Santiago Clocchiatti-Tuozzo, MD, MHS
he/him/his
Postdoc FellowDownloadHi-Res Photo
About
Titles
Postdoc Fellow
Biography
Santiago Clocchiatti-Tuozzo MD, MHS, is a T32 Postdoctoral Fellow in Geriatric Clinical Epidemiology and Aging-Related Research at the Aging Department and Falcone Lab in the Department of Neurology, Yale University. He completed his MD Summa Cum Laude at the University of Buenos Aires, Argentina before emigrating to his new home in the United States to pursue advanced research training in the intersection of neurology and aging, population genetics, genomic medicine, and data sciences. Dr. Clocchiatti-Tuozzo’s work focuses on understanding how genetic variations and their phenotypes, such as cardiovascular and neurological risk factors, can strongly influence brain health and aging-related traits and outcomes: dementia, cognitive decline, frailty, disability, and more. Key areas of emphasis within his research framework are the utilization of multiple different data sources including neuroimaging, eHR, statistical analyses with big data, social determinants of health, and other -omics technologies.
Departments & Organizations
Education & Training
- MHS
- Yale School of Public Health, Bioinformatics (2024)
- MD
- University of Buenos Aires (2021)
Research
Overview
Medical Research Interests
Cerebrovascular Disorders; Dementia; Intracranial Hemorrhages; Stroke
Public Health Interests
Genetics, Genomics, Epigenetics
ORCID
0000-0001-5377-434X- View Lab Website
Falcone Labs
Research at a Glance
Yale Co-Authors
Frequent collaborators of Santiago Clocchiatti-Tuozzo's published research.
Publications Timeline
A big-picture view of Santiago Clocchiatti-Tuozzo's research output by year.
Research Interests
Research topics Santiago Clocchiatti-Tuozzo is interested in exploring.
Cyprien Rivier, MD, MSc
Guido J. Falcone, MD, ScD, MPH
Kevin Sheth, MD
Daniela Brenda Renedo, MD
Adam de Havenon, MD, MSCI
Thomas M. Gill, MD
26Publications
33Citations
Publications
Featured Publications
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionBrain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, PMCID: PMC11760050, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessmentAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024, 72: 2989-2999. PMID: 38946154, PMCID: PMC11461103, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseAPOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation
Renedo D, Rivier C, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Wu K, Torres-Lopez V, Huo S, Gunel M, de Havenon A, Sheth K, Matouk C, Falcone G. APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation. JAMA Network Open 2024, 7: e2355368. PMID: 38363572, PMCID: PMC10873768, DOI: 10.1001/jamanetworkopen.2023.55368.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsApolipoprotein E e4Participants of European ancestryRisk of intracerebral hemorrhageHigh risk of intracerebral hemorrhageCross-sectional studyUK BiobankEuropean ancestryHigh riskUs Research ProgramUK Biobank participantsInternational Classification of DiseasesAssociated with higher risk of ICHCross-sectional study of patientsAPOE e4 statusClassification of DiseasesApolipoprotein ENinth Revision and Tenth RevisionAssociated with higher riskIndividual-level dataMultivariate logistic regressionIntracerebral hemorrhage riskBrain arteriovenous malformationsIntracerebral hemorrhageBiobank participantsTenth RevisionThe predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1373797. PMID: 39109366, PMCID: PMC11301016, DOI: 10.3389/fpsyt.2024.1373797.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIncident late-life depressionLate-life depressionBrain health outcomesCare scoresHealth outcomesHealthy lifestyle choicesOutcome of dementiaUK Biobank cohortRisk factorsComposite outcomeCox proportional hazards modelsCare providersBiobank cohortProportional hazards modelIncident casesMultivariate Cox proportional hazards modelRisk of strokeLifestyle changesClinical careLifestyle choicesDementiaBrain healthFuture depressionBaseline evaluationComplete data
2025
Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
