Qiao Wu
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2023
Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability
Zhang J, Wu Q, Hu X, Wang Y, Lu J, Chakraborty R, Martin K, Guo S. Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability. Stem Cells 2023, 41: 907-915. PMID: 37386941, PMCID: PMC11009695, DOI: 10.1093/stmcls/sxad051.Peer-Reviewed Original ResearchConceptsMouse pluripotent stem cellsSerum response factorPluripotent stem cellsCell fate stabilityRole of SRFGene expression noiseHeterogeneous gene expressionResponse factorStem cellsNaïve pluripotencyCell state heterogeneityLineage primingExpression noiseActin dynamicsCellular statesPluripotent cellsSRF functionCell statesMechanical signalingGene expressionFunctional modulationCentral mediatorSerum-containing culturesState heterogeneityCells
2021
Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer
Zhang B, Li Y, Wu Q, Xie L, Barwick B, Fu C, Li X, Wu D, Xia S, Chen J, Qian W, Yang L, Osunkoya A, Boise L, Vertino P, Zhao Y, Li M, Chen H, Kowalski J, Kucuk O, Zhou W, Dong J. Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nature Communications 2021, 12: 1714. PMID: 33731701, PMCID: PMC7969754, DOI: 10.1038/s41467-021-21976-w.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsAntineoplastic Combined Chemotherapy ProtocolsBenzylaminesBone NeoplasmsCarcinogenesisCell Line, TumorCyclamsDocetaxelEpithelial-Mesenchymal TransitionHumansInterleukin-11Kruppel-Like Transcription FactorsMaleMiceMutationOsteogenesisProstatic Neoplasms, Castration-ResistantReceptors, CXCR4Signal TransductionTransforming Growth Factor betaConceptsBone metastasesProstate cancerBone metastatic lesionsAdvanced prostate cancerPCa bone metastasisIL-11 secretionMetastatic lesionsMetastasisTranscription factor KLF5CXCR4Mesenchymal phenotypeUnderlying mechanismCancerKLF5TumorigenicityPlerixaforTherapyLesionsTumorsOsteoclastogenesisChemoresistanceTGFParacrineSecretionEMT
2020
Reprogramming progressive cells display low CAG promoter activity
Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, Eastman AE, Park I, Guo S. Reprogramming progressive cells display low CAG promoter activity. Stem Cells 2020, 39: 43-54. PMID: 33075202, PMCID: PMC7821215, DOI: 10.1002/stem.3295.Peer-Reviewed Original Research
2018
CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth
Wu Q, Fu C, Li M, Li J, Li Z, Qi L, Ci X, Ma G, Gao A, Fu X, A J, An N, Liu M, Li Y, King JL, Fu L, Zhang B, Dong JT. CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth. International Journal Of Cancer 2018, 144: 582-594. PMID: 30289973, PMCID: PMC6294659, DOI: 10.1002/ijc.31908.Peer-Reviewed Original ResearchConceptsKrüppel-like factor 5Effects of KLF5Nuclear proteinsNumber of genesCell cycle progressionTumor growthTSU-Pr1 cellsCell cycle regulator cyclin D1Cellular contextNovel cofactorTranscriptional targetsCaspase-7Cycle progressionCell growthCancer cell linesNovel therapeutic targetProteinPhysical interactionCell proliferationBladder cancer cell linesCell linesCyclin D1GenesFactor 5LC-MS/MSLEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway
Gao A, Sun T, Ma G, Cao J, Hu Q, Chen L, Wang Y, Wang Q, Sun J, Wu R, Wu Q, Zhou J, Liu L, Hu J, Dong J, Zhu Z. LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERα pathway. Nature Communications 2018, 9: 4180. PMID: 30301939, PMCID: PMC6177406, DOI: 10.1038/s41467-018-06309-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAurora Kinase ABreast NeoplasmsCarcinogenesisCell Line, TumorCell ProliferationCyclin DCyclin-Dependent KinasesDrug Resistance, NeoplasmEstrogen Receptor alphaFemaleG1 PhaseHumansMembrane ProteinsMice, NudeNuclear ProteinsPhosphorylationProtein BindingProtein StabilityRetinoblastoma ProteinS PhaseSignal TransductionSurvival AnalysisTamoxifenTranscriptional ActivationTreatment OutcomeConceptsBreast cancer cellsTamoxifen resistanceBreast cancerEstrogen receptor α (ERα) positive breast cancerPoor relapse-free survivalCancer cellsRelapse-free survivalPositive breast cancerBreast cancer therapeuticsEndocrine therapyERα pathwayPrognostic markerTumor growthFunctional antagonismG1/S phase transitionElevated levelsERαTherapeutic importanceS phase transitionTamoxifenCancer therapeuticsRb phosphorylationCancerAttractive targetMolecular events
2017
ERRF sensitizes ERBB2-positive breast cancer cells to lapatinib treatment likely by attenuating MCL1 and ERBB2 expression
