Richa Sharma, MD, MPH
Associate Professor of NeurologyDownloadHi-Res Photo
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Titles
Associate Professor of Neurology
Biography
Dr.Richa Sharma is a vascular neurologist who specializes in prevention and treatment of ischemic and hemorrhagic strokes. She trained in neurology as a resident at Johns Hopkins Hospital and in vascular neurology at Massachusetts General Hospital as a fellow. She was also selected as the StrokeNet Research Fellow at the Massachusetts General Hospital. Her research interests revolve around applying novel computational techniques to identify the underlying causes of stroke in individual patients. She is also interested in cardioembolic sources of stroke.
Last Updated on November 19, 2024.
Appointments
Neurology
Associate Professor on TermPrimary
Other Departments & Organizations
- All Institutions
- Center for Brain & Mind Health
- Center for Neuroepidemiology and Clinical Neurological Research
- Janeway Society
- Neurology
- Vascular Neurology
- Yale Biomedical Imaging Institute
- Yale Medicine
- Yale New Haven Health System
Education & Training
- StrokeNet Research Fellowship
- Massachusetts General Hospital (2019)
- Vascular Neurology Fellowship
- Massachusetts General Hospital (2018)
- Neurology Residency
- Johns Hopkins Hospital (2017)
- Internship
- Johns Hopkins Hospital (2014)
- MD
- Duke University School of Medicine (2013)
- MPH
- Yale School of Public Health (2009)
- BA
- Cornell University, Neurobiology and Behavior; Economics (2007)
Research
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Overview
Medical Research Interests
Ischemic Stroke; Treatment Adherence and Compliance
ORCID
0000-0003-0798-2353
Research at a Glance
Yale Co-Authors
Frequent collaborators of Richa Sharma's published research.
Publications Timeline
A big-picture view of Richa Sharma's research output by year.
Research Interests
Research topics Richa Sharma is interested in exploring.
Adam de Havenon, MD, MS
Kevin Sheth, MD, FAHA
Guido J. Falcone, ScD, MPH
Cyprien Rivier, MD, MSc
Harlan Krumholz, MD, SM
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
55Publications
401Citations
Ischemic Stroke
Publications
2026
Recurrent Stroke in Patients With Cryptogenic Stroke and Left Ventricular Injury: The Cardiac Abnormalities in Stroke Prevention and Recurrence (CASPR) Study.
Sharma R, McNamara K, Badillo Goicoechea E, Bowman A, Van Coevering R, Chen L, Penckofer M, Singh E, Kerrigan D, Aboul-Nour H, Nahab F, Glover P, Krishnaiah B, Yaghi S, Khasiyev F, Lineback C, Melkumova E, Culbertson C, Nguyen T, Thompson S, Jillella D, Daniel J, Aziz Y, Alvi M, Herpich F, Shahrivari M, Chionatos R, Elangovan C, Kang J, Zha A, Farooqui M, Rothstein A, Khan F, Smith M, Brown S, Abu Qdais A, Liebeskind D, Abburi N, Rozental S, Nedelcu S, Thon J, Stretz C, Thottempudi N, Yu W, Eklund K, Linares G, de Havenon A, Siegler J. Recurrent Stroke in Patients With Cryptogenic Stroke and Left Ventricular Injury: The Cardiac Abnormalities in Stroke Prevention and Recurrence (CASPR) Study. Stroke 2026 PMID: 41766531, DOI: 10.1161/strokeaha.125.053755.Peer-Reviewed Original ResearchAltmetricConceptsLV ejection fractionWall motion abnormalitiesPotential cardioembolic sourcesMajor bleedingEjection fractionRecurrent strokeAntiplatelet therapyRetrospective studyMotion abnormalitiesCardiac abnormalitiesLeft ventricular (LV) dysfunctionPrimary outcomeCryptogenic strokeStroke preventionIschemic strokeLeft ventricular injuryCox proportional hazards modelsAssociated with lower ratesTreatment effect modificationRisk of recurrent strokeInjury subgroupsRecurrent ischemic strokeProportional hazards modelRecurrent stroke riskRecurrence cohort
2025
Unraveling disparities in county‐level dementia diagnosis prevalence across the United States
