Robert Jacoby, DVM, PhD
Professor Emeritus of Comparative MedicineCards
Appointments
Comparative Medicine
Primary
Titles
Chief, Clinical Services, Yale Animal Resources Center
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Titles
Chief, Clinical Services, Yale Animal Resources Center
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
Appointments
Comparative Medicine
Primary
Titles
Chief, Clinical Services, Yale Animal Resources Center
Contact Info
Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States
About
Titles
Professor Emeritus of Comparative Medicine
Chief, Clinical Services, Yale Animal Resources CenterAppointments
Comparative Medicine
EmeritusPrimary
Other Departments & Organizations
Education & Training
- PhD
- Ohio State University (1969)
- DVM
- Cornell University (1963)
- Postdoctoral Fellow
- University of Chicago
Research
Research at a Glance
Publications Timeline
A big-picture view of Robert Jacoby's research output by year.
7Publications
115Citations
Publications
2004
Persistent Seoul virus infection in Lewis rats
Compton SR, Jacoby RO, Paturzo FX, Smith AL. Persistent Seoul virus infection in Lewis rats. Archives Of Virology 2004, 149: 1325-1339. PMID: 15221534, PMCID: PMC7087218, DOI: 10.1007/s00705-004-0294-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntibodies, ViralBrainCells, CulturedDisease ReservoirsEndothelial CellsHantavirus InfectionsHemorrhagic Fever with Renal SyndromeHyperglycemiaIn Situ HybridizationIslets of LangerhansKidneyLiverLungMuscle, Smooth, VascularMyocytes, Smooth MusclePancreasRatsRats, Inbred LewReverse Transcriptase Polymerase Chain ReactionRNA, ViralSalivary GlandsSeoul virusSkinSpleenConceptsSeoul virus infectionVirus infectionDays of ageLewis ratsClinical signsPersistent infectionSeoul virusViral RNAEndothelial cellsVascular smooth muscleVero E6 cellsSmooth muscle cellsCultured rat smooth muscle cellsRat smooth muscle cellsCultured endothelial cellsHantavirus persistencePancreatic infectionAssociated hyperglycemiaCommon siteSmooth muscleAnimal modelsHost cell typesE6 cellsExperimental infectionInfectious virus
2002
Immune Responses to the Major Capsid Protein during Parvovirus Infection of Rats
Ball-Goodrich LJ, Paturzo FX, Johnson EA, Steger K, Jacoby RO. Immune Responses to the Major Capsid Protein during Parvovirus Infection of Rats. Journal Of Virology 2002, 76: 10044-10049. PMID: 12208983, PMCID: PMC136518, DOI: 10.1128/jvi.76.19.10044-10049.2002.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsRV infectionImmune responseAdult ratsRat virusTh1-mediated immunityGamma interferon productionHost immune systemPerinatal infectionViral clearanceHumoral responseParvovirus infectionPersistent infectionImmune systemExperimental infectionInterferon productionInfectionRatsCapsid proteinLaboratory rodentsCellular responsesResponseMajor capsid proteinImmunityClearance
2001
Prevalence of rat virus infection in progeny of acutely or persistently infected pregnant rats.
Jacoby RO, Ball-Goodrich L, Paturzo FX, Johnson EA. Prevalence of rat virus infection in progeny of acutely or persistently infected pregnant rats. Comparative Medicine 2001, 51: 38-42. PMID: 11926300.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsRat virus infectionRV infectionOronasal inoculationVirus infectionPersistent infectionProgeny of damsNon-immune damsEvidence of infectionSprague-Dawley damsContact sentinelsMaternal antibodiesPrenatal infectionSerologic testingPregnant ratsPrenatal exposureSD ratsHigh prevalenceWeek 15Infant ratsVirus isolationWeek 9Contact transmissionInfectionRatsPregnancy
1980
Protection of Mice from Lethal Flaviviral Encephalitis by Adoptive Transfer of Splenic Cells from Donors Infected with Live Virus
Jacoby R, Bhatt P, Schwartz A. Protection of Mice from Lethal Flaviviral Encephalitis by Adoptive Transfer of Splenic Cells from Donors Infected with Live Virus. The Journal Of Infectious Diseases 1980, 141: 617-624. PMID: 6989931, DOI: 10.1093/infdis/141.5.617.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSplenic cellsImmune splenic cellsRabbit antiserum to mouse thymocytesAmelioration of clinical diseaseCell-for-cell basisSusceptible to lethal challengeTransfer of splenic cellsLethal challengeBanzi virusViral replicationCongenic donor miceTransfer of protectionCell-for-cellProtection of miceLive virusFlaviviral infectionsC3H/He recipientsC3H/RV micePrevent viral replicationAdoptive transferDonor miceAdoptive immunityC3H/He miceDeath rateThymus cells
1979
T Cell-Mediated Cytotoxicity for L 929 Fibroblasts Infected with Banzi Virus (Flavivirus)
Sheets P, Schwartz A, Jacoby R, Bhatt P. T Cell-Mediated Cytotoxicity for L 929 Fibroblasts Infected with Banzi Virus (Flavivirus). The Journal Of Infectious Diseases 1979, 140: 384-391. PMID: 315440, DOI: 10.1093/infdis/140.3.384.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCytotoxicity of spleen cellsT cell-mediated cytotoxicityBanzi virusCell-mediated cytotoxicityC3H/RV miceSpecific cytotoxicityKiller cellsC3H/He miceSpleen cellsLethal infectionDecreased to background levelsVirus infectionViral inoculationFlaviviral encephalitisL-929 fibroblastsMiceCytotoxicityInfectionBanziCytotoxic activityDaysFibroblastsVirusC3H/RVCells
1976
Genetic Resistance to Lethal Flavivirus Encephalitis. I. Infection of Congenic Mice with Banzi Virus
Jacoby R, Bhatt P. Genetic Resistance to Lethal Flavivirus Encephalitis. I. Infection of Congenic Mice with Banzi Virus. The Journal Of Infectious Diseases 1976, 134: 158-165. PMID: 787444, DOI: 10.1093/infdis/134.2.158.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsResistance to lethal infectionC3H/RV miceStrains of miceC3H/He miceBanzi virusYield of virusLethal infectionIntraperitoneal inoculationAdult C3H/He miceIntracerebral inoculation of virusMice in vivoLesions of encephalitisImmunofluorescence staining patternTiters of virusInoculation of virusCongenic miceAdult miceLymphoid tissueViral antigensLethal encephalitisSelf-limitingStaining patternViral replicationWidespread necrosisMiceGenetic Resistance to Lethal Flavivirus Encephalitis. II. Effect of Immunosuppression
Bhatt P, Jacoby R. Genetic Resistance to Lethal Flavivirus Encephalitis. II. Effect of Immunosuppression. The Journal Of Infectious Diseases 1976, 134: 166-173. PMID: 787445, DOI: 10.1093/infdis/134.2.166.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsT cell-depleted miceMice treated with cyclophosphamideHemagglutination-inhibiting antibodiesBanzi virusViral antigensLethal infectionX-irradiated miceSublethal X-irradiationSpread of viral antigenGenetic resistanceTiters of virusDetectable hemagglutination-inhibition antibodyAverage survival timeT cellsImmunological factorsImmunosuppressed miceResistance to infectionLymphoid tissueCyclophosphamideSurvival timeMiceYield of virusMortality rateX-irradiationInfection
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- January 15, 2004
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- December 15, 1999
The mouse that roared
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Comparative Medicine
PO Box 208016
New Haven, CT 06520-8016
United States