. Crohn's & Colitis 360 2023, 5: otad032. PMID: 37323477, PMCID: PMC10263117, DOI: 10.1093/crocol/otad032.Peer-Reviewed Original ResearchAcute severe ulcerative colitisSevere ulcerative colitisClinical outcomesSigmoidoscopy groupHospital stayFlexible sigmoidoscopyUlcerative colitisIntravenous corticosteroid useRate of colectomyRisk of colectomyHours of admissionOpioid medication useShorter hospital stayCohort of patientsFavorable clinical outcomeLarge prospective studiesRelevant clinical outcomesColectomy rateCorticosteroid useSecondary outcomesMedication usePrimary outcomeProspective studyRetrospective studySigmoidoscopy
2022
Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding
Li D, Ong S, Hughes M, Hung K, Agarwal R, Alexis J, Damianos J, Sharma S, Pires J, Nanna M, Laine L. Deprescription of aspirin for primary prevention is uncommon at discharge in hospitalised patients with gastrointestinal bleeding. Alimentary Pharmacology & Therapeutics 2022, 57: 94-102. PMID: 36394111, DOI: 10.1111/apt.17278.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsGastrointestinal bleedingPrimary preventionCardiovascular eventsRisk of MACEYale-New Haven HospitalPrimary cardiovascular preventionAdverse cardiovascular eventsKaplan-Meier curvesLong-term outcomesRisk-benefit ratioLog-rank testAspirin 81Hospitalised patientsPrimary endpointSecondary endpointsCardiovascular preventionSubsequent hospitalisationMedian ageDeprescriptionHigh riskAspirinHospitalisationPatientsPreventionDiagnostic Momentum in Acute Liver Injury: an Exercise in Clinical Reasoning
Thomas I, Roberts A, Sharma S, Penner J, Taddei T. Diagnostic Momentum in Acute Liver Injury: an Exercise in Clinical Reasoning. Journal Of General Internal Medicine 2022, 37: 2861-2865. PMID: 35676586, PMCID: PMC9411385, DOI: 10.1007/s11606-022-07673-4.Peer-Reviewed Original Research
2020
Acute kidney injury in renal transplant recipients undergoing cardiac surgery
Hundemer G, Srivastava A, Jacob K, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel K, Hirji S, Pelletier M, Safa K, Kulvichit W, Kellum J, Riella L, Leaf D. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrology Dialysis Transplantation 2020, 36: 185-196. PMID: 32892219, PMCID: PMC7771983, DOI: 10.1093/ndt/gfaa063.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsAcute kidney injuryNon-RTRsCardiac surgeryCalcineurin inhibitorsRisk factorsTransplant recipientsKidney injuryType of cardiac surgeryKidney diseaseRates of acute kidney injuryRisk of acute kidney injuryDeceased donorsGlobal Outcomes criteriaLiving donorsRetrospective cohort studyAssociated with higher ratesChronic kidney diseaseTrough levelsClinical characteristicsAcademic medical centerCohort studySurgeryHigh riskMedical CenterAcute Kidney Injury Following Paracentesis Among Inpatients With Cirrhosis
Seethapathy H, Sharma S, Zhao S, Chung R, Connor M, Leaf D, Allegretti A. Acute Kidney Injury Following Paracentesis Among Inpatients With Cirrhosis. Kidney International Reports 2020, 5: 1305-1308. PMID: 32775831, PMCID: PMC7403547, DOI: 10.1016/j.ekir.2020.05.014.Peer-Reviewed Original ResearchSoluble Urokinase Receptor and Acute Kidney Injury
Samman Tahhan A, Sharma S, Pan J, Hayek S, Leaf D, Raad M, Waikar S, Sever S, Camacho A, Dande R, Ibrahim N, Baron R, Altintas M, Wei C, Sheikh-Hamad D, Holliday M, Januzzi J, Weisbord S, Quyyumi A, Reiser J, Wang X. Soluble Urokinase Receptor and Acute Kidney Injury. The New England Journal Of Medicine 2020, 382: 416-426. PMID: 31995687, PMCID: PMC7065830, DOI: 10.1056/nejmoa1911481.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAnimalsAntibodies, MonoclonalBiomarkersCardiac Surgical ProceduresCoronary AngiographyCritical IllnessDisease Models, AnimalFemaleHumansIntensive Care UnitsKidney TubulesMaleMiceMice, TransgenicMiddle AgedOdds RatioPodocytesPostoperative ComplicationsReceptors, Urokinase Plasminogen ActivatorRisk AssessmentUrokinase-Type Plasminogen ActivatorConceptsSoluble urokinase plasminogen activator receptorUrokinase plasminogen activator receptorAcute kidney injurySoluble urokinase plasminogen activator receptor levelsLevels of soluble urokinase plasminogen activator receptorKidney injuryPlasminogen activator receptorCoronary angiographyHK-2 cellsCardiac surgeryPlasma level of soluble urokinase plasminogen activator receptorPlasma levelsSoluble urokinase plasminogen activator receptor quartilePatients to acute kidney injuryContrast materialHistological evidenceAssociated with acute kidney injuryRisk of acute kidney injuryActivator receptorEvidence of acute kidney injuryAntibody to urokinase plasminogen activator receptorHK-2Wild-type miceCritically ill patientsCritically ill cohort
2019
Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention
Sharma S, Leaf D. Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention. Journal Of The American Society Of Nephrology 2019, 30: 2060-2071. PMID: 31554656, PMCID: PMC6830795, DOI: 10.1681/asn.2019060595.Peer-Reviewed Original ResearchConceptsAKI preventionClinical trialsTherapeutic strategiesIron chelatorsPathophysiology of AKIPrevention of AKIAcute organ injuryRoute of administrationMultiple other organsSpectrum of insultsPotential therapeutic strategyDosing regimenOrgan injuryPatient populationIron chelating agentsAnimal modelsPublic health concernAKIHuman studiesSmall studyClinical settingTherapeutic targetOther organsAdverse effectsPrevention
News
News
- September 19, 2023
Welcome New Postdocs, Postgrads, and Clinical Fellows in the Section of Digestive Diseases (September 2023)
- August 16, 2023
Welcome New Postdocs, Postgrads, Fellows, Faculty & Staff! (August 2023)
- August 10, 2023
Ulcerative Colitis: Early Sigmoidoscopy & Clinical Outcomes (Discoveries & Impact August 2023)