About
Titles
Hospital Resident
Departments & Organizations
Education & Training
- MD
- University of Connecticut School of Medicine (2020)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ryan Slovak's published research.
Publications Timeline
A big-picture view of Ryan Slovak's research output by year.
Hong-Jai Park
Insoo Kang, MD
Roy S. Herbst, MD, PhD
Scott Gettinger, MD
10Publications
178Citations
Publications
2021
Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer
Slovak RJ, Park HJ, Kamp WM, Ludwig JM, Kang I, Kim HS. Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer. Scientific Reports 2021, 11: 6956. PMID: 33772035, PMCID: PMC7997991, DOI: 10.1038/s41598-021-85810-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntigens, CDCD4-Positive T-LymphocytesCell Line, TumorCell ProliferationColorectal NeoplasmsCTLA-4 AntigenFemaleHepatitis A Virus Cellular Receptor 2Immune Checkpoint InhibitorsLymphocyte Activation Gene 3 ProteinLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred BALB CMicrosatellite RepeatsProgrammed Cell Death 1 ReceptorSpleenT-Lymphocytes, CytotoxicConceptsDual checkpoint inhibitionPD-1 inhibitionColorectal cancerCheckpoint inhibitionPD-1Checkpoint inhibitorsT cellsImmune responseRobust anti-tumor immune responseAnti-PD-1 groupAnti-PD-1 antibodyAnti-tumor immune responseMicrosatellite stable colorectal cancerDual PD-1Majority of patientsDeficient mismatch repairStable colorectal cancerCTLA-4 inhibitionTumor growth rateHigh microsatellite instabilityPotential escape mechanismsCombination immunotherapyImmunosuppressive checkpointsTumoral infiltrationDual therapy
2020
Adoptive Cell Therapy for Gastrointestinal Cancers
Slovak R, Kim H. Adoptive Cell Therapy for Gastrointestinal Cancers. Digestive Disease Interventions 2020, 04: 345-350. DOI: 10.1055/s-0040-1718902.Peer-Reviewed Original ResearchGenomics and Interventional Oncology in Primary Liver Cancer
Slovak R, Dendy Case M, Kim H. Genomics and Interventional Oncology in Primary Liver Cancer. Digestive Disease Interventions 2020, 04: 053-059. DOI: 10.1055/s-0040-1708533.Peer-Reviewed Original ResearchConceptsPrimary liver cancerLiver cancerInterventional oncologyForms of malignancyOncologic careInterventional oncologistsIntrahepatic cholangiocarcinomaHepatocellular carcinomaIndividual tumorsCancerPrecision medicineOncologyPersonalized medicineRadiogenomics researchRadiomicsMedicineCholangiocarcinomaCarcinomaMalignancyOncologistsTumorsCare3:00 PM Abstract No. 190 ■ FEATURED ABSTRACT Quantifying the immune response after combined immuno-thermal ablation in a murine model of colorectal cancer
Slovak R, Park H, Kamp W, Ludwig J, Kang I, Kim K. 3:00 PM Abstract No. 190 ■ FEATURED ABSTRACT Quantifying the immune response after combined immuno-thermal ablation in a murine model of colorectal cancer. Journal Of Vascular And Interventional Radiology 2020, 31: s87. DOI: 10.1016/j.jvir.2019.12.229.Peer-Reviewed Original ResearchQuantification of immune response after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer.
Kamp W, Park H, Slovak R, Ludwig J, Kang I, Kim H. Quantification of immune response after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer. Journal Of Clinical Oncology 2020, 38: 160-160. DOI: 10.1200/jco.2020.38.4_suppl.160.Peer-Reviewed Original ResearchConceptsDual immune checkpoint blockadeAnti-PD-1 antibodyColorectal cancerPD-1T cellsImmune responseMurine colorectal cancer cellsBALB/c miceDual checkpoint inhibitionExpression of TIM3Subcutaneous flank injectionNumber of CD8PD-1 inhibitionImmune checkpoint blockadeDeficient mismatch repairColorectal cancer cellsHigh microsatellite instabilitySignificant clinical impactPotential escape mechanismsCombination immunotherapyImmunosuppressive checkpointsCheckpoint inhibitorsMonotherapy groupCheckpoint blockadeMost patientsSystemic impact on tumor growth after combined immuno-thermal ablation in a murine model of colorectal cancer.
Slovak R, Park H, Kamp W, Ludwig J, Kang I, Kim H. Systemic impact on tumor growth after combined immuno-thermal ablation in a murine model of colorectal cancer. Journal Of Clinical Oncology 2020, 38: 198-198. DOI: 10.1200/jco.2020.38.4_suppl.198.Peer-Reviewed Original ResearchCitationsConceptsDual immune checkpoint blockadeTreatment days 0Target tumorTumor volumeDay 0Anti-cancer immune responseBALB/c miceAddition of immunotherapyImmune checkpoint blockadeTreatment day 2Colorectal cancer cellsInjection of antibodiesFull ablationCheckpoint blockadeColorectal cancerC miceSham injectionMean changeImmune responseMurine modelControl animalsCryoablationDay 2Tumor growthFlank injection
2019
In Regard to Jackson et al
Slovak R, Lu DS, Raja J, Arellano RS, Kim HS. In Regard to Jackson et al. International Journal Of Radiation Oncology • Biology • Physics 2019, 104: 695-696. PMID: 31162060, DOI: 10.1016/j.ijrobp.2019.03.005.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsInterventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies
Case M, Slovak R, Raja J, Kim H. Interventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies. Digestive Disease Interventions 2019, 03: 155-162. DOI: 10.1055/s-0039-1679936.Peer-Reviewed Original ResearchCitationsConceptsTranscatheter therapyImmune responseSystemic immunotherapyInterventional oncologyHepatic artery infusionImmunologic effectsTranscatheter embolizationTranscatheter treatmentTreatment paradigmMultiple malignanciesRadiation therapyTherapyImmunotherapyOncologyPotential effectsChemoembolizationEmbolizationResponseChemotherapyRadioembolizationMalignancyInfusionCancerInterventional Oncology in Immuno-Oncology Part 1: Thermal Ablation
Slovak R, Raja J, Case M, Kim H. Interventional Oncology in Immuno-Oncology Part 1: Thermal Ablation. Digestive Disease Interventions 2019, 03: 143-154. DOI: 10.1055/s-0039-1679935.Peer-Reviewed Original ResearchCitationsAltmetricConceptsImmune responseThermal ablationSitu tumor vaccineSystemic immunological effectsAnticancer immune responseAdaptive immune responsesFocused ultrasound ablationTumor vaccinesImmunological effectsAblative techniquesInterventional oncologyInvasive formUltrasound ablationAblationResponseMonotherapyPalliationImmunotherapyCryoablationMalignancyVaccineOncology
2017
Immuno-thermal ablations – boosting the anticancer immune response
Slovak R, Ludwig JM, Gettinger SN, Herbst RS, Kim HS. Immuno-thermal ablations – boosting the anticancer immune response. Journal For ImmunoTherapy Of Cancer 2017, 5: 78. PMID: 29037259, PMCID: PMC5644150, DOI: 10.1186/s40425-017-0284-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsImmune responseImmune effectsRobust antitumor responseAnticancer immune responseImmune modulating drugsUse of immunomodulationSystemic antitumor activityCheckpoint blockadeAntitumor responseAblative therapyCombination therapyRadiofrequency ablationAblative techniquesModulating drugsAnimal modelsAntitumor activityThermal ablationTherapeutic appealImmunomodulationTherapyAblationResponseMonotherapyImmunomodulatorsCryoablation
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