Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsRichard Young, MD
Associate Clinical ProfessorAbout
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Titles
Medical Services Provider
Assoc Clin Prof Pediatrics & Neurology
Appointments
General Pediatrics
Associate Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- MD
- Yale University (1973)
Research
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Research at a Glance
Publications Timeline
A big-picture view of Richard Young's research output by year.
11Publications
166Citations
Publications
2025
CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs
Morelli E, Aktas-Samur A, Maisano D, Gao C, Favasuli V, Papaioannou D, De Nola G, Henninger J, Liu N, Turi M, Folino P, Vreux L, Cumerlato M, Chen L, Aifantis I, Fulciniti M, Anderson K, Lytton-Jean A, Gulla A, Young R, Samur M, Munshi N. CRISPR-Cas13d functional transcriptomics reveals widespread isoform-selective cancer dependencies on lncRNAs. Blood 2025, 146: 847-860. PMID: 40403231, DOI: 10.1182/blood.2025028746.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCRISPR-Cas13dMultiple myelomaTE-lncRNAsIsoform-specific functionsDiverse cancer cell linesMM patientsCancer cell linesCellular proteostasisSubcellular localizationTumor cellsClinical dataCancer transcriptomeCytosolic isoformEndoplasmic reticulumFunctional transcriptomeHeat shock proteinsCancer dependenciesMM-specificClinical relevanceAnimal modelsLong noncoding RNAsLncRNA transcriptomeTherapeutic potentialCharacterize hundredsTranscriptomeExploring the complexity of MECP2 function in Rett syndrome
Liu Y, Whitfield T, Bell G, Guo R, Flamier A, Young R, Jaenisch R. Exploring the complexity of MECP2 function in Rett syndrome. Nature Reviews Neuroscience 2025, 26: 379-398. PMID: 40360671, DOI: 10.1038/s41583-025-00926-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMethylated DNA binding protein MeCP2Neuronal gene regulationReview recent insightsChromatin structureTranscriptional regulationGene regulationInteraction hubProtein MeCP2Cofactor interactionsTranscription factorsEpigenetic regulationRett syndromeProteomic studiesDiverse processesMolecular mechanismsMeCP2 functionTherapeutic designMeCP2Neuronal functionRegulationModel systemNeurodevelopmental disordersRepressorChromatinMechanistic studiesProtein codes promote selective subcellular compartmentalization
Kilgore H, Chinn I, Mikhael P, Mitnikov I, Van Dongen C, Zylberberg G, Afeyan L, Banani S, Wilson-Hawken S, Lee T, Barzilay R, Young R. Protein codes promote selective subcellular compartmentalization. Science 2025, 387: 1095-1101. PMID: 39913643, PMCID: PMC12034300, DOI: 10.1126/science.adq2634.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein sequencesSubcellular compartmentsDiverse subcellular compartmentsProtein language modelsAmino acid sequenceProtein codingAcid sequenceSubcellular localizationDiverse proteinsHuman proteinsSubcellular compartmentalizationFolding codePathological mutationsCompartment localizationProteinSequenceCompartmentMutationsAminoNucleolusCompartmentalizationCells
2024
Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis
Gallagher M, Du W, Hazel K, Aydin Z, Cheng Y, Yuan B, Bell G, Young R, Jaenisch R, Corradin O. Epigenomics and single cell CRISPR screening to investigate the risk‐modifying role of microglia in Alzheimer’s disease and multiple sclerosis. Alzheimer's & Dementia 2024, 20: e093591. PMCID: PMC11710746, DOI: 10.1002/alz.093591.Peer-Reviewed Original ResearchCitationsConceptsSingle nucleotide polymorphismsRisk lociMS risk lociEnhancer landscapeSingle cell screeningCell type-specific enhancersGenome-wide association studiesMicroglia-specific enhancersH3K27ac ChIP-seqNeurodegenerative diseasesCell type-specificEx vivo microgliaSNP enrichmentChIP-seqHi-C.CRISPRi screenEnhancer/promoter interactionNoncoding regionsRNA-seqAssociation studiesCRISPR screensCRISPRiNucleotide polymorphismsSafe harbor locusCell screeningProteolethargy is a pathogenic mechanism in chronic disease