de Havenon A, Littig L, Falcone G, Sharma R, Fesharaki A, Yaghi S, Calvario E, Rosand J, Sheth K, Anderson C. Unraveling disparities in county‐level dementia diagnosis prevalence across the United States. Alzheimer's & Dementia 2025, 21: e70954. PMID: 41404852, PMCID: PMC12709554, DOI: 10.1002/alz.70954.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDiagnosis prevalenceDementia diagnosisFast foodFast food accessImpact of targeted interventionsHigher diabetes prevalenceUninsured rateCounty-level variablesCounty-level variationDementia casesDiabetes prevalenceUnited StatesSmoking ratesHigh-burden communitiesMedicare beneficiariesHigher diabetesPrevention strategiesDementiaLogistic regressionPrevalenceBackward selectionLarger householdsHousehold sizePredictorsCountyIntracranial Occlusion in Cryptogenic Stroke Is Not Predictive of Recurrent Ischemic Stroke: A Propensity‐Score Matched Analysis of the Cardiac Abnormalities in Stroke Prevention and Risk of Recurrence Study
Smith M, Brorson J, Goicoechea E, Penckofer M, Eklund K, Stretz C, Lineback C, Khasiyev F, Kerrigan D, Lewis S, Ali H, Aboul‐Nour H, de Havenon A, Culbertson C, Melkumova E, Jillella D, Dumitrascu O, Parikh P, Doolittle C, Yahnke I, Sathya A, Brown S, Kang J, Bowman A, Shahrivari M, Elangovan C, Sehgal S, Sloane K, Alvi M, Krishnaiah B, Kam W, Kothari S, Abu Qdais A, Farooqui M, Nahab F, Quintela G, Sharma R, Thottempudi N, Nedelcu S, Herpich F, Glover P, Chahien D, Liebeskind D, Linares G, Daniel J, Al Kasab S, Singh E, D'Souza M, Gaudio E, Aziz Y, Yaghi S, Kala N, Sarkar M, Goldstein E, Chen L, Van Coevering R, Thon J, Stamm B, Thompson S, Siegler J. Intracranial Occlusion in Cryptogenic Stroke Is Not Predictive of Recurrent Ischemic Stroke: A Propensity‐Score Matched Analysis of the Cardiac Abnormalities in Stroke Prevention and Risk of Recurrence Study. Journal Of The American Heart Association 2025, 14: e041500. PMID: 40996035, PMCID: PMC12684489, DOI: 10.1161/jaha.125.041500.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsRate of recurrent strokePrimary outcomeMulticenter retrospective cohortRecurrent strokeIntracranial occlusionRetrospective cohort of adultsCohort of adultsCox proportional hazards modelsRecurrent ischemic strokeVascular risk factorsHigh-risk sourceEmbolic strokePropensity score matchingIschemic strokeProportional hazards modelCerebral microvascular diseaseCryptogenic strokeRisk of recurrenceScore matchingPropensity-score matching analysisMatching AnalysisSources of embolismHazards modelRisk factorsStroke preventionApixaban and Recurrent Stroke Risk With Left Ventricular Dysfunction: A Secondary Analysis of the ARCADIA Trial
Sharma R, Jillella D, Zhang C, Elkind M, Kamel H, Di Tullio M, Kronmal R, Krishnaiah B, Yaghi S, Longstreth W, Tirschwell D, Merkler A, Nahab F. Apixaban and Recurrent Stroke Risk With Left Ventricular Dysfunction: A Secondary Analysis of the ARCADIA Trial. Stroke 2025, 56: 3118-3126. PMID: 40891365, PMCID: PMC12707556, DOI: 10.1161/strokeaha.125.052724.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLV systolic dysfunctionRecurrent ischemic strokeSystolic dysfunctionCox proportional hazards modelsRisk of recurrent ischemic strokeProportional hazards modelPost Hoc AnalysisSecondary stroke preventionIschemic strokeLeft ventricular (LV) systolic dysfunctionLV ejection fraction <LV wall motion abnormalitiesPost hoc analysis of dataStroke preventionHazards modelEjection fraction <LV fractional shorteningOptimal antithrombotic therapyLeft ventricular dysfunctionStroke riskRecurrent strokeWall motion abnormalitiesAssociated with recurrent strokeARCADIA trialSecondary analysisAssociation of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors
