Rebecka Hoffman
Assistant Professor of Emergency MedicineCards
About
Research
Publications
2021
Chronic Exercise Mitigates the Effects of Sirtuin Inhibition by Salermide on Endothelium-Dependent Vasodilation
Harris M, Hoffman R, Olesiak M. Chronic Exercise Mitigates the Effects of Sirtuin Inhibition by Salermide on Endothelium-Dependent Vasodilation. Cardiovascular Toxicology 2021, 21: 790-799. PMID: 34185244, DOI: 10.1007/s12012-021-09669-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaEndothelium, VascularHistone Deacetylase InhibitorsMaleNaphtholsNitric Oxide Synthase Type IIIOxidative StressPhenylpropionatesPhysical Conditioning, AnimalPhysical EnduranceRatsRats, WistarRunningSignal TransductionSirtuin 1Superoxide DismutaseTime FactorsTyrosineVasodilationConceptsChronic endurance trainingEndothelial functionMotor-driven treadmillInfluence of exerciseDose-responses to phenylephrineResponse to phenylephrineEndothelium-dependent vasodilationEndothelium-dependent relaxationEndurance trainingENOS protein expressionExercise trainingMale Wistar ratsRegulation of endothelial functionSIRT1 expressionEndothelium-DependentRat aortaExerciseVascular reactivityNitrotyrosine levelsWistar ratsRegulation of eNOSENOS expressionSodium nitroprussideSirtuin inhibitionProtein expression
2013
Effects of vitamin E supplementation and exercise on endothelial function in rat aortas
Hoffman R, Olesiak M, Harris M. Effects of vitamin E supplementation and exercise on endothelial function in rat aortas. The FASEB Journal 2013, 27: lb661-lb661. DOI: 10.1096/fasebj.27.1_supplement.lb661.Peer-Reviewed Original ResearchChronic endurance exerciseEndurance exerciseAcute endurance exerciseEndothelial dependent dilationMotor-driven treadmillVitamin E supplementationExercise groupAcute exerciseChronic exerciseDose-response curves to phenylephrineExerciseE supplementationACh-induced vasorelaxationEndothelium-dependent relaxationEndothelium-dependent vasorelaxationVitamin ERat aortaEndothelial functionWistar ratsENOS expressionSodium nitroprussideVascular functionEffect of vitamin E supplementationDependent relaxationRats