Qian Yu
Associate Research ScientistAbout
Research
Publications
2025
Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice
Yu Q, Tang X, Hart T, Homer R, Belperron A, Bockenstedt L, Ring A, Nakamura A, Fikrig E. Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice. ELife 2025, 14: rp104913. PMID: 40392222, PMCID: PMC12092001, DOI: 10.7554/elife.104913.Peer-Reviewed Original ResearchConceptsSecretory leukocyte protease inhibitorJoint inflammationC57BL/6 miceHigher infection loadTick-borne infectionsWild-type control miceClinical manifestations of infectionDevelopment of Lyme arthritisElevated serum levelsExcessive pro-inflammatory responsesManifestations of infectionProtease inhibitorsPro-inflammatory responseAnkle joint tissueInfection loadPromote tissue repairAnti-inflammatory effectsSerum levelsPeriarticular swellingClinical manifestationsControl miceTibiotarsal jointMMP-8Lyme diseaseIL-6Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice
Yu Q, Tang X, Hart T, Homer R, Belperron A, Bockenstedt L, Ring A, Nakamura A, Fikrig E. Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice. ELife 2025, 14 DOI: 10.7554/elife.104913.4.Peer-Reviewed Original ResearchSecretory leukocyte protease inhibitorSLPI-deficient miceJoint inflammationC57BL/6 miceDeficient miceB. burgdorferiHigher infection loadTick-borne infectionsWild-type control miceDeficient C57BL/6 miceClinical manifestations of infectionDevelopment of Lyme arthritisElevated serum levelsExcessive pro-inflammatory responsesManifestations of infectionProtease inhibitorsPro-inflammatory responseAnkle joint tissueInfection loadPromote tissue repairAnti-inflammatory effectsSerum levelsPeriarticular swellingClinical manifestationsControl miceCCL17 Influences Borrelia burgdorferi Infection in the Heart
Tang X, Yu Q, Cui Y, Hart T, Rivas-Giorgi F, Calloway K, Mohapatra A, Fikrig E. CCL17 Influences Borrelia burgdorferi Infection in the Heart. Journal Of Infectious Diseases 2025, 232: 162-169. PMID: 39777514, PMCID: PMC12308671, DOI: 10.1093/infdis/jiaf011.Peer-Reviewed Original ResearchSerum levels of proinflammatory cytokinesLevels of proinflammatory cytokinesVector-Borne PathogensB. burgdorferiReduce pathogen loadImmune alterationsMacrophage infiltrationProinflammatory cytokinesCCL17B. burgdorferi infectionIxodes ticksPathogen loadControl animalsChemokinesBorrelia burgdorferiInfectious diseasesInfectionDiverse illnessesKnockoutLyme diseaseDisease
2024
Neisseria gonorrhoeae induces local secretion of IL-10 at the human cervix to promote colonization
Dai Y, Edwards V, Yu Q, Tettelin H, Stein D, Song W. Neisseria gonorrhoeae induces local secretion of IL-10 at the human cervix to promote colonization. Journal Of Clinical Investigation 2024, 135: e183331. PMID: 39585777, PMCID: PMC11735093, DOI: 10.1172/jci183331.Peer-Reviewed Original Research
2023
The mucosal immune responses of the human cervix are modulated by Neisseria gonorrhoeae
Song W, Dai Y, Yu Q, Edwards V, Tettelin H, Stein D. The mucosal immune responses of the human cervix are modulated by Neisseria gonorrhoeae. The Journal Of Immunology 2023, 210: 69.08-69.08. DOI: 10.4049/jimmunol.210.supp.69.08.Peer-Reviewed Original Research
2021
Gonococcal invasion into epithelial cells depends on both cell polarity and ezrin
Yu Q, Wang L, Di Benigno S, Stein D, Song W. Gonococcal invasion into epithelial cells depends on both cell polarity and ezrin. PLOS Pathogens 2021, 17: e1009592. PMID: 34852011, PMCID: PMC8668114, DOI: 10.1371/journal.ppat.1009592.Peer-Reviewed Original Research
2020
Adaptation of Neisseria gonorrhoeae to the Female Reproductive Tract
Song W, Yu Q, Wang L, Stein D. Adaptation of Neisseria gonorrhoeae to the Female Reproductive Tract. Microbiology Insights 2020, 13: 1178636120947077. PMID: 32848409, PMCID: PMC7425258, DOI: 10.1177/1178636120947077.Peer-Reviewed Original Research
2019
Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms
Yu Q, Wang L, Di Benigno S, Gray-Owen S, Stein D, Song W. Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms. PLOS Pathogens 2019, 15: e1008136. PMID: 31790511, PMCID: PMC6907876, DOI: 10.1371/journal.ppat.1008136.Peer-Reviewed Original Research
2018
Immunofluorescence Analysis of Human Endocervical Tissue Explants Infected with Neisseria gonorrhoeae.
Wang L, Yu Q, Stein D, Song W. Immunofluorescence Analysis of Human Endocervical Tissue Explants Infected with Neisseria gonorrhoeae. Bio-protocol 2018, 8 PMID: 29780854, PMCID: PMC5959038, DOI: 10.21769/bioprotoc.2720.Peer-Reviewed Original Research
2017
Neisseria gonorrhoeae infects the human endocervix by activating non-muscle myosin II-mediated epithelial exfoliation
Wang L, Yu Q, Edwards V, Lin B, Qiu J, Turner J, Stein D, Song W. Neisseria gonorrhoeae infects the human endocervix by activating non-muscle myosin II-mediated epithelial exfoliation. PLOS Pathogens 2017, 13: e1006269. PMID: 28406994, PMCID: PMC5391109, DOI: 10.1371/journal.ppat.1006269.Peer-Reviewed Original Research
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