Serena Susan Spudich, MD, MA

2025

• Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy

  Chan P, Sacdalan C, Pinyakorn S, Kroon E, Colby D, Promsena P, Sriplienchan S, Phanuphak N, Vasan S, Valcour V, Paul R, Gisslén M, Zetterberg H, Trautmann L, Spudich S. Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy. Journal Of Infectious Diseases 2025, jiaf583. PMID: 41254882, DOI: 10.1093/infdis/jiaf583.

  Peer-Reviewed Original Research

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• Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV

  Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolzenius J. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 105: e214445. PMID: 41172230, DOI: 10.1212/wnl.0000000000214445.

  Peer-Reviewed Original Research

• Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2--LTR Circles Over 12 Weeks.

  Reed JC, Hall L, McKhann A, Kwak G, Goecker EA, Coombs RW, Chen H, Roa J, Vecchio A, Daar ES, Hunt PW, Marra CM, Campbell TB, Ma Q, Swaminathan S, Macatangay BJC, Morse GD, Miller T, Rusin D, Ha B, Alston-Smith B, Paul R, Letendre SL, Spudich SS, Greninger AL. Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2--LTR Circles Over 12 Weeks. Open Forum Infect Dis 2025, 12: ofaf594. PMID: 41141451, DOI: 10.1093/ofid/ofaf594.

  Peer-Reviewed Original Research

• CSF immune cell alterations in women with neuropsychiatric Long COVID

  Orlinick B, Mehta S, McAlpine L, Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J, Das B, Patel V, Filippidis P, Corley M, Spudich S, Farhadian S. CSF immune cell alterations in women with neuropsychiatric Long COVID. The Journal Of Infectious Diseases 2025, jiaf468. PMID: 40920586, DOI: 10.1093/infdis/jiaf468.

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• Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort.

  Horwitz LI, Becker JH, Huang W, Akintonwa T, Hornig-Rohan MM, Maranga G, Adams DR, Albers MW, Ayache M, Berry J, Brim H, Bryan TW, Charney AW, Clark RA, Cortez MM, D'Anza B, Davis H, Donohue SE, Erdmann N, Flaherman V, Fong TG, Frontera JA, Goldberg MP, Goldman JD, Harkins MS, Hodder SL, Jacoby VL, Jagannathan P, Jia X, Kelly JD, Krishnan JA, Kumar A, Laiyemo AO, Levitan EB, Martin JN, McCaffrey KM, McComsey GA, Metz TD, Murthy G, Nguyen H, Okumura M, Parry S, Parthasarathy S, Patterson TF, Peluso MJ, Sorochinsky C, Walker T, Wiegand SL, Wiley Z, Wisnivesky J, Ashktorab H, Foulkes A, Lee-Iannotti JK, Researching COVID to Enhance Recovery Consortium. Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort. JAMA Netw Open 2025, 8: e2533815. PMID: 40996759, DOI: 10.1001/jamanetworkopen.2025.33815.

  Peer-Reviewed Original Research

• Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection

  Chan P, Moreland S, Sacdalan C, Colby D, Ocampo F, Promsena P, Sriplienchan S, Wattana J, Intasan J, Phanuphak N, Vasan S, Paul R, Trautmann L, Spudich S, Kroon E, Team T. Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection. HIV Medicine 2025, 26: 1619-1625. PMID: 41047593, DOI: 10.1111/hiv.70085.

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• Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy

  Chavez J, Bolzenius J, Chan P, Cho K, Mannarino J, Sacdalan C, Farhadian S, Trautmann L, Ndhlovu L, Tipsuk S, Crowell T, Krebs S, Slike B, Suttichom D, Colby D, Phanuphak N, Kroon E, Vasan S, Sriplienchan S, Spudich S, Paul R, Carrico A. Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy. Brain Behavior & Immunity - Health 2025, 48: 101079. PMID: 40808976, PMCID: PMC12345309, DOI: 10.1016/j.bbih.2025.101079.

  Peer-Reviewed Original Research

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• Characterizing Long COVID Symptoms During Early Childhood