D'Aoust T, Clocchiatti‐Tuozzo S, Rivier C, Mishra A, Hachiya T, Grenier‐Boley B, Soumaré A, Duperron M, Le Grand Q, Bouteloup V, Proust‐Lima C, Samieri C, Neuffer J, Sargurupremraj M, Chêne G, Helmer C, Thibault M, Amouyel P, Lambert J, Kamatani Y, Jacqmin‐Gadda H, Tregouët D, Inouye M, Dufouil C, Falcone G, Debette S. Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification. Alzheimer's & Dementia 2025, 21: e70014. PMID: 40042447, PMCID: PMC11881617, DOI: 10.1002/alz.70014.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsOlder community-dwelling peopleCommunity-dwelling peopleDementia risk stratificationVascular contribution to dementiaAssociated with dementia riskGenetic riskDementia clinical trialsApo E4Polygenic risk scoresGenetic risk groupsHigh-risk individualsDementia riskImprove risk predictionEast Asian ancestryAD-PRSPopulation-basedPolygenic scoresRisk stratificationMemory-clinic patientsPrevention programsClinical risk factorsDementiaClinical participantsRisk scoreAlzheimer's diseaseBidirectional relationship between epigenetic age and stroke, dementia, and late-life depression
Rivier C, Szejko N, Renedo D, Clocchiatti-Tuozzo S, Huo S, de Havenon A, Zhao H, Gill T, Sheth K, Falcone G. Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression. Nature Communications 2025, 16: 1261. PMID: 39893209, PMCID: PMC11787333, DOI: 10.1038/s41467-024-54721-0.Peer-Reviewed Original ResearchThis study shows a bidirectional link between accelerated epigenetic aging and brain health events like stroke, dementia, and depression, supporting new prevention strategies for aging-related conditions.Polygenic Susceptibility to Diabetes and Poor Glycemic Control in Stroke Survivors
Demarais Z, Conlon C, Rivier C, Clocchiatti-Tuozzo S, Renedo D, Torres-Lopez V, Sheth K, Meeker D, Zhao H, Ohno-Machado L, Acosta J, Huo S, Falcone G. Polygenic Susceptibility to Diabetes and Poor Glycemic Control in Stroke Survivors. Neurology 2025, 104: e210276. PMID: 39889253, DOI: 10.1212/wnl.0000000000210276.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsStroke survivorsWorse glycemic controlPoor glycemic controlStroke patientsAssociated with worse glycemic controlGlycemic controlPolygenic risk scoresClinical management of stroke patientsAssociated with poor glycemic controlManagement of stroke patientsCross-sectional designGenetic association studiesUncontrolled diabetesSusceptibility to T2DMUK BiobankType 2 diabetes mellitusAdverse vascular outcomesRisk scoreAssociation studiesHemoglobin A1cSurvivorsVascular outcomesSusceptibility to diabetesStrokeDiabetes
2024
Genal: a Python toolkit for genetic risk scoring and Mendelian randomization
Rivier C, Clocchiatti-Tuozzo S, Huo S, Torres-Lopez V, Renedo D, Sheth K, Falcone G, Acosta J. Genal: a Python toolkit for genetic risk scoring and Mendelian randomization. Bioinformatics Advances 2024, 5: vbae207. PMID: 39776894, PMCID: PMC11706532, DOI: 10.1093/bioadv/vbae207.Peer-Reviewed Original ResearchCitationsConceptsPolygenic risk scoresMendelian randomizationMR analysisGenome-wide association studiesPRS computationRisk scoreGenetic association dataGenetic risk scoreGenetic epidemiological studiesMR-PRESSOAssociation studiesGenetic epidemiologyMultiple R packagesMR methodsAssociation dataR packageEpidemiological studiesComputational experimentsGenalePython toolkitPython packageScoresPLINKComputation timeEpidemiologyCorrigendum: The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. Corrigendum: The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1502482. PMID: 39600788, PMCID: PMC11589155, DOI: 10.3389/fpsyt.2024.1502482.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
Activities
activity American Heart Association
08/24/2022 - PresentProfessional OrganizationsMemberactivity American Academy of Neurology
2022 - PresentProfessional OrganizationsMemberactivity American Geriatrics Society
11/30/2022 - PresentProfessional OrganizationsMemberactivity Gerontological Society of America
06/15/2023 - PresentProfessional OrganizationsMemberactivity Stroke, American Heart Association
2023 - PresentJournal ServiceReviewer
Honors
honor Futures in Neurologic Research Scholarship
04/13/2024National AwardAmerican Academy of Neurology (AAN)DetailsUnited Stateshonor Junior Investigator Travel Grant, International Stroke Conference
02/07/2024National AwardAmerican Heart AssociationDetailsUnited Stateshonor Butler-Williams Scholars Program
08/23/2023National AwardNational Institute on Aging (NIA), National Institutes of Health (NIH).DetailsUnited Stateshonor Bernard J. Tyson Career Development Award and Underrepresented Racial and Ethnic Groups Travel Grant
02/08/2023National AwardAmerican Heart AssociationDetailsUnited Stateshonor HEADS-UP: Health Equity and Actionable Disparities in Stroke Travel Award
02/08/2023National AwardAmerican Heart AssociationDetailsUnited States