Poojith Nuthalapati
Associate Research ScientistAbout
Research
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Featured Publications
Examining psychiatric and cognitive adverse effects of brivaracetam, clobazam, lacosamide, eslicarbazepine, and perampanel in a veteran population
Nuthalapati P, DeBonis D, Gopaul M, Okafor C, Orner M, Jimenez A, Altalib H. Examining psychiatric and cognitive adverse effects of brivaracetam, clobazam, lacosamide, eslicarbazepine, and perampanel in a veteran population. Epilepsy & Behavior 2025, 172: 110557. PMID: 40570732, DOI: 10.1016/j.yebeh.2025.110557.Peer-Reviewed Original ResearchVeteran populationRetrospective analysis of veteransPopulation of veteransAnalysis of veteransICD-10 codesPsychiatric adverse effectsAnti-seizure medicinesVA systemICD-10Neurology noteMale participantsVeteransCognitive adverse effectsSafety analyticsIntegrated programCognitive disordersAdverse effectsORQ1-Q3Treatment initiationChronic neurological disorderExercise cautionEffects of brivaracetamPopulationMedian ageInterventional Brain Medicine: Medicine's newest frontier
Nuthalapati P, Palmer C, Barbosa D, George M, Brown J. Interventional Brain Medicine: Medicine's newest frontier. Brain Medicine 2024, 1: 3-5. DOI: 10.61373/bm024g.0013.Commentaries, Editorials and LettersImproving Seizure Frequency Documentation and Classification
Nuthalapati P, Thomas L, Donahue M, Moura L, DeStefano S, Simpson J, Buchhalter J, Fureman B, Pellinen J. Improving Seizure Frequency Documentation and Classification. Neurology Clinical Practice 2023, 13: e200212. PMID: 37873534, PMCID: PMC10586801, DOI: 10.1212/cpj.0000000000200212.Peer-Reviewed Original ResearchElectronic health recordsEpilepsy Learning Healthcare SystemClinic visitsLearning healthcare systemQuality of careBaseline dataQuality improvement projectBaseline data collectionEpilepsy clinicHealth recordsCase report formsDocumentation habitsImprovement projectHealthcare systemDocumentation toolsReport formsVisitsEvaluate treatment strategiesClinicData collectionSeizure documentationBaselineSeizure frequencyCritical metricsCareAn analysis of structural, spectroscopic, quantum chemical and in silico studies of ethyl 3-[(pyridin-2-yl)amino]propanoate: A potential thrombin inhibitor
Poojith N, Rani N, Potla K, Rose J, Suchetan P, Pillai R, Vankayalapati S. An analysis of structural, spectroscopic, quantum chemical and in silico studies of ethyl 3-[(pyridin-2-yl)amino]propanoate: A potential thrombin inhibitor. Journal Of Molecular Structure 2021, 1226: 129378. DOI: 10.1016/j.molstruc.2020.129378.Peer-Reviewed Original ResearchBond dissociation energiesTitle compoundDissociation energiesSingle-crystal X-ray diffraction techniquesCrystal structureHydrogen-bond dissociation energiesNatural bond orbital analysisMolecular electrostatic surface potentialIn silico studiesOrbital energy calculationsPotential thrombin inhibitorsBond orbital analysisChemical reactivity descriptorsElectron density surfaceQuantum chemical calculationsVibrational wave numbersX-ray diffraction techniqueMolecular docking studiesExperimental spectral dataC-H.Fukui functionsReactivity descriptorsChemical calculationsQuantum chemicalOrbital analysisStructural, spectroscopic, and in silico studies of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol: A potential antidepressant agent
Poojith N, Kigga M, Rose J, Potla K, Vankayalapati S, Chinnam S, Adimoole S, Pillai R. Structural, spectroscopic, and in silico studies of 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol: A potential antidepressant agent. Journal Of Molecular Structure 2022, 1250: 131859. DOI: 10.1016/j.molstruc.2021.131859.Peer-Reviewed Original ResearchMolecular electrostatic potentialPotential energy distributionDissociation energiesReactivity parametersCrystal X-ray diffractionSide chainsOrthorhombic P212121 space groupIn silico studiesLocal reactivity propertiesGlobal reactivity parametersN hydrogen bondsC(6) chainsMolecular orbital analysisP212121 space groupX-ray diffractionEnergy of hydrogenTitle compoundVibrational wavenumbersFukui functionsStaggered conformationThiophene ringCompound crystallizesOrbital analysisDihedral angleMethine carbon
2026
Predictors of Emergency Care Utilization in Veterans with Psychogenic Nonepileptic Seizures (PNES) (P1-11.004)