  Gross R, Thaweethai T, Salisbury A, Kleinman L, Mohandas S, Rhee K, Snowden J, Tantisira K, Warburton D, Wood J, Kinser P, Milner J, Rosenzweig E, Irby K, Flaherman V, Karlson E, Chibnik L, Pant D, Krishnamoorthy A, Gallagher R, Lamendola-Essel M, Hasson D, Katz S, Yin S, Dreyer B, Blancero F, Carmilani M, Coombs K, Fitzgerald M, Letts R, Peddie A, Foulkes A, Stockwell M, Darden P, Dixon L, Evans D, Garbe C, Hobart-Porter L, Howard L, Hummel K, Krehbiel H, Spradlin H, Yount P, Adam G, Angal J, Barber M, Clark K, Dos Reis C, Freesemann M, Friedrich C, Hockett C, Johannsen R, Johnson-Vonk E, Kaiser C, Kruse A, Lang J, Lim P, McCoy M, Miller L, Petereit (Cerkovnik) S, RiChard (Werpy) J, Seiler J, Sundleaf B, Svendsen J, Trosper B, Vermeulen O, Young S, Dabney S, Fahrner M, Gallagher T, Martini K, McNally M, Vivensi Stiverson S, Balaraman V, Cheung J, Hong T, Kalua S, Minami E, Siu A, Tong M, Dantas M, Kasmarcak T, Milks K, Ikomi C, Meyer M, Nguyen C, Pellicciotti G, Phan T, Ravin K, Reynolds V, Strang A, Thacker D, Eckrich D, Goetter A, Katz C, Kowal K, McDevitt C, Agosto Roman G, Alshawabkeh A, Ayala Ortiz I, Casey V, Cordero J, De Jesus J, Galan Rivera C, Huerta-Montanez G, Otero N, Rivera Robles M, Roman P, Roman G, Rosario-Pabon Z, Santiago X, Velez-Vega C, Vergara C, Albarado B, Allen T, Attuso A, Ayers T, Bebler E, Bella G, Bennett A, Brown J, Carville A, Darby S, Devall K, Dragg A, Elderedge A, Fontenot E, Fry G, Gildersleeve B, Goff S, Harrington L, Jones L, Kaiser V, Lee Y, Lee S, LeJeune E, Leonhard R, Levatino J, Lewis D, Lloyd A, Monce R, Munro S, Phillips M, Pucheu B, Rachal E, Rood J, Roussel S, Rumsey R, Sanford C, Santos M, Stafford A, Thomassie A, Waguespack C, Walgamotte K, Welch M, Windham A, Bell T, Boyd J, Dasgupta S, Deans S, Harris K, Hemmerle M, King S, McGuire C, Merten B, Morris S, Ray M, Reinhardt B, Shemwell S, Simeon T, Walker K, Watson S, Weakley K, Figliomeni J, Fischer L, Hoover D, Morse M, Nabower A, Roberts E, Sato A, Von Bon J, Archuleta D, Brito R, Campbell R, Chavez J, Dehority W, Garcia-Soberanez N, Gronert E, Kadish M, Larrabee J, Lovato D, Luo K, Martinez N, Merlino A, Reese E, Ward S, Wilson K, Brown R, Butchee R, Fergeson G, McKee R, Mohler B, Moore T, Owens V, Stubbs S, VanWagoner T, Bethel M, Chassereau L, Lahiri T, Lake L, Moffett K, Polak E, Stutler S, Workman C, Carpenter E, Dhindsa I, Mejia S, Moghadam N, Mulder C, O'Neil S, Osornio A, Rios A, Rosen S, Smith A, Tabibi D, Tang S, Teame A, Stockwell M, Anderson B, Aquino T, Berg E, Caddle S, Catallozzi M, Chung W, Connors T, De A, Diaz Perez A, DiLorenzo M, Dumitriu D, Farooqi K, Fremed M, Goldman S, Kaplan K, Krishnan U, Layton A, Lignelli-Dipple A, McClaren S, Overdevest J, Rodriguez M, Selman J, Silver W, Silverio R, Valdez de Romero A, Vargas C, Caputo D, Leggieri C, Pretsch P, Davis K, Griffith M, Harris D, Macario E, Steffes J, Torres A, Day C, Howell K, Mains M, Bean E, DeFelice C, El Chebib H, Herbst K, Lesmes S, Santos M, Schulman N, Brooks-Greien A, Colin K, Juarez-Colunga A, Manning B, Shields J, York D, Griswold J, Lee D, Nowakowski A, Riordan M, Aamir R, Abuzahrieh M, Bangalore N, Brown A, Dalton W, Fortuna S, Minium J, Rosolowski B, Ahmed A, Braniecki S, Contreras M, Jain S, Kaseta S, Messer Z, Ramirez A, Singh A, WIlliams R, Akerlundh A, Akshoomoff N, Arroyo M, Barrientos W, Bhattacharjee R, Chao B, Diaz M, Garcia S, Garcia S, Gomez G, Herrera T, Holguin M, Khare M, Kiernan E, Landeo Gutierrez J, Matta I, Reyes S, Ryu J, Sanchez C, Schreck A, Warner M, Cerracchio L, Folnagy A, Gzemski S, Hao Y, Li S, Moroso S, Ness-Cochinwala M, Patel A, Richlin B, Sharma H, Soto D, Suarez C, Vargas Forero B, Ricciardi E, Trespalacios V, Kluko M, Rhee K, Tantisira K, Acosta Valle D, Chao B, Choudhary A, Glenn-Arroyo M, Kiernan E, Landeo-Gutierrez J, Madan A, McConnaughey K, Ramos Vallejo L, Sanchez C, Suarez M, Caldas S, Castro Ovalle T, Chung A, Farkas J, Isidoro-Chino M, Kesebir D, Kim E, Quarless A, Schlechter A, Srinivasan