Sandeep Kumar, PhD
Postdoctoral AssociateAbout
Research
Publications
2026
Synaptic and neural pathway redundancy enables the robustness of a sensory-motor reflex and promotes predation escape in Caenorhabditis elegans.
He H, Fong EKH, Kumar S, Lee HMT, Leifer AM, Chalfie M, Zheng C. Synaptic and neural pathway redundancy enables the robustness of a sensory-motor reflex and promotes predation escape in Caenorhabditis elegans. Proc Natl Acad Sci U S A 2026, 123: e2531407123. PMID: 42190007, DOI: 10.1073/pnas.2531407123.Peer-Reviewed Original ResearchExperience-Dependent Gain Modulation Drives Thermosensory Responses in Behavior.
García MD, Beagan J, Cabezas-Bou E, Thomas MJ, Kumar S, Shao L, Fu X, Cuentas-Condori A, McVay JR, Hawk JD, Lauziere A, Mohler W, Shroff H, Clark D, Colón-Ramos DA. Experience-Dependent Gain Modulation Drives Thermosensory Responses in Behavior. BioRxiv 2026 PMID: 42182155, DOI: 10.64898/2026.05.12.724589.Peer-Reviewed Original Research
2025
Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior
Kochersberger, Alison, et al. "Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior." bioRxiv (2025).Peer-Reviewed Original ResearchFunctional probing of neuronal subtypes via intersectional expression of optogenetic actuators reveals non-linear components in a linear circuit.
Li T, Kumar S, Poon H, Leifer AM, Zheng C. Functional probing of neuronal subtypes via intersectional expression of optogenetic actuators reveals non-linear components in a linear circuit. Cell Rep 2025, 44: 116327. PMID: 40975868, DOI: 10.1016/j.celrep.2025.116327.Peer-Reviewed Original ResearchDistributed control circuits across a brain-and-cord connectome.
Bates AS, Phelps JS, Kim M, Yang HH, Matsliah A, Ajabi Z, Perlman E, Delgado KM, Osman MAM, Salmon CK, Gager J, Silverman B, Renauld S, Collie MF, Fan J, Pacheco DA, Zhao Y, Patel J, Zhang W, Serratosa Capdevilla L, Roberts RJV, Munnelly EJ, Griggs N, Langley H, Moya-Llamas B, Maloney RT, Yu SC, Sterling AR, Sorek M, Kruk K, Serafetinidis N, Dhawan S, Stürner T, Klemm F, Brooks P, Lesser E, Jones JM, Pierce-Lundgren SE, Lee SY, Luo Y, Cook AP, McKim TH, Kophs EC, Falt T, Negrón Morales AM, Burke A, Hebditch J, Willie KP, Willie R, Popovych S, Kemnitz N, Ih D, Lee K, Lu R, Halageri A, Bae JA, Jourdan B, Schwartzman G, Demarest DD, Behnke E, Bland D, Kristiansen A, Skelton J, Stocks T, Garner D, Salman F, Daly KC, Hernandez A, Kumar S, BANC-FlyWire Consortium, Dorkenwald S, Collman F, Suver MP, Fenk LM, Pankratz MJ, Jefferis GSXE, Eichler K, Seeds AM, Hampel S, Agrawal S, Zandawala M, Macrina T, Adjavon DY, Funke J, Tuthill JC, Azevedo A, Seung HS, de Bivort BL, Murthy M, Drugowitsch J, Wilson RI, Lee WA. Distributed control circuits across a brain-and-cord connectome. BioRxiv 2025 PMID: 40766407, DOI: 10.1101/2025.07.31.667571.Peer-Reviewed Original ResearchDecoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution.
Haque R, Setty H, Lorenzo R, Stelzer G, Rotkopf R, Salzberg Y, Goldman G, Kumar S, Halber SN, Leifer AM, Schneidman E, Laurent P, Oren-Suissa M. Decoding sexual dimorphism of the sex-shared nervous system at single-neuron resolution. Sci Adv 2025, 11: eadv9106. PMID: 40644535, DOI: 10.1126/sciadv.adv9106.Peer-Reviewed Original ResearchNeural mechanisms of predictive processing: a collaborative community experiment through the OpenScope program
Aizenbud, Ido, et al. "Neural mechanisms of predictive processing: a collaborative community experiment through the OpenScope program." arXiv preprint arXiv:2504.09614 (2025).Peer-Reviewed Original Research
2024
Hierarchical behavior control by a single class of interneurons.
Huo J, Xu T, Liu Q, Polat M, Kumar S, Zhang X, Leifer AM, Wen Q. Hierarchical behavior control by a single class of interneurons. Proc Natl Acad Sci U S A 2024, 121: e2410789121. PMID: 39531495, DOI: 10.1073/pnas.2410789121.Peer-Reviewed Original ResearchNeuronal wiring diagram of an adult brain.
Dorkenwald S, Matsliah A, Sterling AR, Schlegel P, Yu SC, McKellar CE, Lin A, Costa M, Eichler K, Yin Y, Silversmith W, Schneider-Mizell C, Jordan CS, Brittain D, Halageri A, Kuehner K, Ogedengbe O, Morey R, Gager J, Kruk K, Perlman E, Yang R, Deutsch D, Bland D, Sorek M, Lu R, Macrina T, Lee K, Bae JA, Mu S, Nehoran B, Mitchell E, Popovych S, Wu J, Jia Z, Castro MA, Kemnitz N, Ih D, Bates AS, Eckstein N, Funke J, Collman F, Bock DD, Jefferis GSXE, Seung HS, Murthy M, FlyWire Consortium. Neuronal wiring diagram of an adult brain. Nature 2024, 634: 124-138. PMID: 39358518, DOI: 10.1038/s41586-024-07558-y.Peer-Reviewed Original ResearchWhole-brain annotation and multi-connectome cell typing of Drosophila.
Schlegel P, Yin Y, Bates AS, Dorkenwald S, Eichler K, Brooks P, Han DS, Gkantia M, Dos Santos M, Munnelly EJ, Badalamente G, Serratosa Capdevila L, Sane VA, Fragniere AMC, Kiassat L, Pleijzier MW, Stürner T, Tamimi IFM, Dunne CR, Salgarella I, Javier A, Fang S, Perlman E, Kazimiers T, Jagannathan SR, Matsliah A, Sterling AR, Yu SC, McKellar CE, FlyWire Consortium, Costa M, Seung HS, Murthy M, Hartenstein V, Bock DD, Jefferis GSXE. Whole-brain annotation and multi-connectome cell typing of Drosophila. Nature 2024, 634: 139-152. PMID: 39358521, DOI: 10.1038/s41586-024-07686-5.Peer-Reviewed Original Research