Dall'Agnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, Dall'Agnese G, Overholt K, Sagi I, Hannett N, Erb H, Corradin O, Chakraborty A, Lee T, Young R. Proteolethargy is a pathogenic mechanism in chronic disease. Cell 2024, 188: 207-221.e30. PMID: 39610243, PMCID: PMC11724756, DOI: 10.1016/j.cell.2024.10.051.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPathogenic signalsExcessive reactive oxygen speciesMobility phenotypeCellular functionsAffected proteinsPathogenic mechanismsReactive oxygen speciesCysteine residuesSpectra of proteinsProtein mobilityPathogenic stimuliPathogenic featuresOxygen speciesMolecular levelCellular mechanismsDiverse chronic diseasesProteinChronic diseasesAn RNA-centric view of transcription and genome organization
Henninger J, Young R. An RNA-centric view of transcription and genome organization. Molecular Cell 2024, 84: 3627-3643. PMID: 39366351, PMCID: PMC11495847, DOI: 10.1016/j.molcel.2024.08.021.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGene regulationGenome architectureTranscriptional regulationModel of transcriptional regulationAssembly of protein complexesAssembly of transcription complexesLocal genome architectureSilencing of genesGenomic compartmentsGenome organizationGenomic structureRNA polymeraseChromatin regulationTranscription complexActive genesProtein complexesRNA moleculesTranscription factorsGenomeProtein kinaseSpecific genesGenesFeedback regulationRNASpatial compartmentsRNA and condensates: Disease implications and therapeutic opportunities
Han T, Portz B, Young R, Boija A, Klein I. RNA and condensates: Disease implications and therapeutic opportunities. Cell Chemical Biology 2024, 31: 1593-1609. PMID: 39303698, DOI: 10.1016/j.chembiol.2024.08.009.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRegulate key cellular processesDiverse RNA speciesRNA speciesTarget RNACompartmentalizing proteinsCellular processesRNA moleculesMembraneless organellesRNA roleBiomolecular condensatesRNA-based therapiesComplex diseasesRNA abnormalitiesRNADisease pathogenesisCondensate formationProperties of condensatesTherapeutic strategiesSmall moleculesOrganellesMislocalizationOverexpressionProteinSpeciesNeurological disordersMECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons
Liu Y, Flamier A, Bell G, Diao A, Whitfield T, Wang H, Wu Y, Schulte F, Friesen M, Guo R, Mitalipova M, Liu X, Vos S, Young R, Jaenisch R. MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. Neuron 2024, 112: 1943-1958.e10. PMID: 38697112, DOI: 10.1016/j.neuron.2024.04.007.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPromoter-proximal regionRNA polymerase IIPolymerase IIHuman neuronsMethylated DNA binding protein MeCP2RNA Pol IIWild-typeLoss of gene activityAutism risk genesPol IIPositive cofactorCpG islandsTranscriptional regulationModulate transcriptionProtein MeCP2Patient mutationsNeurodevelopmental disorder Rett syndromeGene activationRisk genesProteomic analysisNeuronal genesRett syndromeGene expressionGenesRNA
2023
TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation
Rossmann M, Yang S, Abraham B, Wang Y, Young R, Hekimi S, Zon L. TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation. Blood 2023, 142: 8. DOI: 10.1182/blood-2023-184853.Peer-Reviewed Original ResearchConceptsTranscription elongationErythroid differentiationErythroid lineageNucleotide metabolismHematopoietic stem cell differentiationCell fate decisionsGenome-wide expressionChromatin immunoprecipitation analysisOnset of hematopoiesisTranscription regulatory processesErythroid progenitor differentiationStem cell differentiationElectron transport chainInhibitor of ferroptosisTranscriptional intermediary factor 1 gammaEnzyme dihydroorotate dehydrogenaseChromatin factorsSuppressor screenMutant embryosFate decisionsTranscriptome profilingZebrafish embryosProgenitor differentiationLineage differentiationBlood differentiation
1990
Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II Subunits
Scafe C, Martin C, Nonet M, Podos S, Okamura S, Young R. Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II Subunits. Molecular And Cellular Biology 1990, 10: 1270-1275. DOI: 10.1128/mcb.10.3.1270-1275.1990.Peer-Reviewed Original ResearchConceptsRNA polymerase II largest subunitRNA polymerase mutantsAmino acid residuesRPB1 geneLarge subunitInvariant residuesEucaryotic organismsPolymerase mutantsConditional mutationsYeast cellsSequence analysisAcid residuesRPB2RPB1MutationsCold sensitivityResiduesYeastMutantsCellsHomologyPlasmidGenesRNASubunit