Wu K, Huo S, Rivier C, Torres-Lopez V, Sharma R, de Havenon A, Worrall B, Sheth K, Falcone G. Association of Polygenic Susceptibility to Hyperlipidemia With Cholesterol Control and Recurrent Stroke in Ischemic Stroke Survivors. Neurology 2025, 105: e213966. PMID: 40825160, PMCID: PMC13014709, DOI: 10.1212/wnl.0000000000213966.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsIschemic stroke survivorsStroke survivorsAssociated with riskSusceptible to hyperlipidemiaHigh riskUK BiobankResistant hyperlipidemiaCholesterol controlUncontrolled hyperlipidemiaSurvivors of ischemic strokeHigher risk of recurrent vascular eventsPolygenic risk scoresRisk factor controlRisk of recurrent vascular eventsAdverse genetic profileLow-density lipoprotein cholesterolRisk of acute coronary eventsGenetic association studiesRecurrent strokeClinical trajectoryGenetic risk variantsRisk of recurrent strokeAcute ischemic stroke survivorsPolygenic profilePrecision medicine toolsComparing Claims Data to Stroke and Bleeding in the NCDR Left Atrial Appendage Occlusion Registry
Faridi K, Freeman J, Wang Y, Pereira L, Zimmerman S, Friedman D, Sharma R, Higgins A, Mortazavi B, Ross J, Krumholz H, Yeh R, Curtis J. Comparing Claims Data to Stroke and Bleeding in the NCDR Left Atrial Appendage Occlusion Registry. JACC Advances 2025, 4: 102019. PMID: 40712270, PMCID: PMC12311505, DOI: 10.1016/j.jacadv.2025.102019.Peer-Reviewed Original ResearchConceptsInternational ClassificationPositive predictive valueClaims dataRegistry dataIncidence rateNational Cardiovascular Data Registry LAAO RegistryGastrointestinal bleedingIntracranial hemorrhageHemorrhagic strokeBleeding eventsIschemic strokePostmarketing surveillanceTranscatheter left atrial appendage occlusionInpatient hospitalizationSurveillance of therapyRevision codesMajor bleeding eventsNegative predictive valueKappa statisticRegistryRegistry patientsModerate agreementEstimates of sensitivityMajor bleedingAppendage occlusionE-090 Acute ischemic stroke risk following cardiac interventions in the United States from 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. E-090 Acute ischemic stroke risk following cardiac interventions in the United States from 2016 to 2021. 2025, a153-a155. DOI: 10.1136/jnis-2025-snis.206.Peer-Reviewed Original ResearchOutcomes of Patients With Embolic Stroke of Undetermined Source Treated With Antiplatelet Agents or Anticoagulation
Siegler J, Goicoechea E, Penckofer M, Eklund K, Yaghi S, Stretz C, Lineback C, Stamm B, Peter S, D'Souza M, Conyers F, Khasiyev F, Kerrigan D, Lewis S, Ali H, Aboul-Nour H, Sharma R, Nahab F, Glover P, Thompson S, Alshaer Q, Thottempudi N, de Havenon A, Culbertson C, Melkumova E, Chionatos R, Jillella D, Daniel J, Ro J, Frankel M, Dumitrascu O, Brown S, Parikh P, Doolittle C, Yahnke I, Sathya A, Kang J, Kirchhoffer K, Bowman A, Smith M, Brorson J, Asabere A, Shahrivari M, Elangovan C, Sheibani N, Krishnaiah B, Gaudio E, Sloane K, Rothstein A, Alvi M, Annam S, Amankwah C, Kam W, Abburi N, Farooqui M, Rojas-Soto D, Molaie A, Khezri N, Zubair A, Abbasi M, Van Coevering R, Chen L, Nedelcu S, Herpich F, Chahien D, Sehgal S, Liebeskind D, Linares G, Zha A, Sarkar M, Xi R, Nelson A, Abu Qdais A, Al Kasab S, Singh E, Patel V, Aziz Y, Mehndiratta P, DeMarco A, Sharrief A, Cucchiara B, Salehi Omran S, Nguyen T, Dubinski M, Ackerman J, Thon J. Outcomes of Patients With Embolic Stroke of Undetermined Source Treated With Antiplatelet Agents or Anticoagulation. Neurology 2025, 105: e213876. PMID: 40609061, DOI: 10.1212/wnl.0000000000213876.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInverse probability of treatment weightingPotential embolic sourcesBenefits of anticoagulationLeft ventricular injuryEmbolic sourceEmbolic strokeMajor bleedingAntiplatelet therapyVentricular injuryComposite outcomeMedian NIH Stroke Scale scoreCohort studyRecurrent strokePrimary outcomePatients treated with anticoagulantsRetrospective observational cohort studyIschemic strokeTreated with anticoagulationConsecutive adult patientsRisk of recurrenceOutcomes of patientsCox proportional hazards regressionInverse probabilityNIH Stroke Scale scoreProbability of treatment weightingAcute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. Acute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021. Neurology 2025, 105: e213766. PMID: 40493873, PMCID: PMC12165311, DOI: 10.1212/wnl.0000000000213766.