Robert Niescier
Associate Research ScientistAbout
Research
Publications
2025
All-optical visualization of specific molecules in the ultrastructural context of brain tissue
M’Saad O, Cairns A, Gulcicek J, Kasula R, Liao J, Kondratiuk I, Bewersdorf E, Kidd P, Falahati H, Gentile J, Niescier R, Watters K, Sterner R, Lee S, Guo X, Liu X, Desir G, De Camilli P, Rothman J, Koleske A, Biederer T, Kuan A, Bewersdorf J. All-optical visualization of specific molecules in the ultrastructural context of brain tissue. Nature Biotechnology 2025, 1-15. PMID: 41299044, DOI: 10.1038/s41587-025-02905-4.Peer-Reviewed Original ResearchA CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia
Elliott S, Ready P, Wrinn C, Ma Q, Edward M, Niescier R, Escobar I, Sun J, Ganga A, McAtee C, Atiş İ, Koleske A, Bordey A, Breslow D. A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia. Science Advances 2025, 11: eaeb7238. PMID: 41160700, PMCID: PMC12571082, DOI: 10.1126/sciadv.aeb7238.Peer-Reviewed Original Research
2022
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities
Prophet SM, Rampello AJ, Niescier RF, Gentile JE, Mallik S, Koleske AJ, Schlieker C. Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities. Nature Cell Biology 2022, 24: 1630-1641. PMID: 36302970, PMCID: PMC10041656, DOI: 10.1038/s41556-022-01001-y.Peer-Reviewed Original Research
2021
The Potential Role of AMPA Receptor Trafficking in Autism and Other Neurodevelopmental Conditions
Niescier R, Lin Y. The Potential Role of AMPA Receptor Trafficking in Autism and Other Neurodevelopmental Conditions. Neuroscience 2021, 479: 180-191. PMID: 34571086, DOI: 10.1016/j.neuroscience.2021.09.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRegulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism
Frei J, Niescier R, Bridi M, Durens M, Nestor J, Kilander M, Yuan X, Dykxhoorn D, Nestor M, Huang S, Blatt G, Lin Y. Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism. ENeuro 2021, 8: eneuro.0066-21.2021. PMID: 34135003, PMCID: PMC8266214, DOI: 10.1523/eneuro.0066-21.2021.Peer-Reviewed Original Research
2020
Development of a 3-D Organoid System Using Human Induced Pluripotent Stem Cells to Model Idiopathic Autism
Lunden J, Durens M, Nestor J, Niescier R, Herold K, Brandenburg C, Lin Y, Blatt G, Nestor M. Development of a 3-D Organoid System Using Human Induced Pluripotent Stem Cells to Model Idiopathic Autism. Advances In Neurobiology 2020, 25: 259-297. PMID: 32578151, DOI: 10.1007/978-3-030-45493-7_10.ChaptersTomosyn regulates the small RhoA GTPase to control the dendritic stability of neurons and the surface expression of AMPA receptors
Shen W, Kilander M, Bridi M, Frei J, Niescier R, Huang S, Lin Y. Tomosyn regulates the small RhoA GTPase to control the dendritic stability of neurons and the surface expression of AMPA receptors. Journal Of Neuroscience Research 2020, 98: 1213-1231. PMID: 32133675, PMCID: PMC7216846, DOI: 10.1002/jnr.24608.Peer-Reviewed Original ResearchHigh-throughput screening of human induced pluripotent stem cell-derived brain organoids
Durens M, Nestor J, Williams M, Herold K, Niescier R, Lunden J, Phillips A, Lin Y, Dykxhoorn D, Nestor M. High-throughput screening of human induced pluripotent stem cell-derived brain organoids. Journal Of Neuroscience Methods 2020, 335: 108627. PMID: 32032714, DOI: 10.1016/j.jneumeth.2020.108627.Peer-Reviewed Original Research
2018
MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons
Niescier R, Hong K, Park D, Min K. MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons. Journal Of Neuroscience 2018, 38: 4666-4677. PMID: 29686046, PMCID: PMC6596018, DOI: 10.1523/jneurosci.0504-18.2018.Peer-Reviewed Original Research
2016
Dynamics of Mitochondrial Transport in Axons
Niescier R, Kwak S, Joo H, Chang K, Min K. Dynamics of Mitochondrial Transport in Axons. Frontiers In Cellular Neuroscience 2016, 10: 123. PMID: 27242435, PMCID: PMC4865487, DOI: 10.3389/fncel.2016.00123.Peer-Reviewed Original Research