Hossameldin S, Nuthalapati P, Gopaul M, Altalib H. Predictors of Emergency Care Utilization in Veterans with Psychogenic Nonepileptic Seizures (PNES) (P1-11.004). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000217602.Peer-Reviewed Original ResearchGlymphatic system dysfunction in epilepsy: a systematic review and meta-analysis
Raj R, Sharma A, Singhal A, Kansal B, Agarwal A, Bathla G, Nuthalapati P, Duggal A, Ali M. Glymphatic system dysfunction in epilepsy: a systematic review and meta-analysis. Epilepsy & Behavior 2026, 183: 111141. PMID: 42250499, DOI: 10.1016/j.yebeh.2026.111141.Peer-Reviewed Original ResearchDTI-ALPSMeta-analysisPooled mean differenceNewcastle-Ottawa Scale toolDTI-ALPS indexSystematic reviewRandom-effects modelPrimary meta-analysisTrim-and-fill analysisHuman observational studiesMulticenter studyGlymphatic system dysfunctionClinical correlatesSubgroup analysisDisease durationHealthy controlsPROSPERO registrationWeb of ScienceDisease chronicityEpilepsy onsetSystem dysfunctionEpilepsy syndromesObservational studyTrim-and-fillMean differenceBurden of headache among people with epilepsy: A systematic review and meta-analysis
Sharma A, Paruchuri A, Kola P, P N, Pal A, Agarwal H, Tiwari H, Nuthalapati P, Beriwal N, Kansal B, Garg R, Malhotra H, Singh A, Singh M, Suresh V. Burden of headache among people with epilepsy: A systematic review and meta-analysis. Seizure 2026, 138: 71-83. PMID: 41990684, DOI: 10.1016/j.seizure.2026.02.015.Peer-Reviewed Original ResearchBurden of headacheRandom-effects meta-analysesHeadache prevalencePooled prevalence of headachePooled prevalencePublication biasSystematic reviewRandom-effects meta-analyses of proportionsMeta-analysisPrevalence of headacheMeta-analyses of proportionsWeb of ScienceLFK indexEpilepsy careBackground HeadachePrevalence estimatesHeadache assessmentInterictal headacheHeadache subtypesFrequent subtypePostictal headachesSubgroup analysisUnderrecognized burdenCortical hyperexcitabilityObservational studyCenobamate beyond Epilepsy: exploring associations with vascular risk factors through serological markers
Jimenez A, Zhou X, Agadzhanian N, Hanin A, Toghramadjian I, Okafor C, Nuthalapati P, Tallapalli J, Sakya S, Singh A, Altalib H, Mattson R, Schoenfeld M, Herlopian A. Cenobamate beyond Epilepsy: exploring associations with vascular risk factors through serological markers. Epilepsy & Behavior 2026, 176: 110890. PMID: 41616663, DOI: 10.1016/j.yebeh.2026.110890.Peer-Reviewed Original ResearchInternational normalized ratioAnti-seizure medicationsTotal cholesterolLDL-CHDL-CRetrospective analysisLipoprotein cholesterolVascular effectsDiabetes mellitusRisk factorsLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolRetrospective analysis of adultsDefinitive evaluationLipid profile changesEnzyme-inducing agentsDose-dependent changesDose-dependent effectCerebrovascular risk factorsAnalysis of adultsStatin useAnticoagulant useMulticenter studyRetrospective studyVascular risk factorsStudy protocol for a prospective, cluster randomised control, hybrid type 1 effectiveness-implementation trial to evaluate the Reduction Of Seizures through Education and Support: the ROSES study
Altalib H, Nuthalapati P, Ali S, Gopaul M, Okafor C, Gaglio B, Herbst A, Dewain S, Hossameldin S, Speranza F, Deep P, Fischbein K, Hirsch L, Pugh M, Clary H. Study protocol for a prospective, cluster randomised control, hybrid type 1 effectiveness-implementation trial to evaluate the Reduction Of Seizures through Education and Support: the ROSES study. BMJ Neurology Open 2026, 8: e001467. PMID: 42367638, PMCID: PMC13295823, DOI: 10.1136/bmjno-2025-001467.Peer-Reviewed Original ResearchAcute seizure action plansSeizure action planClinical templatesAction planEffectiveness-implementation studyEffectiveness-implementation trialTheoretical Domains FrameworkQuality measure scoresGeneral health educationMixed-methods designIndividual quality measuresPeer-reviewed publicationsMedication side effectsCare qualityHealthcare utilisationHealthcare useProvider interviewsDomains FrameworkBaseline interviewHealth educationPatient educationMeasure scoresNeurology visitsUS populationConference presentations
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