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntervention hospitalsSurvey weightsNon-Hispanic black ethnicityNIH Stroke ScaleStroke riskIschemic strokeFactors associated with ischemic strokeAssociated with female sexCardiac interventionsIschemic stroke riskIncidence of ischemic strokeVariables associated with riskRate of ischemic strokeNational Inpatient SampleHigh-risk populationDiagnosis-related groupsIntervention patientsCross-sectional cohortUnited StatesAcute ischemic stroke riskIn-Hospital DeathRisk of strokeSecondary analysisBlack ethnicityInpatient mortalityLeft Ventricular Injury Detected by Cardiac MRI and Incident Ischemic Stroke and Dementia Risk
Sharma R, Hansen S, Merkler A, Lima J, Longstreth W. Left Ventricular Injury Detected by Cardiac MRI and Incident Ischemic Stroke and Dementia Risk. Neurology 2025, 104: e213606. PMID: 40249894, PMCID: PMC12012626, DOI: 10.1212/wnl.0000000000213606.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIncident ischemic strokeAssociated with incident ischemic strokeMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStroke-free participantsMI cohortMultiple imputationNewly diagnosed dementiaObservational cohortIschemic strokeRates of cardiovascular diseasePopulation-based cohortStudy of atherosclerosisCohort of participantsCox proportional hazards modelsDementia riskInjury riskProportional hazards modelPrimary exposureDementiaBrain healthPrimary outcomeHazards modelCardiovascular diseaseParticipants
Clinical Trials
Current Trials
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
IRB ID2000031893RoleSub InvestigatorPrimary Completion Date03/07/2028Recruiting ParticipantsGenderBothAge30 years - 80 yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
IRB ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
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Activities
activity Stroke
2019 - PresentJournal ServiceRevieweractivity Neurology
2019 - PresentJournal ServiceRevieweractivity Circulation
2019 - PresentJournal ServiceRevieweractivity American Heart Association/American Stroke Association
2017 - PresentProfessional OrganizationsMemberactivity American Academy of Neurology
2017 - PresentProfessional OrganizationsMember
Honors
honor Selected NIH StrokeNet Educational Core Trainee Representative
10/06/2020National AwardDetailsUnited Stateshonor Record Annual Telestroke Volume, Massachusetts General Hospital
10/06/2020Other AwardDetailsUnited Stateshonor Record Annual IV-tPA Volume, Massachusetts General Hospital
06/30/2018Other AwardDetailsUnited Stateshonor Vice Dean’s Clinical Science Research Award
06/01/2012Other AwardDetailsUnited Stateshonor Eugene A. Stead Research Scholarship
05/02/2011Other AwardDetailsUnited States
Clinical Care
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Overview
Richa Sharma, MD, MPH, is a vascular neurologist who specializes in prevention and treatment of ischemic and hemorrhagic strokes. She trained in neurology as a resident at Johns Hopkins Hospital and in vascular neurology at Massachusetts General Hospital as a fellow. Dr. Sharma was also selected as the StrokeNet Research Fellow at the Massachusetts General Hospital. Her research interests include applying novel computational techniques to identify the underlying causes of stroke in individual patients. She is also interested in cardioembolic sources of stroke.
Clinical Specialties
Stroke; Neurology
Fact Sheets
Ischemic Stroke
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