Qi L, Zhang B, Zhang S, Ci X, Wu Q, Ma G, Luo A, Fu L, King J, Nahta R, Dong J. ERRF sensitizes ERBB2-positive breast cancer cells to lapatinib treatment likely by attenuating MCL1 and ERBB2 expression. Oncotarget 2017, 5: 36054-36066. PMID: 28415602, PMCID: PMC5482638, DOI: 10.18632/oncotarget.16425.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsApoptosisBreast NeoplasmsCell Line, TumorDrug Resistance, NeoplasmErbB ReceptorsFemaleGene Expression Regulation, NeoplasticHumansLapatinibMiceMice, Inbred BALB CMice, NudeMyeloid Cell Leukemia Sequence 1 ProteinNuclear ProteinsQuinazolinesReceptor, ErbB-2RNA, Small InterferingSignal TransductionSurvival AnalysisXenograft Model Antitumor AssaysConceptsErbB2-positive breast cancer cellsErbB2-positive breast cancerPathologic complete responseLapatinib responseBreast cancerBreast cancer cellsEstrogen receptorLapatinib resistanceBetter survivalERBB2 expressionDual tyrosine kinase inhibitorLapatinib-induced apoptosisCancer cellsERBB2-positive breast cancer cell linesBreast cancer cell linesTyrosine kinase inhibitorsJIMT-1 cellsMDA-MB-453Cell line BT-474SK-BR-3Cancer cell linesComplete responseER statusJIMT-1Xenograft tumors
2015
Maize reas1 Mutant Stimulates Ribosome Use Efficiency and Triggers Distinct Transcriptional and Translational Responses
Qi W, Zhu J, Wu Q, Wang Q, Li X, Yao D, Jin Y, Wang G, Wang G, Song R. Maize reas1 Mutant Stimulates Ribosome Use Efficiency and Triggers Distinct Transcriptional and Translational Responses. Plant Physiology 2015, 170: 971-988. PMID: 26645456, PMCID: PMC4734584, DOI: 10.1104/pp.15.01722.Peer-Reviewed Original ResearchMeSH KeywordsCell ProliferationCloning, MolecularConserved SequenceDown-RegulationGene Expression Regulation, PlantGene OntologyGenes, PlantModels, BiologicalMutationNucleosomesPhenotypePhylogenyProtein BiosynthesisRibosome Subunits, Large, EukaryoticRibosomesTranscription, GeneticUp-RegulationZea maysConceptsRibosome biogenesisCellular responsesWeak mutant alleleFundamental cellular processesDistinct cellular responsesEukaryotic initiation factor 2αRibosome exportSeed mutantRibosome maturationAAA-ATPaseRibosome processingCellular processesDNA replicationRibosome subunitsDistinct TranscriptionalTranslational efficiencyTranslational responseTranslational levelTranslation levelsGene expressionDevelopmental defectsInhibited cell growthMutant allelesBiogenesisReduced phosphorylation
2014
Characterization of the Promoter of a Homolog of Maize MADS-Box Gene m18
QIN H, Hong P, FAN X, Qiao W, LI Y. Characterization of the Promoter of a Homolog of Maize MADS-Box Gene m18. Journal Of Integrative Agriculture 2014, 13: 2330-2345. DOI: 10.1016/s2095-3119(13)60677-2.Peer-Reviewed Original ResearchMultiple abiotic stressesMultiple cis-acting elementsAbiotic stressesCis-acting elementsMajor food cropsDicot speciesHeterologous expressionMADS-box gene expressionMADS-box genesWorld's major food cropsCategories of genesTremendous yield lossesUnderstanding of regulationPlant responsesExpression regulationTATA boxGene expressionRegulated expressionWater deficitMaize responseVersatile rolesPromoterVersatile functionsYield lossFood cropsExistence of abiotic stress-responsive genes within the regions of QTLs controlling maize grain yield: One of the root causes for unstability of the QTLs?
Wu Q, Shu P, Cai T, Fan X, Li Y. Existence of abiotic stress-responsive genes within the regions of QTLs controlling maize grain yield: One of the root causes for unstability of the QTLs? South African Journal Of Botany 2014, 93: 231-241. DOI: 10.1016/j.sajb.2014.03.020.Peer-Reviewed Original ResearchAbiotic stress-responsive genesQuantitative trait lociStress-responsive genesStress-regulated genesGene componentsRegions of QTLsEnvironmental conditionsAbiotic stressesFunctional genesTrait lociGene expressionGenesConditional expressionInformative cluesGrain yieldMaize grain yieldMaizeExpressionChromosomesLociMaize yieldFurther utilizationRootsRegionYieldInterruption of KLF5 acetylation converts its function from tumor suppressor to tumor promoter in prostate cancer cells
Li X, Zhang B, Wu Q, Ci X, Zhao R, Zhang Z, Xia S, Su D, Chen J, Ma G, Fu L, Dong J. Interruption of KLF5 acetylation converts its function from tumor suppressor to tumor promoter in prostate cancer cells. International Journal Of Cancer 2014, 136: 536-546. PMID: 24931571, PMCID: PMC4232457, DOI: 10.1002/ijc.29028.Peer-Reviewed Original ResearchConceptsKLF5 acetylationTumor suppressingAcetylation-dependent mannerFunction of TGFβExpression of genesTumor suppressor activityCancer cellsNoncancerous epithelial cellsDU-145 prostate cancer cell linesTranscriptional complexRNA sequencingProstate cancer cell linesAcetylation statusExpression changesTumor suppressorProstate cancer cellsProtumorigenic functionsKLF5Cancer cell linesNovel insightsMYCAcetylationSuppressor activityCell linesNude mice
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