R, Barry F, Burton P, Cano Lorente R, Cummins C, Wehbe S, Espinoza J, Moyer S, Rider A, Russell S, Schecter M, Stevenson L, Burns J, Spudich S, Bailey C, Cicek M, Cortez M, Davis Blakley F, Goff D, Lasky-Su J, Newman L, Ofotokun I, Seshadri S, Stone J, Taylor B, Utz P, Williams N, Abella J, Barnette Q, Bevc C, Beverly J, Ceger P, Croxford J, Cunningham E, Enger M, Fain K, Farris T, Hanlon S, Hines D, Johnson-Lawrence V, Jordan K, Lefebvre C, Linas B, Luukinen B, Mandal M, McKoy N, Nance S, Oakland A, Pasquarelli D, Quiner C, Sembajwe R, Shaw G, Thornburg V, Tosco K, Wright H, Hochman J, Horwitz L, Katz S, Troxel A, Adler L, Akinbo P, Almenana R, Bello O, Bhuiyan S, Blachman N, Branski R, Briscoe J, Brosnahan S, Bueler E, Burgos Y, Caplin N, Chaplin D, Chen Y, Cheng S, Choe P, Choi J, Chung A, Church R, Cobos S, Croft N, Cruz Irving A, Del Boccio P, Díaz I, Doshi V, Ebel S, Faustin A, Febres E, Fine J, Fink S, Frontera J, Gonzalez-Duarte A, Hill S, Islam S, Johnson S, Kansal N, Kenney R, Kewlani D, Laynor G, Leon T, Lewczak Z, Linton J, Logan M, Malik N, Mamistvalova L, Mandel H, Maranga G, Mathews P, Mattoo A, Mei T, Mendelsohn A, Mercier E, Millar Vernetti P, Miller M, Mitchell M, Moreira A, Mudumbi P, Nahin E, Nair N, Nekulak J, Owens K, Parent B, Patibandla N, Petrov P, Postelnicu R, Randall I, Rao P, Rapkiewicz A, Rizzo J, Rosas J, Rose C, Saint-Jean C, Santacatterina M, Shah B, Shaukat A, Simon N, Simsir A, Stinson M, Tang W, Tatapudi V, Thawani S, Thomas M, Thorpe L, Tom M, Treiha E, Truong J, Udosen M, Velazquez-Perez J, Vernetti P, Vidal C, Viswanathan A, Wong C, Wood M, Wuller S, Young C, Zaretsky J, Zavlunova S, Foulkes A, Murphy S, Ahirwar S, Ainsworth L, Ajani S, Alsheikh A, Atchley-Challenner R, Avilach P, Balan T, Benik N, Benoit B, Bonaventura W, Boutin N, Brion B, Cagan A, Cai T, Cao T, Castro V, Cerretani X, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fang M, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Nazaire M, Neils G, Norman J, Paik H, Park H, Qian Z, Rossi-Roh K, Santacroce L, Selvaggi C, Simons W, Simpson L, Strasser Z, Tariq A, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang H, Wang T, Wattanasin N, Weber G, Williams M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Brown H, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Blomkalns A, Bassett I, Clifton R, Davis H, Erdmann N, Gage Witvliet M, Goldberg M, Guan Z, Jain M, Klein J, Martinez T, McGrath R, Parthasarathy S, Pemu P, Rutter J, Aschner J, Atz A, Banerjee D, Bogie A, Bukulmez H, Clouser K, Cottrell L, Cowan K, D’Sa V, Dozor A, Elliott A, Faustino E, Fiks A, Gaur S, Gennaro M, Gordon S, Hasan U, Hester C, Hogan A, Hsia D, Kaelber D, Kosut J, Krishnan S, McCulloh R, Michelow I, Nolan S, Oliveira C, Olson L, Pace W, Palumbo P, Raissy H, Reyes A, Ross J, Salazar J, Selvarangan R, Stein C, Stevenson M, Teufel R, Werzberger A, Westfall J, Zani K, Zempsky W, Zimmerman E, Bind M, Chan J, Guan Z, Morse R, Reeder H, Metz T, Newburger J, Truong D. Characterizing Long COVID Symptoms During Early Childhood. JAMA Pediatrics 2025, 179: 781-792. PMID: 40554463, PMCID: PMC12117493, DOI: 10.1001/jamapediatrics.2025.1066.

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• Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV

  Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolenzius J, Team A. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 104: e213591. PMID: 40327828, PMCID: PMC12060792, DOI: 10.1212/wnl.0000000000213591.

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  MeSH Keywords and Concepts

• Pharmacokinetic approaches to standardize antiviral exposure in cerebrospinal fluid.

  Avedissian SN, Mu Y, McCarthy C, Bosch RJ, Spudich S, Gandhi RT, McMahon DK, Eron JJ, Mellors JW, Liu J, Podany AT, Fletcher CV. Pharmacokinetic approaches to standardize antiviral exposure in cerebrospinal fluid. Pharmacotherapy 2025, 45: 251-263. PMID: 40152440, DOI: 10.1002/phar.70013.

  Peer-Reviewed Original Research