Sean Bickerton
Hospital ResidentAbout
Research
Publications
2024
Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen
Horwitz D, Wang J, Kim D, Kang C, Brion K, Bickerton S, La Cava A. Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen. Frontiers In Immunology 2024, 15: 1429335. DOI: 10.3389/fimmu.2024.1429335.Peer-Reviewed Original ResearchNP-treated miceT regulatory cellsMixed lymphocyte reactionDendritic cellsTolerogenic nanoparticlesAllogeneic cellsIL-2CD8+ T regulatory cellsGraft-versus-host diseaseAlloantigen-specific TregInhibition of mixed lymphocyte reactionTGF-bRecipient dendritic cellsGraft-versus-hostTolerogenic dendritic cellsResponse to alloantigensTolerance to alloantigensStrains of miceAlloantigen immunizationDecreased alloreactivityTolerogenic phenotypeCD4+Allogeneic splenocytesAllograft rejectionImmune suppression