Raman Nelakanti
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Biography
Professional: I am an 8th year MD-PhD student at the Yale School of Medicine. For my PhD thesis under the mentorship of Prof. Andrew Xiao in the Dept. of Genetics, I studied the function of a newly discovered epigenetic mark, DNA N(6)-methyladenine, in stem cell fate decisions during trophoblast development and hematopoiesis. I am interested in pursuing a physician-scientist career at the intersection of epigenetics, stem cell biology, and human disease.
Hobbies: Hiking, Biking, A Cappella, Cricket
Last Updated on November 14, 2023.
Education & Training
- BS
- Stanford University, Bioengineering (2014)
Research
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Overview
Medical Research Interests
DNA Methylation; Embryonic Stem Cells; Epigenomics; Hematopoiesis
ORCID
0000-0002-2085-4236
Research at a Glance
Yale Co-Authors
Frequent collaborators of Raman Nelakanti's published research.
Publications Timeline
A big-picture view of Raman Nelakanti's research output by year.
Research Interests
Research topics Raman Nelakanti is interested in exploring.
Andrew Xiao, PhD
Stephanie Halene, MD, Dr Med
Akiko Iwasaki, PhD
Alexa Siddon, MD
Francine Foss, MD
Giulia Biancon, PhD
8Publications
708Citations
Embryonic Stem Cells
Hematopoiesis
Publications
2025
Impact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant
VanOudenhove J, Liu Y, Nelakanti R, Kim D, Busarello E, Ovalle N, Qi Z, Mamillapalli P, Siddon A, Bai Z, Axtmayer A, Corso C, Kothari S, Foss F, Isufi I, Tebaldi T, Gowda L, Fan R, Seropian S, Halene S. Impact of memory T cells on SARS-CoV-2 vaccine response in hematopoietic stem cell transplant. PLOS ONE 2025, 20: e0320744. PMID: 40294012, PMCID: PMC12036906, DOI: 10.1371/journal.pone.0320744.Peer-Reviewed Original ResearchCitations
2020
A New Link to Primate Heart Development
Nelakanti RV, Xiao AZ. A New Link to Primate Heart Development. Developmental Cell 2020, 54: 685-686. PMID: 32991832, DOI: 10.1016/j.devcel.2020.09.009.Commentaries, Editorials and LettersCitationsAltmetricN6-methyladenine in DNA antagonizes SATB1 in early development
Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman MH, Guo C, Wang P, Zhang M, Jiang Z, Wang Y, Li H, Xiao AZ. N6-methyladenine in DNA antagonizes SATB1 in early development. Nature 2020, 583: 625-630. PMID: 32669713, PMCID: PMC8596487, DOI: 10.1038/s41586-020-2500-9.Peer-Reviewed Original ResearchCitationsAltmetricm6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity 2020, 52: 1007-1021.e8. PMID: 32497523, PMCID: PMC7408742, DOI: 10.1016/j.immuni.2020.05.003.Peer-Reviewed Original ResearchCitationsAltmetricMammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA
Zhang M, Yang S, Nelakanti R, Zhao W, Liu G, Li Z, Liu X, Wu T, Xiao A, Li H. Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA. Cell Research 2020, 30: 197-210. PMID: 32051560, PMCID: PMC7054317, DOI: 10.1038/s41422-019-0237-5.Peer-Reviewed Original ResearchCitationsAltmetric
2018
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo
Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC. Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo. Cell Stem Cell 2018, 22: 501-513.e7. PMID: 29456158, PMCID: PMC6134179, DOI: 10.1016/j.stem.2018.01.016.Peer-Reviewed Original ResearchCitationsAltmetric
2017
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
Kooreman NG, de Almeida PE, Stack JP, Nelakanti RV, Diecke S, Shao NY, Swijnenburg RJ, Sanchez-Freire V, Matsa E, Liu C, Connolly AJ, Hamming JF, Quax PHA, Brehm MA, Greiner DL, Shultz LD, Wu JC. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Reports 2017, 20: 1978-1990. PMID: 28834758, PMCID: PMC5573767, DOI: 10.1016/j.celrep.2017.08.003.Peer-Reviewed Original ResearchCitationsAltmetric
2015
Teratoma Formation: A Tool for Monitoring Pluripotency in Stem Cell Research
Nelakanti RV, Kooreman NG, Wu JC. Teratoma Formation: A Tool for Monitoring Pluripotency in Stem Cell Research. Current Protocols In Stem Cell Biology 2015, 32: 4a.8.1-4a.8.17. PMID: 25640819, PMCID: PMC4402211, DOI: 10.1002/9780470151808.sc04a08s32.Peer-Reviewed Original ResearchCitationsAltmetric
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