Sean Bickerton, MD, PhD
Assistant Professor of Pediatrics (Hospital Medicine)About
Research
Publications
2025
CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cells that stabilize Tregs for long-term therapeutic efficacy in immune-mediated disorders
Horwitz D, Kim D, Kang C, Brion K, Bickerton S, La Cava A. CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cells that stabilize Tregs for long-term therapeutic efficacy in immune-mediated disorders. Frontiers In Immunology 2025, 16: 1587237. PMID: 40799646, PMCID: PMC12339487, DOI: 10.3389/fimmu.2025.1587237.Peer-Reviewed Original ResearchConceptsNK cellsIL-2TGF-bFatal graft-versus-host diseasePoly(lactic-co-glycolic) acidGraft-versus-host diseaseLong-term immune toleranceLong-term therapeutic efficacyNK cell depletionInduction of TregsT regulatory cellsImmune-mediated disordersTreatment of miceAnti-CD2 antibodiesImmune-mediated diseasesTGF-b signalingCell-targeted approachesTolerogenic cellsCD4+Immune toleranceTolerogenic responsesTregsTherapeutic efficacyCell depletionImmunogenic response
2024
Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen
Horwitz D, Wang J, Kim D, Kang C, Brion K, Bickerton S, La Cava A. Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen. Frontiers In Immunology 2024, 15: 1429335. PMID: 39131162, PMCID: PMC11310063, DOI: 10.3389/fimmu.2024.1429335.Peer-Reviewed Original ResearchNP-treated miceT regulatory cellsMixed lymphocyte reactionDendritic cellsTolerogenic nanoparticlesAllogeneic cellsIL-2CD8+ T regulatory cellsGraft-versus-host diseaseAlloantigen-specific TregInhibition of mixed lymphocyte reactionTGF-bRecipient dendritic cellsGraft-versus-hostTolerogenic dendritic cellsResponse to alloantigensTolerance to alloantigensStrains of miceAlloantigen immunizationDecreased alloreactivityTolerogenic phenotypeCD4+Allogeneic splenocytesAllograft rejectionImmune suppression
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Pediatrics; Pediatric Critical Care Medicine
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